Syndrome of inappropriate antidiuretic hormone
Springer Online Journal Archives 1860-2000
Abstract We conducted a retrospective analysis of the cases of 122 children operated on for various brain tumors, to determine the incidence and natural history of post-operative diabetes insipidus (DI), and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Abnormalities of water homeostasis were observed in 15 patients (12%). DI, with or without SIADH, was observed in 10 patients (8%), while SIADH alone was seen in five (4%). DI was permanent in five subjects (50%), whereas SIADH resolved completely in all affected individuals. Parenteral desmopressin (dDAVP) was an effective mode of therapy in the postoperative period. The effect did not correlate with a dosage strictly based on body weight.
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