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  • 1
    Keywords: CANCER ; tumor ; FOLLOW-UP ; RISK ; TIME ; INFECTION ; breast cancer ; MICROMETASTASES ; PROGNOSTIC-SIGNIFICANCE ; body mass index ; PAIN ; ISOLATED TUMOR-CELLS ; ASPIRATION ; BIOPSY MORBIDITY ; Bone marrow puncture ; DTCs ; PRIMARY SURGERY ; Side-effects
    Abstract: BACKGROUND AND AIM: In breast cancer patients, intraoperative bone marrow puncture (BMP) with positive detection of disseminated tumor cells has been reported to predict unfavorable clinical outcome due to increased risk of recurrence. In this study, we prospectively assessed BMP-associated untoward side-effects. METHODS: Fifty-eight consecutive breast cancer patients were prospectively explored after intraoperative BMP for postoperative pain (visual analogue scale, VAS) and complications in terms of infection, hematoma, and sensibility disorder. Furthermore, the impact of BMP on hospital stay duration was analyzed in 254 patients. RESULTS: In all subgroups analyzed, during five postoperative days patients complained about minor pain only at the site of BMP (VAS 〈 1) while the corresponding pain scores were significantly higher for the area of the operated breast. Post-BMP iliac crest hematomas were encountered in 13 out of 58 patients (22.4%) who were significantly older (p = 0.04), less frequently smokers (p = 0.02), and presented with higher body mass index (p = 0.01) than controls. Within the area of BMP no signs of infection or sensibility disorders were observed. Comparison of patients with and without BMP did not show any significant difference in postoperative hospital stay duration. CONCLUSION: Referring to the potential clinical benefit of intraoperative BMP its prospectively assessed adverse side-effects appear relatively mild and thus acceptable.
    Type of Publication: Journal article published
    PubMed ID: 20621481
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  • 2
    Keywords: CANCER ; MARKER ; ONCOLOGY ; MARKERS ; chemotherapy ; breast cancer ; BREAST-CANCER ; BREAST ; polymorphism
    Type of Publication: Meeting abstract published
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  • 3
    Abstract: Recently, the SNPs rs11614913 in hsa-mir-196a2 and rs3746444 in hsa-mir-499 were reported to be associated with increased breast cancer risk, and the SNP rs2910164 in hsa-mir-146a was shown to have an effect on age of breast cancer diagnosis. In order to further investigate the effect of these SNPs, we genotyped a total of 1894 breast cancer cases negative for disease-causing mutations or unclassified variants in BRCA1 and BRCA2, and 2760 controls from Germany and Italy. We compared the genotype and allele frequencies of rs2910164, rs11614913 and rs3746444 in cases versus controls of the German and Italian series, and of the two series combined; we also investigated the effect of the three SNPs on age at breast cancer diagnosis. None of the performed analyses showed statistically significant results. In conclusion, our data suggested lack of association between SNPs rs2910164, rs11614913 and rs3746444 and breast cancer risk, or age at breast cancer onset.
    Type of Publication: Journal article published
    PubMed ID: 19847796
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  • 4
    Abstract: MicroRNAs (miRNAs) are 20-22 nt non-coding RNAs which promote the degradation of target mRNAs or repression of the translation of mRNAs by sequence specific targeting. Many miRNAs are considered as oncogenes or tumor suppressors. MiR-126 and miR-335 play roles in the suppression of breast cancer metastasis by inhibiting tumor growth, proliferation, and cell invasion. The effects of SNPs within the two miRNAs are still unknown. In our study, we analyzed two SNPs, rs4636297 within miR-126 and rs41272366 within miR-335, in three study populations for a putative association with breast cancer risk. We compared the genotype and allele frequencies of rs4636297 and rs41272366 in 2854 cases versus 3188 controls of the three study populations independently and combined. None of the performed analyses showed statistically significant results. In conclusion, our data suggest that the two genetic variants within miR-126 and miR-335 are not associated with breast cancer risk.
