Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: CANCER ; CELLS ; Germany ; SYSTEM ; DISEASES ; HISTORY ; RISK ; ASSOCIATION ; LYMPHOMA ; MALIGNANCIES ; NUMBER ; AGE ; CHILDREN ; non-hodgkin's lymphoma ; Hodgkin's lymphoma ; FOLLICULAR LYMPHOMA ; NON-HODGKINS-LYMPHOMA ; multiple myeloma ; MALIGNANCY ; ADULT ; ADULTS ; case-control study ; CHILDHOOD ; HYGIENE HYPOTHESIS ; SAN-FRANCISCO ; RE ; RHEUMATOID-ARTHRITIS ; allergy ; B-CLL ; case control studies ; diffuse large B-cell lymphoma ; ACUTE-LEUKEMIA ; B-NHL ; LYMPHOMAS ; MALT lymphoma ; T-NHL ; urticaria
    Abstract: Since lymphomas are malignancies of cells of the immune system, associations with disorders characterised by impaired immune functions can be assumed. We investigated the relationship between a history of selected medical conditions and the risk for lymphoma including specified subentities within our population-based case-control study of lymphoma among adults conducted in Germany between 1999 and 2002. Overall, we found decreased risks for a history of repeated diarrhoea, warts, arthrosis, allergies, and appendectomy (at a younger age). Elevated risks for lymphoma correlated with tonsillectomy (at a younger age), whereas null results were found for selected auto-immune disorders in adulthood. Although the numbers are small, most of the results for the subentities corresponded with these findings. These results are compatible with the notion that persistent immunological alterations contribute to the aetiology of lymphoma, but partially inconsistent with the Th1/Th2-shift paradigm. (C) 2004 Elsevier Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 15617998
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: Germany ; occupation ; POPULATION ; RISK-FACTORS ; LYMPHOMA ; UNITED-STATES ; ASBESTOS EXPOSURE ; MULTIPLE-MYELOMA ; NON-HODGKINS-LYMPHOMA ; case control studies ; ELECTRIC UTILITY WORKERS ; MULTICENTER CASE-CONTROL ; MAGNETIC-FIELDS ; ORGANIC-SOLVENTS ; DEATH-CERTIFICATE
    Type of Publication: Journal article published
    PubMed ID: 16361401
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: Germany ; DIAGNOSIS ; SUPPORT ; EXPOSURE ; HISTORY ; POPULATION ; RISK ; PATIENT ; ASSOCIATION ; CARBON ; LYMPHOMA ; HEALTH ; AGE ; smoking ; REGION ; REGIONS ; SAFETY ; case-control studies ; ALCOHOL ; ALCOHOL-CONSUMPTION ; CONSUMPTION ; FOLLICULAR LYMPHOMA ; AROMATIC-HYDROCARBONS ; case control study ; case-control study ; REGRESSION ; INCREASE ; case control studies ; INTERVAL ; analysis ; methods ; POWER ; female ; Male ; odds ratio ; population-based ; E ; case control ; LOGISTIC-REGRESSION ; POINT ; case-control ; CLICK ; PERSONAL INTERVIEW
    Abstract: To analyze the relationship between exposure to chlorinated and aromatic organic solvents and malignant lymphoma in a multi-centre, population-based case-control study. METHODS: Male and female patients with malignant lymphoma (n = 710) between 18 and 80 years of age were prospectively recruited in six study regions in Germany (Ludwigshafen/Upper Palatinate, Heidelberg/Rhine-Neckar-County, Würzburg/Lower Frankonia, Hamburg, Bielefeld/Gütersloh, and Munich). For each newly recruited lymphoma case, a gender, region and age-matched (+/- 1 year of birth) population control was drawn from the population registers. In a structured personal interview, we elicited a complete occupational history, including every occupational period that lasted at least one year. On the basis of job task-specific supplementary questionnaires, a trained occupational physician assessed the exposure to chlorinated hydrocarbons (trichloroethylene, tetrachloroethylene, dichloromethane, carbon tetrachloride) and aromatic hydrocarbons (benzene, toluene, xylene, styrene). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression analysis, adjusted for smoking (in pack years) and alcohol consumption. To increase the statistical power, patients with specific lymphoma subentities were additionally compared with the entire control group using unconditional logistic regression analysis. RESULTS: We observed a statistically significant association between high exposure to chlorinated hydrocarbons and malignant lymphoma (Odds ratio = 2.1; 95% confidence interval 1.1-4.3). In the analysis of lymphoma subentities, a pronounced risk elevation was found for follicular lymphoma and marginal zone lymphoma. When specific substances were considered, the association between trichloroethylene and malignant lymphoma was of borderline statistical significance. Aromatic hydrocarbons were not significantly associated with the lymphoma diagnosis. CONCLUSION: In accordance with the literature, this data point to a potential etiologic role of chlorinated hydrocarbons (particularly trichloroethylene) and malignant lymphoma. Chlorinated hydrocarbons might affect specific lymphoma subentities differentially. Our study does not support a strong association between aromatic hydrocarbons (benzene, toluene, xylene, or styrene) and the diagnosis of a malignant lymphoma.
