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  • 1
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  DAV 2007; 25. Jahrestagung der deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung; 20070110-20070113; St. Anton am Arlberg; DOC07dav70 /20080625/
    Publication Date: 2008-06-25
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  GMS Krankenhaushygiene Interdisziplinär; VOL: 1; DOC19 /20060830/
    Publication Date: 2006-08-31
    Description: With a combination of photodynamic therapy using the photosensitizer toluidine blue O plus the antiseptic octenisept, it is possible to attain a sufficient bacterial-count reduction with simultaneous low cytotoxicity to human skin cells. This novel concept may find application in various clinical areas, for instance, in burn medicine or in killing antibiotic-resistant pathogens. Using the strategy we developed, it may be possible to prevent the development of resistence to a broad spectrum of pathogens due to too-frequent use of systemic antibiotics, reserving these for life-threatening infections.
    Description: Durch gezielte Kombination einer photodynamischen Therapie unter Verwendung des Photosensibilisators Toluidinblau O mit dem Antiseptikum Octenisept ist es möglich, eine suffiziente Keimzahlreduktion bei gleichzeitig geringer Zytotoxizität für Zellen der menschlichen Haut zu erzielen. Dieses neuartige Konzept könnte in verschiedenen klinischen Bereichen, wie z.B. der Verbrennungsmedizin oder der Abtötung Antibiotika-resistenter Krankheitserreger Anwendung finden. Mit dieser von uns entwickelten Strategie könnte einer Resistenzentwicklung eines breiten Spektrums pathogener Erreger aufgrund eines zu häufigen Einsatzes systemischer Antibiotika vorgebeugt und diese für lebensbedrohende Infektionen reserviert werden.
    Keywords: ddc: 610
    Language: German
    Type: article
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  • 3
    ISSN: 1432-0843
    Keywords: Chemomodulation ; Multidrug resistance ; Lymphatic leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reduced drug accumulation may be one reason for intrinsic drug resistance in chronic lymphatic leukemia of the B-cell type (B-CLL). Immunophenotyped leukemic human B-cells from 38 cases of B-CLL were characterized for P-glycoprotein (PGP) content. In all, 30 cases of B-CLL were additionally analyzed for further parameters: accumulation of daunorubicin (DNR,n=20) and rhodamine 123 (Rh123,n=30) in both the presence and the absence of verapamil (VRP). Also, 16 cases of B-CLL were analyzed for vincristine (VCR) accumulation with or without VRP. Concerning the relative expression of PGP, these 16 cases of B-CLL were representative for the whole group of 30 cases. Spontaneous accumulation of Rh123 and VCR varied over a wide range: accumulation of Rh123, by a factor of 11.8; accumulation of VCR, by a factor of 9.7; and accumulation of DNR, by a factor of 3.6. VRP modulated the accumulation of RH123 in 16/30 cases (53%), that of VCR in 69% of cases, and that of DNR in 11% of cases. The maximal VRP-mediated increases in accumulation amounted to factors of 1.3 for DNR, 2.3 for Rh123, and 7.8 for VCR. Spontaneous drug accumulation did not correlate with the extent of chemomodulation. The amount of PGP in B-CLL cells (all cases studied were PGP-positive) did not correlate with drug accumulation or with the extent of VRP-mediated chemomodulation. Thus, high expression of PGP is only partially responsible for defective drug accumulation in B-CLL. Only the degree of chemomodulation by VRP is predictive for the extent of the PGP-related functional drug accumulation defect. Thus, in B-CLL, PGP-independent drug accumulation defects seem to be as important as those mediated by PGP. The extent of this drug accumulation defect varies for the different drugs in the following order VCR〉Rh123〉DNR. The relevance of PGP-mediated and-independent drug accumulation defects in vivo may depend to a large extent on the drug being used and on the individual cell type. Both types of defect in drug accumulation are of high importance when regimens include VCR a drug commonly used in second-line chemotherapy of B-CLL. Both defects in drug accumulation may be responsible for intrinsic VCR resistance in B-CLL.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0843
    Keywords: Key words: Chemomodulation – Multidrug resistance – Lymphatic leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Reduced drug accumulation may be one reason for intrinsic drug resistance in chronic lymphatic leukemia of the B-cell type (B-CLL). Immunophenotyped leukemic human B-cells from 38 cases of B-CLL were characterized for P-glycoprotein (PGP) content. In all, 30 cases of B-CLL were additionally analyzed for further parameters: accumulation of daunorubicin (DNR, n = 20) and rhodamine 123 (Rh123, n = 30) in both the presence and the absence of verapamil (VRP). Also, 16 cases of B-CLL were analyzed for vincristine (VCR) accumulation with or without VRP. Concerning the relative expression of PGP, these 16 cases of B-CLL were representative for the whole group of 30 cases. Spontaneous accumulation of Rh123 and VCR varied