    Type of Publication: Journal article published
    PubMed ID: 21046227
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  • 5
    ISSN: 1432-1041
    Keywords: Key words Phenylephrine ; Septicaemia; vasopressors ; alpha-adrenoceptor agonist ; haemodynamics ; blood pressure ; critical illness ; oxygen consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: To determine the response of haemodynamic and oxygen-transport parameters to phenylephrine in a dose-response fashion in septic non-hypotensive, vasodilated surgical intensive care unit (ICU) patients. Design: Prospective study. Setting: Surgical ICU of a tertiary care, university medical centre. Patients: Ten septic non-hypotensive, vasodilated surgical ICU patients. Interventions: Routine ICU monitoring, including pulmonary and radial artery catheters. Measurements: Haemodynamic and oxygen-transport measurements were taken at baseline and during therapy. Phenylephrine was infused intravenously for 3 h at progressively increasing doses of 0.5, 1.0, 2.0, 3.0, 4.0, and 8.0 μg · kg−1 · min−1 at 30-min intervals. Measurements were taken after each dose. Results: Mean arterial pressure (MAP) and systemic vascular resistance (SVRI) increased linearly with phenylephrine dose. Cardiac index and pulmonary artery occlusion pressures did not change. Statistically significant changes were observed in heart rate, MAP, stroke index, and systemic and pulmonary vascular resistance. Eight patients had a clinically significant increase (〉15%) in oxygen consumption (VO2I). Oxygen delivery (D2OI) increased in only three patients. Serum lactate concentrations were unchanged or lower at the end of the study in all eight pateints, who displayed a 15% increase in VO2I. Conclusions: Treatment with phenylephrine increased expected haemodynamic parameters in a linear fashion; however, clinical changes in VO2I occurred at variable doses. Dose-response trials are needed to determine the optimal dose of phenylephrine. Further study is needed to evaluate the clinical effects of phenylephrine in septic patients.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 105 (1975), S. 283-293 
    ISSN: 1432-072X
    Keywords: Achlya ; Aplanopsis ; Pythium ; Saprolegnia ; Oomycetes ; Cytology ; Gametangial meiosis ; Polyploidy ; Cytotaxonomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Evidence is presented for gametangial meiosis in six Oomycetes. Particular attention is drawn to late meiotic prophase stages (pachytene-diplotene) in which chromomeres and paired homologues can be seen. One of these Oomycetes has been shown to have an abortive meiosis. Multiple chromosome associations (quadrivalent configurations, with some trivalent and univalent configurations) at first metaphase with unequal divisions at first telophase or second metaphase suggest that autopolyploidy is to be found in several species. Allopolyploidy is suspected at intermediate levels of ploidy. Basic chromosome numbers of n=3 for Achlya and n=10 for Pythium are proposed.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-069X
    Keywords: Keratinocyte ; Chemokine ; HuGRO ; IL-8 ; g-IP-10 ; Skin inflammation ; Northern blotting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract HuGRO, IL-8 and γ-IP-10 belong to a recently described superfamily of genes encoding a group of cytokines with inflammatory, growth regulating and/or leukocyte chemotactic properties (chemokines). We studied huGRO, IL-8 and γ-IP-10 gene expression in unstimulated and stimulated (TNFα, INFγ, TNFα + IFNγ, IL-1Β, PMA and LPS) normal human keratinocytes by Northern blot analysis. The mRNA for none of the three chemokines was detectable in unstimulated keratinocytes, but considerably elevated levels of huGRO and IL-8 mRNA, but not of γ-IP-10 mRNA, were found in the presence of cycloheximide, indicating that huGRO and IL-8 mRNA, but not γ-IP-10 mRNA, are constitutively produced. γ-IP-10 mRNA was exclusively induced by IFNγ, with a strong and transient rise between 8 and 18 h, and superinduced by the combination of IFNγ and TNFα, indicating marked synergism. Both huGRO and IL-8 mRNA were induced by TNFα and PMA (a strong and transient rise between 2 and 8 h), but not by IFNγ or LPS. The combination of TNFα and IFNγ did not show a synergistic effect. In addition, IL-1Β transiently upregulated huGRO mRNA but failed to induce IL-8 mRNA. Using specific oligonucleotides for α, Β and γ huGRO, TNFα was found to induce all three forms, α and Β to an equal extent and γ to a lesser extent. Our results indicate that there is stimulus-specific transcription of these early response genes which may have important implications for the modulation of cutaneous inflammatory processes.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 875-875 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Some Saprolegniaceae such as Leptolegnia baltica Hohnk and Vallin2 appear to be adapted to life in slightly saline (46/00) conditions. Te Strake3 states that the Saprolegniaceae which she isolated from estuarine water of salinity up to 2.80/00 would tolerate greater salinities in vegetative culture ...