    Type of Publication: Journal article published
    PubMed ID: 17407545
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: Germany ; COHORT ; EPIDEMIOLOGY ; RISK ; LYMPHOMA ; CIGARETTE-SMOKING ; MEN ; smoking ; case-control studies ; TOBACCO ; ALCOHOL ; ALCOHOL-CONSUMPTION ; CONSUMPTION ; LIFE-STYLE ; MULTIPLE-MYELOMA ; OLDER WOMEN ; NON-HODGKINS-LYMPHOMA ; case-control study ; population-based case-control study ; RE ; case control studies ; alcohol consumption ; HEMATOLYMPHOPOIETIC MALIGNANCIES ; NICOTINE ; WOMEN UNITED-STATES
    Type of Publication: Journal article published
    PubMed ID: 16080191
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: RECEPTOR ; Germany ; SYSTEM ; EPIDEMIOLOGY ; RISK ; GENE ; GENES ; TISSUE ; DNA ; DENDRITIC CELLS ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; single nucleotide polymorphism ; SUSCEPTIBILITY ; ALPHA ; LYMPHOMA ; genetics ; SNP ; IMMUNE-RESPONSE ; RECEPTORS ; HELICOBACTER-PYLORI ; heredity ; TOLL-LIKE RECEPTORS ; Hodgkin's lymphoma ; CROHNS-DISEASE ; FOLLICULAR LYMPHOMA ; TNF-ALPHA ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; CYTOKINE ; MEDICAL HISTORY ; VARIANT ; SINGLE NUCLEOTIDE POLYMORPHISMS ; PATTERN-RECOGNITION ; IMMUNE-SYSTEM ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; REGULATORY T-CELLS ; INTERVAL ; SUBTYPES ; single-nucleotide ; single-nucleotide polymorphism ; LYMPHOMAS ; INCREASED RISK ; odds ratio ; population-based ; chronic lymphocytic leukaemia ; FUNCTIONAL POLYMORPHISM ; IL-10 ; INTERLEUKIN-10 ; NON-HODGKIN-LYMPHOMA ; IL10 ; IL10RA ; STOP CODON POLYMORPHISM ; TLR
    Abstract: Interactions between environment and immune system play an essential role in the aetiology of immunopathologies, including lymphomas. Toll-like receptors (TLR) belong to a group of pattern recognition receptors, with importance for innate immune response and inflammatory processes. Interleukin-10 (IL-10) is a key regulatory cytokine and has been implicated in lymphomagenesis. Functional polymorphisms in these inflammation-associated genes may affect the susceptibility towards lymphoma. To test this hypothesis, we have genotyped DNA of 710 lymphoma cases and 710 controls within the context of a population-based epidemiological study for 11 functionally important single-nucleotide polymorphisms in TLR1, -2, -4, -5, -9, IL10 and IL10 receptor (IL10RA). The IL10RA Ser138Gly variant was underrepresented among lymphoma cases (odds ratio (OR) = 0.81, 95 per cent confidence interval (95% Cl) = 0.65-1.02), mainly owing to an inverse association with Hodgkin's lymphoma (HL). The TLR2 - 16933T 〉 A variant was associated with a 2.8-fold increased risk of follicular lymphoma (95% Cl = 1.43-5.59) and a decreased risk of chronic lymphocytic leukaemia (OR = 0.61, 95% Cl = 0.38-0.95). Furthermore, the TLR4 Asp299Gly variant was positively associated with the risk of mucosa-associated lymphoid tissue lymphoma (OR = 2.76, 95% Cl = 1.12-6.81) and HL (OR 1.80, 95% Cl = 0.99-3.26). In conclusion, this study suggests an effect of polymorphisms in factors of the innate immune response in the aetiology of some lymphoma subtypes
    Type of Publication: Journal article published
    PubMed ID: 16971956
