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  • 1
    ISSN: 1433-3023
    Keywords: Abdominal colposuspension ; Anterior colporrhaphy ; Stress incontinence ; Urodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Between 1985 and 1991, 88 patients underwent abdominal colposuspension and a further 50 were treated with anterior colporrhaphy. Both preoperatively and 6 months after the operation the following were evaluated: the grade of incontinence, the posterior urethral vesical angle measured by voiding cystourethrogram, and the maximum urethral closure pressure (MUCP) at rest and during stress as measured by cystometry. At 1 year the colposuspension patients had a 69% success rate and the cure rate for anterior colporrhaphy was 38%. In postoperatively continent women the urethrovesical junction was significantly better elevated above the lower edge of the symphysis than in patients where the incontinence recurred postoperatively. The higher the urethrovesical junction was suspended, the more the MUCP during stress was increased. Treatment of genuine stress incontinence is best accomplished by retropubic colposuspension, with or without anterior colporrhaphy for coexisting cystocele.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-041X
    Keywords: Drosophila grimshawi, Diptera ; Eggshell structure ; Eggshell proteins ; Cell subpopulations ; Eggshell physiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The eggshell of the Hawaiian speciesDrosophila grimshawi was analyzed in terms of its structure and biochemical composition. It is generally similar toD. melanogaster in radial structure except that the inner endochorion is relatively compact and the outer endochorion is thick (1.9 μm) and traversed by numerous 50-nm-wide aeropyles (not present inD. melanogaster). Regionally the eggshell consists of the various specialized regions, which are: the holey posterior pole; the dorsal ridge; the operculum with very tall imprint borders; the collar with discontinuous outer endochorion; the micropyle with an external eccentric hole and an internal eccentric paracrystalline region; and the four very long respiratory appendages which exhibit tightly covered surface features for underwater plastron respiration. On the basis of the above structural data we suggest that the entireD. grimshawi eggshell (various layers and specialized regions) is the product of at least eight follicle cell subpopulations. In addition, in vitro culturing with3H-proline indicates that the eggshell is made according to a strict developmental program (analogous toD. melanogaster) and consists of several proteins ranging in molecular weight from 14,000 to 37,000 daltons.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-0879
    Keywords: Renal cell carcinoma ; Prognosis ; p53 ; mdm-2 ; Survival ; Proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical course of renal cell carcinoma (RCC) is highly variable. Overexpression of the p53 protein has been suggested as a possible prognostic parameter in RCC. Overexpression of the mdm-2 oncogene product has been shown to interact with the p53 function. To investigate the immunohistochemical overexpression of mdm-2 protein in comparison with that of p53 protein in RCC, 50 nonpapillary pT3 RCCs were immunostained for p53 protein (DO-7) and mdm-2 (1172). Tumor growth fraction (Ki-67 labeling index; MIB-1) was determined by immunohistochemistry. p53 positivity was detected in 16% of tumors. mdm-2 overexpression was seen in 30% of RCCs. There was a significant association between p53 and mdm-2 immunostaining (P=0.0006), suggesting that mdm-2 protein may contribute to p53 protein stabilization in RCC. p53 overexpression was associated with a high Ki-67 LI (P=0.0002), suggesting that p53 overexpression is involved in growth control in RCC. Survival analysis showed that Ki-67 LI (P=0.04) and p53 overexpression were associated with poor prognosis (P=0.0021), whereas mdm-2 overexpression was not related to patient outcome (P=0.73). A Cox regression analysis revealed tumor stage (P〈0.001) and p53 overexpression (P〈0.05) to be independent prognostic parameters. It is concluded that p53 but not mdm-2 may be of practical relevance in predicting patient prognosis in RCC.
    Type of Medium: Electronic Resource
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