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  • 1
    Call number: QZ208:158
    Keywords: Neoplasms / genetics ; Genomics ; Precision Medicine ; Biomarkers, Tumor
    Pages: xxii, 698 pages : illustrations
    ISBN: 9780128117859
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  • 2
    Keywords: Medicine ; Immunology ; Neurosciences ; Pharmacology ; Virology ; Biomedicine ; Immunology ; Neurosciences ; Pharmacology/Toxicology ; Virology ; Springer eBooks
    Description / Table of Contents: Preface -- Introductory remarks -- Giant Cell Arteritis -- Takayasu Arteritis -- Polyarteritis Nodosa -- Mechanisms of ANCA-Associated Vasculitides -- Granulomatosis with Polyangiitis (Wegeneŕ€™s) and Similar €œÁAV with Probable Etiologý€ -- Eosinophilic Granulomatosis with Polyangiitis (Churg Strauss) -- Anti-Glomerular Basement Membrane Disease -- IgA Vasculitis -- HCV-Related Cryoglobulinemic Vasculitis -- Vasculitis and Pulmonary Hypertension: New Therapeutic Approaches -- Vasculitis in SLE, RA and Other Connective Tissue Diseases: Diagnosis and Treatment -- Central Nervous System Vasculitis -- Uveitis -- IgG4 Syndrome -- Beh©ʹet Syndrome -- Urticarioid Vasculitis -- Guidelines for the Diagnosis and Treatment of Vasculitides -- Index
    Abstract: The systemic vasculitides,includinglarge, medium, small, and variable vessel vasculitis,have been the focus of intensive basic and clinical investigations over the last twodecades. Among theimportant advances stemming from these efforts are new definitions, classifications, and diagnostic criteria for the different classes of vasculitis; the addition of anti-neutrophil cytoplasmic autoantibodies as a new criterion for classifying vasculitis; the recognition of the viral etiology of conditions such as cryoglobulinemic vasculitis and polyarteritis nodosa; an appreciation of thebroad spectrum of clinical manifestations and potentially devastating complicationsassociated with vasculitis; the many features and remarkable clinical heterogeneity of IgG4-related, immune-mediated diseases; and the proposal of intriguing pathogenetic hypotheses for certain chronic, relapsing vasculitides. This improved understanding of the systemic vasculitides has been accompanied by a trend away from the use of eponyms for these conditions; thus, established terms such as Wegeneŕ€™s granulomatosis and Churg-Strauss syndrome have been replacedby the more descriptive definitions ́€œgranulomatosis with polyangiitiś€ and €œéosinophilic granulomatosis with polyangiitis,́€ respectively. Additional clinical laboratory tests,rapidly developing imaging techniques that can assess inflammation, especially in large-vessel vasculitis, and artificial neural network approaches will no doubt bring a wealth of informationthat ultimately leads to the identification of novel disease biomarkers. Expected applications include the identification of individuals at increased risk ofrelapsewho would benefit from patient-tailored therapy. Although the conventional combination of glucocorticoids and immunosuppressive drugs is effective in the treatment of a large proportion of vasculitic disorders, safer medications, with fewer side effects, are being developed, includingseveral biological agents now being closely evaluated in multi-center studies. This volume brings togethercomprehensive and up-to-date reviews written by experiencedscientists and clinicians from many countries. Its aim is toprovide readers with state-of-the-art knowledge of the major vasculitides and cutting-edge insights into their multi-faceted features. It is our hope that this book serves as a valuable and stimulating resourcefor basic and clinical researchers, specialists in related disciplines, as well as practicing physicians and advanced medical students interested in this fascinating branch of pathology. Franco Dammacco, Domenico Ribatti, Angelo Vacca
    Pages: XI, 438 p. 78 illus., 55 illus. in color. : online resource.
    ISBN: 9783319401362
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  • 3
    Keywords: Medicine ; Internal Medicine ; Clinical Medicine ; Emerging infectious diseases ; Oncology ; Rheumatology ; Medicine & Public Health ; Hepatology ; Internal Medicine ; Infectious Diseases ; Rheumatology ; Oncology ; Springer eBooks
    Pages: : digital
    ISBN: 9788847017054
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  • 4
    ISSN: 1573-2592
    Keywords: HIV infection ; CD4 receptor ; anti-T-cell antibodies ; T-helper defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Isotype and binding characteristics of T cell-reactive antilymphocyte antibodies (ALA) were investigated in 287 human immunodeficiency virus (HIV)+ sera from patients with CDC II to IVC clinical disease. Using purified soluble T-lymphoblast (CEM cell line) membranes and an ELISA method, 29 HIV+ sera showed significant reactions with this substrate and a selective expression of IgG-ALA was detected in 7 HIV+ sera. Subsequent microcytotoxicity assays, utilizing peripheral T lymphocytes and CEM cells as targets, demonstrated no significant cytotoxic capability in such sera, whereas 12 of 17 HIV+ serum samples with IgM-ALA ELISA reactivities showed a significant degree of killing in the Terasaki test. Further experiments of saturation of CD4 molecules on CEM extract by OKT4 monoclonal antibody (MoAb) induced a high inhibition of IgG-ALA binding to the T-cell membranes in only two IgG-ALA+ sera (No. 93, CDC III; No. 179, CDC II stage). Conversely, treatment of CEM membrane lysate with Leu3a MoAb, specific for the gp120 reactive domain of the HIV receptor, failed to prevent membrane binding in all seven of the IgG-ALA+ sera. Following the adsorption of serum 93 on a T-cell membrane antigen affinity column, SDS-PAGE analysis demonstrated that the predominant ALA material reacting with T-cell membranes was IgG with no detectable traces of IgM. These data provide evidence that ALA in HIV+ patients may be simultaneously or selectively expressed as IgG and/or IgM with different properties. While IgM-ALA show predominant cytotoxic activity, IgG-ALA may include anti-CD4 molecules. However, IgG binding to the C-terminal domain of native HIV receptor appears to occur at a lower rate than IgM-ALA in HIV infection.
    Type of Medium: Electronic Resource
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