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    Keywords: BLOOD ; Germany ; CLASSIFICATION ; DIAGNOSIS ; INFORMATION ; DISEASE ; DISEASES ; EPIDEMIOLOGY ; EXPOSURE ; HISTORY ; occupation ; POPULATION ; RISK ; SAMPLE ; INFECTION ; animals ; LYMPHOMA ; DESIGN ; AGE ; etiology ; leukemia ; UNITED-STATES ; case-control studies ; vaccination ; NON-HODGKINS-LYMPHOMA ; RABBIT ; IMMUNIZATION ; ADULT ; ADULTS ; case control study ; case-control study ; CHILDHOOD ; DIETARY FACTORS ; HAY-FEVER ; HL ; HUMAN T-CELLS ; HYGIENE HYPOTHESIS ; MEDICAL HISTORY ; NHL ; population-based case-control study ; REGISTRY ; REGRESSION ; SAN-FRANCISCO ; SHEEP
    Abstract: A multi-centre, population-based case-control study of lymphoma among adults was conducted in Germany from 1999-2003. The study comprised 700 incident cases (Hodgkin lymphomas and non Hodgkin's lymphoma, NHL) in the age range 18-80 years and 700 age-, sex- and area-matched controls obtained from population registries. Diagnosis was based on the REAL/WHO classification. Information on demographic characteristics, lifestyle, medical history and occupation was obtained by in-person interviews. Each participant was asked for a 24 ml blood sample. First results are focused on basic demographic characteristics, contact to animals, childhood diseases and vaccinations. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. The ORs for lymphoma were decreased for exposure to sheep and goats (OR = 0.7; 95% CI = 0.5-0.9), for rabbits and hare (OR = 0.7; 95% CI = 0.5-0.9), measles infection (OR = 0.6; 95% CI = 0.5-0.9), Bordetella pertussis infection (OR = 0.7; 95% CI = 0.6-0.95), and tetanus vaccination (OR = 0.5; 95% CI = 0.3-0.9). Increased risk of lymphoma was associated with exposure to cattle (OR = 1.3; 95% CI = 1.03-1.7) and immunization for tuberculosis (OR = 1.5; 95% CI = 0.997-2.4). The results of this study are partly consistent with the hygiene hypothesis. The inconsistencies of some of the findings with an explanation by the Th1/Th2 paradigm, however, warrant further research and may indicate that broader explanatory concepts are needed. (C) 2004 Elsevier Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 15158093
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Keywords: CANCER ; Germany ; EXPOSURE ; HISTORY ; MORTALITY ; POPULATION ; RISK ; WORKERS ; ASSOCIATION ; LYMPHOMA ; HEALTH ; NUMBER ; AGE ; SWEDEN ; REGION ; ASBESTOS ; INTERVIEW ; MULTIPLE-MYELOMA ; NON-HODGKINS-LYMPHOMA ; case-control study ; REGRESSION ; SCALE ; occupational exposures ; AREA ; REGISTER ; Malignant lymphoma
    Abstract: To analyze the relationship between asbestos exposure and malignant lymphoma in a multicenter case-control study conducted in Germany and Italy according to a common core protocol. Male and female patients with malignant lymphoma (n = 1,034) between 18 and 80 years of age were prospectively recruited in six study areas in Germany (Ludwigshafen/Upper Palatinate, Heidelberg/Rhine-Neckar-County, Wurzburg/Lower Frankonia, Hamburg, Bielefeld/East Westphalia, and Munich) and in two study areas in Sardinia, Italy (Cagliari and Nuoro provinces). A total of 1,173 population control subjects were drawn from population registers. In a structured personal interview, we elicited a complete occupational history, including every occupational period that lasted at least 1 year. On the basis of job task-specific supplementary questionnaires, trained experts assessed the exposure to asbestos. As a measure of cumulative asbestos exposure on a time by intensity scale, fiber-years were calculated. 12 cases (1.2%) and 12 control subjects (1.0%) had a cumulative asbestos exposure of more than 2.6 fiber-years (highest exposure category according to the 90th percentile of exposed control subjects). