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  • 1
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    München : Urban & Fischer
    Call number: QZ4:42(5)
    Keywords: Pathology
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php
    Pages: xxvi, 1064 p. : numerous ill.
    Edition: 5., vollständig überarb. Aufl.
    ISBN: 9783437423840
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  • 2
    ISSN: 1432-2307
    Keywords: Key words  Pseudomelanosis coli ; Large bowel ; Colonic adenoma ; Apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Pseudomelanosis coli is characterized by pigment deposition in the lamina propria and caused by increased epithelial apoptosis. Pseudomelanosis coli is absent in colonic neoplasia. The aim of our studies was to investigate this phenomenon in more detail. Apoptotic fragments of epithelial cells and their distribution, cell proliferation (Ki-67, MIB 1 immunostaining), macrophages (CD68 immunostaining), Bcl-2 expression and apoptosis [terminal-deoxynucleotidyl-transferase mediated dUTP fluorescein nick end labeling (TUNEL) assay] were studied in adenomas arising in normal and melanotic colonic mucosa, in normal colonic mucosa and colonic mucosa with pseudomelanosis alone. In adenomas, we found 7.0 apoptotic bodies per 100 epithelial cells in the epithelial layer and only 0.2 apoptotic bodies per high power field (HPF) in the lamina propria. In contrast, in melanotic mucosa 1.7 apoptotic bodies per 100 epithelial cells in the epithelial layer and 2.5 per HPF in the lamina propria were found. Our results show that apoptotic fragments remain in the neoplastic (adenomatous) epithelium and do not reach (at least in higher amounts) the lamina propria. They can, therefore, not contribute to the development of pseudomelanosis in these lesions. However, macrophages are diminished in adenomas. Proliferation (Ki-67) and also Bcl-2 expression are highly increased in adenomas. The pathway of mucosal macrophages is also discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The localization of CEA in gastric carcinomata of different histological types was studied by indirect immunofluorescence. In well differentiated adenocarcinomata CEA was present on the surface of the tumor cells. CEA was absent in anaplastic cancers. Signet ring cells contained both CEA and mucus in their cytoplasm; this may indicate that signet ring cells are fairly well-differentiated tumor cells. In areas with intestinal metaplasia, CEA was detected on the luminal surface of the cells similar to a malignant tumor.
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  • 4
    ISSN: 1432-2307
    Keywords: Carcinoid ; Immunocytochemistry ; Cytokeratin ; Neuron specific enolase ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Occurrence and distribution of cytokeratin, neuron specific enolase (NSE) and actin were studied by the immunoperoxidase-antiperoxidase (PAP)-technique using specific antibodies in formalin-fixed, paraffin-embedded material from 6 cases of neurogenic appendicopathy with numerous endocrine cells in the mucosal stroma (SEC), 5 cases of microcarcinoidosis of the stomach, 12 gastrointestinal carcinoids and 4 bronchial carcinoids. Cytokeratin was detectable in all tumor cells. In addition, the epithelial endocrine cells (EEC) and the SEC of intestinal origin were cytokeratin positive. EEC, SEC and cells of microcarcinoids and carcinoids showed a positive immunoreactivity with antibodies to NSE, whereas actin antibodies did not reveal significant staining of these cells. These results strongly suggest that carcinoids of the gastrointestinal tract originate from SEC that have migrated downwards into the stroma from the epithelial layer (“Endophytie” according to Feyrter).
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  • 5
    ISSN: 1432-2307
    Keywords: Ethanol ; Alcoholic hepatitis ; Cytokines ; Adhesion molecules ; Integrins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This immunohistochemical study was designed to investigate the possible contribution to and topographical distribution of some important cytokines, such as tumour necrosis factor α (TNFα) and interleukins, in acute alcoholic hepatitis. The well-known inductive capacity of these cytokines with respect to the expression and/or up-regulation of adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1), was a further point to be studied. Moreover, the proposed induction of adhesion molecules might also be associated with the activation and attraction of a special population of inflammatory cells characteristic for alcoholic hepatitis. Frozen liver samples from patients who died with signs of acute alcoholic hepatitis were evaluated using the alkaline phosphatase anti-alkaline phosphatase immunostaining technique and also single and double indirect immunofluorescence. In acute alcoholic hepatitis TNFα could be detected predominantly in ballooned hepatocytes, which often contained alcoholic hyalin (Mallory bodies). Moreover, TNFα showed a co-distribution with ICAM-1 expressed in the membranes of hepatocytes and with the occurrence of CD11b positive polymorphonuclear leukocytes (neutrophils) suggesting a possible major role of the β2-integrin Mac-1 as a ligand for ICAM-1. No induction of ELAM-1 could be found. In alcoholic hepatitis cytokines may be responsible for the induction of the adhesion molecule ICAM-1 on hepatocytic membranes and activate a defined population of inflammatory cells, thus contributing to the characteristic histological picture of acute alcoholic hepatitis with its concentration of neutrophils especially in areas with ballooned Mallory body-containing hepatocytes. Our results are in line with clinical findings showing high levels of TNFα and interleukin-1 in sera of patients with alcoholic hepatitis and with the already reported expression of ICAM-1 on hepatocytes.