over a wide range: accumulation of Rh123, by a factor of 11.8; accumulation of VCR, by a factor of 9.7; and accumulation of DNR, by a factor of 3.6. VRP modulated the accumulation of RH123 in 16/30 cases (53%), that of VCR in 69% of cases, and that of DNR in 11% of cases. The maximal VRP-mediated increases in accumulation amounted to factors of 1.3 for DNR, 2.3 for Rh123, and 7.8 for VCR. Spontaneous drug accumulation did not correlate with the extent of chemomodulation. The amount of PGP in B-CLL cells (all cases studied were PGP-positive) did not correlate with drug accumulation or with the extent of VRP-mediated chemomodulation. Thus, high expression of PGP is only partially responsible for defective drug accumulation in B-CLL. Only the degree of chemomodulation by VRP is predictive for the extent of the PGP-related functional drug accumulation defect. Thus, in B-CLL, PGP-independent drug accumulation defects seem to be as important as those mediated by PGP. The extent of this drug accumulation defect varies for the different drugs in the following order VCR〉Rh123〉DNR. The relevance of PGP-mediated and -independent drug accumulation defects in vivo may depend to a large extent on the drug being used and on the individual cell type. Both types of defect in drug accumulation are of high importance when regimens include VCR a drug commonly used in second-line chemotherapy of B-CLL. Both defects in drug accumulation may be responsible for intrinsic VCR resistance in B-CLL.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1433-7347
    Keywords: Key words Synovectomy ; Rheumatoid arthritis ; Photodynamic laser therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Notes: Abstract The introduction of arthroscopic techniques has improved the surgical therapy of rheumatoid arthritis. The additional application of the holmium:yttrium aluminum garnet (Ho:YAG) laser likewise holds great promise by providing complete hemorrhagic control. Unfortunately, a minimally invasive solution for use in smaller joints has not yet emerged. The present study describes the possible treatment of these joints by means of photodynamic laser therapy. Cell culture studies with human synovial fibroblasts obtained from patients with rheumatoid arthritis have demonstrated a cytotoxic effect after administration of Photosan-3 as a photosensitizer and subsequent laser irradiation at 630 nm. For the in vivo studies, IgG-induced arthritis in rabbits, which is histologically consistent with the proliferative phase of rheumatoid arthritis, was used as the animal model. The histologic picture following photodynamic laser therapy with Photosan-3 revealed complete synovial destruction which also extended to the border of the subjacent joint capsule. In contrast, bradytrophic structures, e.g. cartilage, menisci, and ligaments, remained unchanged at both the macroscopic and microscopic levels. Therefore, photodynamic laser therapy can be considered a new method in the surgical treatment of inflammatory disease of the synovial membrane. It has the advantage of being minimally invasive, while offering a high degree of efficacy and selectivity.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Mycopathologia 2 (1940), S. 28-36 
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In a systematic study of about 300 supposedly anascosporogenous yeast cultures it was found that nine strains actually did form ascospores. A further investigation of these strains, together with a comparative study of evidently closely related asporogenous strains, led to the following results. Mycocandida pinoyisimilis (A. Cast.) Red. et Cif. var. Citelliana Red. et Gif. proved to be identical with Saccharomyces fragilis Jörgensen. Monilia pseudotropicalis A. Cast. = Candida pseudotropicalis (A. Cast.) Basgal has to be considered as the imperfect stage of Saccharomyces fragilis Jörgensen. Monilia macedoniensis A. Cast. = Blastodendrion macedoniense (A. Cast.) Lang, et Guerra, as well as the variety macedoniensoides [= Candida macedoniensis (A. Cast.) Berkh. var. macedoniensoides (A. Cast.) Westerdijk], should in future be designated as: Saccharomyces macedoniensis Diddens et Lodder. The yeast incorrectly named by Beijerinck: Saccharomyces fragrans proved to be the imperfect stage of Saccharomyces macedoniensis Diddens et Lodder. Hence the correct designation of the species in question appears to be: Candida macedoniensis (A. Cast.) Berkh. Monilia javanica Went et Prinsen Geerligs proved to be identical with Hansenula anomala (Hansen) Sydow. A Monilia species isolated by Molle from „intertrigo blastomicetico” proved to be identical with Hansenula javanica (Groenewege) Dekker. Candida pelliculosa Red. is the imperfect stage of the last mentioned species. A strain received from Ota, and labeled: Myceloblastanon gifuense Taniguchi — which, however, did not answer the diagnosis of this species — proved to be identical with Debaryomyces Matruchoti Grigoraki et Péju.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Antonie van Leeuwenhoek 7 (1941), S. 7-11 
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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