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression analysis adjusted for age, sex and study region. Patients with specific lymphoma sub-entities were additionally compared with the entire control group. We observed no statistically significant association between cumulative asbestos exposure and the risk of any lymphoma subtype. An elevated risk was found for the association between exposure to more than 2.6 fiber-years and multiple myeloma (OR = 6.0; 95% CI 1.4-25.1); however, numbers were small (n = 3 cases, all of them from Italy; n = 12 control subjects). Our study does not support an association between asbestos exposure and risk of malignant lymphoma
    Type of Publication: Journal article published
    PubMed ID: 20035432
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Keywords: ENGLAND ; LYMPHOMA ; VARIANTS ; SEQUENCE ; CLUSTER ; VARIANT ; ONCOLOGY ; GENE ; RISK
    Type of Publication: Meeting abstract published
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    facet.materialart.
    Unknown
    German Medical Science; Düsseldorf, Köln
    In:  51. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie; 20060910-20060914; Leipzig; DOC06gmds085 /20060901/
    Publication Date: 2006-09-25
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Keywords: EPIDEMIOLOGY ; occupation ; LYMPHOMA ; SKIN-CANCER ; NON-HODGKINS-LYMPHOMA ; case-control study ; DIETARY FACTORS ; OCCUPATIONAL-EXPOSURE ; T-CELL LYMPHOMA ; SUN EXPOSURE ; ULTRAVIOLET-RADIATION ; sunbeds ; INDUCED IMMUNE SUPPRESSION ; VITAMIN-D STATUS ; INDUCED IMMUNOSUPPRESSION ; INCREASING INCIDENCE
    Abstract: Although some causes for malignant lymphoma are known their etiology is not well understood so far. We analyze the relationship between sun exposure and malignant lymphoma in a multicenter, population-based case-control study. Patients with malignant lymphoma (n = 710, 18-80 years) were prospectively recruited in 6 study regions in Germany. For each case, a gender, region and age-matched control was drawn from population-registers. In personal interviews, lifetime holidays spent in sunny climate, outdoor leisure activities and sunbed or sunlamp use were recorded. On basis of job task-specific supplementary questionnaires, an occupational physician assessed the cumulative working time outside. Odds ratios (OR) and 95%-confidence-intervals (CI) were calculated using conditional logistic regression analysis, adjusted for smoking and alcohol consumption. To increase statistical power, patients with specific lymphoma subentities were additionally compared with the entire control group using unconditional logistic regression. We observed a reduced overall lymphoma risk among subjects having spent vacations at sunny climates or frequently used sunbeds or sunlamps. The analysis of lymphoma subentities revealed similar results with the exception of T-NHL and follicular lymphoma which were positively associated with outdoor leisure activities. While cumulative working time outside appeared unrelated to NHL overall and most subentities, it was negatively associated with follicular lymphoma and weakly positively to HL. This data suggest that exposure to natural and artificial ultraviolet radiation may reduce the OR for lymphoma in this study population. (c) 2007 Wiley-Liss, Inc.
    Type of Publication: Journal article published
    PubMed ID: 17311289
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...