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  • 6
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Auftreten und Lokalisation eines aus normaler Colonmucosa mit Perchlorsäure extrahierbaren Antigens (NC) in benignen und malignen Colontumoren wurden mittels indirekter Immunfluorescenz untersucht und mit dem carcinoembryonalen Antigen (CEA) verglichen. In der normalen Dickdarmschleimhaut trat das NC intracellulär im sekretorischen Anteil der Becherzellen, extracellulär diffus im Schleim auf. Es kann somit als Schleimantigen angesehen werden. In Tumoren fand es sich unabhängig vom Differenzierungsgrad immer im intra- und extracellulären Schleim. In hochdifferenzierten Tumoren wurde es reichlich in Zellen gefunden, die normalen Becherzellen ähnelten. Diese Zellen sezernierten NC ins Lumen. Bezüglich des NC verhält sich der Schleim verschiedener Tumoren und der normalen Schleimhaut gleich. Es zeigt sich deutlich, daß die vom Differenzierungsgrad des Tumors abhängige CEA-Produktion von der Schleimproduktion und vom Auftreten des NC unabhängig ist. Entgegen früheren Befunden konnte CEA auch in Polypen und in der normalen Schleimhaut in der Umgebung von Carcinomen nachgewiesen werden, womit die Befunde von Burtin et al. (1972a) bestätigt werden.
    Notes: Summary Occurrence and localization of the carcinoembryonic antigen (CEA) and of a perchloric acid-soluble antigen of normal colonic mucosa (NC) were compared in polyps and carcinomas of the colon using the indirect immunfluorescence technique. NC is located in the secretory part of the goblet cells and diffusely distributed in the mucus. Therefore, it can be considered as a marker of large-bowel mucus. NC is found in all mucus-producing tumors regardless of their degree of differentiation in intra- and extracellular mucus deposits. Tumor cells which closely resemble normal goblet cells produce and secrete NC. With respect to their NC content, there is no immunologically detectable qualitative difference between the secretions of normal and of neoplastic large bowel mucosa. It is clearly shown that production and secretion of CEA is independent of mucus production and secretion. In contrast to earlier results, CEA was found in polyps and in normal mucosa surrounding the carcinoma, confirming the observations of Burtin et al. (1972a).
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  • 7
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Despite the improvement in its prognosis in most Western countries, death from colon cancer is still a major problem. In a prospectively planned observation study, a large patient collective from a single institution in Austria was analyzed in terms of the surgical approach and factors influencing survival. A total of 696 patients with colonic carcinomas were admitted to our surgical department between January 1, 1984 and December 31, 1997. Radical surgery for localized tumors was consistently performed, including wide resection margins and complete removal of the regional lymph drainage zones. Clinical, histopathologic, and therapy-related factors were examined for their influence on long-term survival by means of univariate and multivariate analysis. The overall tumor resection rate was 99.3% (691/696); complete tumor removal (R0) was possible for 84.8% (590/696) of all patients. The overall postoperative hospital mortality rate was 3.2% (22/696), and it was 1.3% (7/556) for potentially curative resections. Five- and ten-year tumor-specific survival rates for stage I to III R0 resections were 83.8% and 78.8%, respectively. Adjuvant chemotherapy reduced tumor recurrence for stage III patients by 52.4%. The depth of tumor infiltration, lymph node status, and adjuvant chemotherapy were found to have an independent influence on survival as identified by the Cox models. In conclusion, a consistent radical surgical approach for potentially curative resected colonic cancer patients had survival rates that surpassed those of most published series without sacrificing low complication rates. In addition, adjuvant chemotherapy for stage III substantially improved survival.
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    The @breast journal 4 (1998), S. 0 
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1436-3305
    Keywords: Key words: early gastric cancer ; Japanese-type radical resection ; long-term results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Background. Long-term survival following Japanese-type radical surgery for 130 consecutively performed early gastric cancers (EGC) in a single Austrian institution between January 1, 1984 and May 31, 1998 was analyzed in terms of long-term survival, postoperative morbidity, and mortality. Methods. Extended D2 lymphadenectomy as defined by the JRSGC was performed in 129 patients with EGC. The surgical process was consistent as nearly all patients were operated on by only two surgeons. Overall survival and factors influencing survival were analyzed with particular regard to the depth of tumor infiltration, histological type, tumor grading, Lauren classification, tumor diameter, macroscopic appearance, localization, and lymph node involvement. Results. Of 678 gastric cancer patients surgically treated in the mentioned period, 130 patients (19.2%) were qualified as EGC. In 70 patients the tumor was limited to the mucosa and in 60 patients the tumor had not yet invaded the submucosa. The percentage of patients with positive lymph nodes increased from 2.9% with mucosal invasion to 21.7% with submucosal tumor involvement. The overall 5- and 10-year observed survival rate, postoperative mortality not excluded, was 74.6% and 62.1%, respectively, and 91.1% and 91.1%, respectively, when calculated as tumor specific. The 5- and 10-year observed survival rate of tumors limited to the mucosa was 77.2% and 72.1%, respectively, and 98.1% and 98.1%, respectively, when calculated as tumor specific. The respective values for submucosal invasion were 71.6% and 51.7%, and 82.7% and 82.7%. Postoperative complications occurred in 17 patients (13.1%) and postoperative hospital mortality totaled 1.5% (2/130). In multivariate analysis, only lymph node metastases were found to have independent prognostic influence on survival (P 〈 0.001; hazard ratio, 8.25). Conclusion. Japanese-type radical lymph node dissection for EGC in a European surgical institution yielded long-term survival nearly identical to that reported repeatedly by Japanese authors. Postoperative morbidity and mortality was not sacrificed by our comparatively radical surgical approach.
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