Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 0584-8539
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1041
    Keywords: Acetyl-L-carnitine ; renal impairment ; pharmacokinetics ; adverse reactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acetyl-L-carnitine 1.5 g and 3.0 g was administered as three divided doses on each of two occasions to 24 people with varying renal failure (creatinine clearance 127 – 8 ml·min−1). Plasma and urinary concentrations of total-L-carnitine, free (non-esterified) carnitine, short-chain esters and acetyl-L-carnitine were measured. The baseline (pre-study) concentrations of all four substances were related to renal function. Patients whose creatinine clearance was below about 30–40 ml·min−1 were had the highest concentrations. Renal elimination of all four substances was related to dose and to renal function. There was evidence for dose-related elimination, with greater elimination of the larger dose.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-1041
    Keywords: Ximoprofen ; pharmacokinetics ; normal subjects ; hepatic disease ; renal disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of ximoprofen, a potent new non-steroidal anti-inflammatory agent, has been investigated in normal healthy subjects and in patients with hepatic or renal disease. After intravenous infusion of 22.8 mg to healthy subjects, plasma ximoprofen concentrations declined in a polyexponential manner with a terminal phase half-life of 1.9 h. The systemic clearance of ximoprofen was 115 ml·min−1 and the volumes of distribution were 18.0 l Vz and 13.8 l Vss. Ximoprofen was 80–90% bound to plasma proteins. The systemic availabilities (f) of orally and rectally administered doses of 30 mg of ximoprofen were 98% and 56% respectively and, in the case of the rectal dose, absorption appeared to be prolonged leading to “flip-flop” kinetics. After single oral doses of 30 mg of ximoprofen to patients with hepatic disease, half-life (2.2 h), peak plasma concentrations (1.55 μg·ml−1 cf 1.04 μg·ml−1 in healthy subjects) and areas under the curve (6.12 μg·h·ml−1 cf 3.54 μg·h·ml−1 in healthy subjects) were significantly different from those in healthy subjects. After single oral doses of 30 mg of ximoprofen to patients with renal disease, pharmacokinetic parameters of half-life (4.0 h), mean residence time (6.0 h) and area under the curve (9.2 μg·h·ml−1) were significantly different from those in healthy subjects. There were no significant differences in pharmacokinetic parameters between patients having differing degrees of renal disease. These data nevertheless suggest that accumulation of ximoprofen in hepatic or renal disease would be of slight or negligible clinical relevance and that no alteration of the dose regimen (up to 15 mg twice daily) may be required when ximoprofen is administered in these disease states.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-1041
    Keywords: amlodipine ; pharmacokinetics ; renal-impairment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Amlodipine was administered as 14 single 5-mg oral daily doses to 27 male subjects with renal function ranging from normal to haemodialysis-dependent. Blood specimens were obtained for measurement of plasma amlodipine concentrations for 24 h following the first dose, for 168 h following the final dose and during daily administration of amlodipine. Amlodipine was well tolerated. Renal impairment had little effect on the pharmacokinetics of amlodipine. The elimination half-life was of the order of 50 h, similar to previously reported values and did not vary with renal function. Steady-state pre-dose concentrations were observed after the ninth dose. Accumulation of amlodipine was not significantly different from that expected on theoretical grounds and did not significantly change with renal function. These results suggest that once daily administration of amlodipine is suitable for all degrees of renal function and that dosage adjustment is not necessary in renal impairment.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-2242
    Keywords: Reciprocal translocation ; Autotetraploid ; Chromosome pairing ; Simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Reciprocal translocations in autotetraploids create extremely complex cytological and genetic situations. Along with three types of heterozygotes with one, two or three pairs of translocated chromosomes, a large array of aneuploid and unbalanced genotypes can be expected in the F2 and advanced generations. These types arise from gametes formed by adjacent and anomalous disjunctions of multivalents and by numerical non-disjunction of non-cooriented multivalents. To determine the expected patterns of meiotic chromosome pairing configurations in all of these genotypes without the use of a computer program that constructs all possible pairing configurations, and recognizes and sums both the individual meiotic figures (univalents, rod and ring bivalents etc.) and combinations of meiotic figures, would be a very difficult task. The program has been used to construct all the possible meiotic configurations for a large array of normal and translocated genotypes with five, six, seven, eight, nine or ten chromosomes. Several inferences about the behavior of translocated chromosomes in autotetraploid populations have been drawn.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 71 (1986), S. 585-594 
    ISSN: 1432-2242
