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  • 1
    Online Resource
    Online Resource
    Milano : : Springer,
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: digital
    ISBN: 9788847017054
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham : : Springer International Publishing, | Cham : : Springer International Publishing :
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: XI, 438 p. 78 illus., 55 illus. in color. , online resource.
    ISBN: 9783319401362
    Language: English
    Note: Preface -- Introductory remarks -- Giant Cell Arteritis -- Takayasu Arteritis -- Polyarteritis Nodosa -- Mechanisms of ANCA-Associated Vasculitides -- Granulomatosis with Polyangiitis (Wegener���s) and Similar ���AAV with Probable Etiology��� -- Eosinophilic Granulomatosis with Polyangiitis (Churg Strauss) -- Anti-Glomerular Basement Membrane Disease -- IgA Vasculitis -- HCV-Related Cryoglobulinemic Vasculitis -- Vasculitis and Pulmonary Hypertension: New Therapeutic Approaches -- Vasculitis in SLE, RA and Other Connective Tissue Diseases: Diagnosis and Treatment -- Central Nervous System Vasculitis -- Uveitis -- IgG4 Syndrome -- Beh��et Syndrome -- Urticarioid Vasculitis -- Guidelines for the Diagnosis and Treatment of Vasculitides -- Index.
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  • 3
    Book
    Book
    London : : Elsevier, | London : : Elsevier/Academic Press,
    Call number: QZ208:158
    Type of Medium: Book
    Pages: xxii, 698 pages : , illustrations
    ISBN: 9780128117859 , 0128117850
    Language: English
    Location: DKFZ
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  • 4
    ISSN: 1573-2592
    Keywords: HIV infection ; CD4 receptor ; anti-T-cell antibodies ; T-helper defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Isotype and binding characteristics of T cell-reactive antilymphocyte antibodies (ALA) were investigated in 287 human immunodeficiency virus (HIV)+ sera from patients with CDC II to IVC clinical disease. Using purified soluble T-lymphoblast (CEM cell line) membranes and an ELISA method, 29 HIV+ sera showed significant reactions with this substrate and a selective expression of IgG-ALA was detected in 7 HIV+ sera. Subsequent microcytotoxicity assays, utilizing peripheral T lymphocytes and CEM cells as targets, demonstrated no significant cytotoxic capability in such sera, whereas 12 of 17 HIV+ serum samples with IgM-ALA ELISA reactivities showed a significant degree of killing in the Terasaki test. Further experiments of saturation of CD4 molecules on CEM extract by OKT4 monoclonal antibody (MoAb) induced a high inhibition of IgG-ALA binding to the T-cell membranes in only two IgG-ALA+ sera (No. 93, CDC III; No. 179, CDC II stage). Conversely, treatment of CEM membrane lysate with Leu3a MoAb, specific for the gp120 reactive domain of the HIV receptor, failed to prevent membrane binding in all seven of the IgG-ALA+ sera. Following the adsorption of serum 93 on a T-cell membrane antigen affinity column, SDS-PAGE analysis demonstrated that the predominant ALA material reacting with T-cell membranes was IgG with no detectable traces of IgM. These data provide evidence that ALA in HIV+ patients may be simultaneously or selectively expressed as IgG and/or IgM with different properties. While IgM-ALA show predominant cytotoxic activity, IgG-ALA may include anti-CD4 molecules. However, IgG binding to the C-terminal domain of native HIV receptor appears to occur at a lower rate than IgM-ALA in HIV infection.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2020-10-07
    Description: Takayasu arteritis (TAK) is a rare granulomatous vasculitis of unknown etiology that mainly affects the aorta and its major branches. The aim is to describe the clinical features, diagnostic procedures, pathogenesis, and management of TAK in a longitudinal cohort of patients recruited within a single region of southern Italy. The cohort included 43 patients who were diagnosed with TAK and followed up according to a standard protocol, in a collaboration between four university tertiary referral centers and a regional hospital. Clinical and imaging classification criteria were those established by the American College of Rheumatology. Thirty-five patients (81.4%) were female, and the mean age at disease onset was 32.6 (range 16–54) years. Angiographic assessment of the vascular involvement allowed disease classification in five different types. Clinical features ranged from constitutional symptoms in the early inflammatory stage of the disease to cardiovascular ischemic symptoms in the late, chronic stage. Noninvasive imaging techniques were employed to assess the extent and severity of the arterial wall damage and to monitor the clinical course and response to therapy. Medical treatment, based on pathogenetic insights into the roles of humoral and cell-mediated immune mechanisms, included glucocorticoids mostly combined with steroid-sparing immunosuppressive agents and, in patients with relapsing/refractory disease, biologic drugs. Significant clinical and angiographic differences have been detected in TAK patients from different geographic areas. Patients with life-threatening cardiovascular and neurologic manifestations as well as sight-threatening ophthalmologic signs and symptoms should be promptly diagnosed, properly treated, and closely followed up to avoid potentially severe consequences.
    Print ISSN: 1591-8890
    Electronic ISSN: 1591-9528
    Topics: Medicine
    Published by Springer
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