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A description is given of the anatomy of the extrinsic and intrinsic muscles of the forelimb of the babirusa (Babyrousa babyrussa, L. 1758). Three adult animals, two males and a female were dissected and the results compared with the previously published information. Significant differences were found between the accounts, and these were analysed within the contexts of material availability and advances in anatomical nomenclature. Comparisons made with published descriptions of the pig (Sus scrofa) showed that the muscular anatomies of the two species are very similar. Four structures are present in the babirusa but not in the pig; the M. pronator teres is completely tendinous, a tendon branch from the Caput craniale m. extensor digitorum lateralis anastomoses with the tendon of the Caput intermedium m. extensor digitorum communis to the fourth digit, there is an additional small deep portion of the M. supraspinatus and a bundle of fibres from the M. pectoralis profundus inserts on the Intersectio clavicularis. Four structures present in the pig but not the babirusa are an additional insertion from the M. cleido-occipitalis into the raphe of the neck, and extra medial insertion of the M. infraspinatus, the accessory tendinous origin of the M. flexor digitorum profundus and the ulnar head of the M. flexor carpi ulnaris.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1442-1984
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The biennial to short-lived wintergreen perennial Cochlearia officinalis L. s.l. (basic chromosome number x = 6) encompasses a group of closely related taxa that is difficult to delimitate morphologically. Despite a lack of distinct sets of discontinuous morphological characters, at least six numerically different cytotypes have commonly been recognized, and they have different ecologic distributions. Evolution of the wide ploidy level was likely brought about by hybridization and polyploidization. Because plants are short-lived, seed germination was established and was likely to favor subsequent establishment. Therefore, shoot growth of juveniles was also compared. Five ecologically allopatric populations of C. officinalis s.l., each supposedly representing a different cytotype, were sampled for flowering shoots and seeds to establish shoot morphological traits, germination capabilities and chromosome number. The sampled populations differed in chromosome number: 2n = 2x = 12 (diploid); 2n = 4x = 24 (tetraploid); 2n = 33; 2n = 6x = 36 (hexaploid); and 2n = 8x = 48 (octaploid), representing the taxa C. pyrenaica DC, C. officinalis L. s.s., C. danica L. ×C. officinalis L. s.s., C. x hollandica Henrard and C. anglica L., respectively. All cytotypes produced abundant seeds and seed weight was proportional to the ploidy level. Seed weight of the diploid C. pyrenaica did not follow this correlation. Germination capacity immediately after seed collection was high over a wide temperature range. Germination was non-photoblastic. High germination capability accentuated the short-lived life-cycles of the five cytotypes. Seed germination of the coastal cytotypes (C. x hollandica and C. anglica) were less negatively affected by NaCl compared to the non-coastal cytotypes (C. pyrenaica and C. officinalis s.s.) and the very rare coastal hybrid C. danica×C. officinalis s.s. The cytotypes differed markedly in growth characteristics but there was no simple relationship between them. Increases in ploidy level were not paralleled by increased shoot growth. The hexaploid hybrid C. x hollandica indicated hybrid vigor in both shoot growth (yield) and petiole length of the strongly ascending leaves. Leaves of C. anglica were arranged in a prostratous rosette and the difference in shoot architecture between both C. x hollandica and C. anglica may be one of the reasons why this species is being replaced by the hexaploid hybrid, if sympatric, in coastal regions of The Netherlands. The 2n = 33-hybrid C. danica×C. officinalis s.s. showed no such heterosis effects in shoot growth characteristics.
    Type of Medium: Electronic Resource
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