    Keywords: Autosyndesis ; Cytological diploidization ; Tetraploids ; Quadrivalents ; Experimental evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Allotetraploidization is the creation of synthetic allotetraploids. The allotetraploidization of maize can be accomplished by concentrating DPA (differential pairing affinity) factors into stocks by a recurrent selection breeding system. Selection is based on pairing configuration frequencies and altered genetic ratios that reflect DPA. Both an observed decline in the quadrivalent frequency per meiocyte from 8.10 to 7.31 and genetic data disclosing a reduction in the average frequency of recessive waxy (wx wx) pollen from Wx Wx wx wx plants from 17.48% to 13.35%, indicate considerable progress has been made toward allotetraploidization. A simple model for the effect of DPA on chromosome pairing and genetic ratios is presented.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-2242
    Keywords: Autotetraploidy ; Quadrivalents ; Aneuploidy ; Heterosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Almost all autotetraploids produce aneuploid progeny because of irregularities at meiosis. Aneuploid plants produce high frequencies of aneuploids. If it were not for selection against aneuploid gametes and sporophytes the amount of aneuploidy would increase every generation. Most experimental and theoretical studies on population genetics and heterosis in autotetraploids have neglected aneuploidy as a factor. To take aneuploidy into account experimentally requires the cytological identification of all chromosomes and to consider it theoretically requires a huge amount of computations. Consequently, microcomputer programs have been devised to show the effects of random mating and self-fertilization in autotetraploid populations. According to the model aneuploidy rapidly increases in randomly mated and self-fertilized autotetraploid populations until they achieve an equilibrium where the amount of aneuploidy introduced into the population is balanced by the amount of aneuploidy removed from the population by selection. The model suggests that self-fertilized populations have greater frequencies of aneuploid gametes and zygotes than do randomly mated populations and therefore aneuploidy may be a significant cause of the great inbreeding depressions found in autotetraploids.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 79 (1990), S. 145-152 
    ISSN: 1432-2242
    Keywords: Maize ; Allotetraploidization ; Trisomes ; Synapsis ; Zygomeres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Artificial allotetraploidization is the derivation of synthetic allotetraploids. In an allotetraploid, chromosomes of similar genomes pair with their homologues in similar genomes rather than with their homoeologues in the dissimilar genomes. The basis of this discrimination is not completely understood because the mechanisms of chromosome pairing are not adequately known. Sybenga has hypothesized the existence of special units of DNA (zygomeres) that are responsible for the initiation of synapsis of chromosomes during meiosis. Zygomeres, if they exist, should be detectable by preferential pairing studies. In the work reported here, trisome 3 maize plants had two standard chromosomes 3 marked with the genes al sh2 or al Sh2, and an odd chromosome 3 from a commercial inbred line (or derivatives thereof) marked with the dominant alleles A1 Sh2. In a previous study, three inbred lines (B41, Hy, and 38-11) were found to have chromosomes 3 that caused a great amount of preferential pairing. It may be assumed that they have different zygomeres than those of the standard chromosome 3. Hybrids between these inbred lines and hybrids between the inbreds and the standard were used as the donors of the odd chromosome. Segregation for preferential pairing (and presumably for zygomeres) was observed. The data can be explained on the basis of only two zygomeres per chromosome. Zygomeres should be able to be mapped as though they were genes.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-2242
    Keywords: Key words Centromere ; Telocentric ; Secondary trisomic ; Maize ; RFLP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The centromere of maize chromosome 4 was previously localized to a 26-cM interval using molecular markers and B-A translocations. The objective of the present study was to refine the placement of the centromere using secondary trisomics. Two independently isolated secondary trisomics (having an isochromosome plus two normal homologs) for 4S were recovered. RFLP analysis of populations segregating for them placed the centromere of chromosome 4 between bnl15.45 and bnl7.20, two RFLP loci that are 5.4-cM apart on the UMC map and 11.5-cM apart on the BNL map.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 54 (1979), S. 103-112 
    ISSN: 1432-2242
    Keywords: Trisomes ; Tetraploids ; Preferential pairing ; Synapsis ; Experimental evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Allotetraploidization is the creation of artificial allotetraploids. Allotetraploidization of maize can be achieved by restructuring a maize genome so that its chromosomes will not pair with those of the normal maize genome. The restructuring can be done by concentrating induced or naturally occurring visible and cryptic chromosome aberrations and qualitatively different genetic material into a single line by a recurrent selection type of breeding program. The basis of allotetraploidization is the presence of differential pairing affinity between normal and restructured chromosomes. Experiments demonstrate that differential pairing affinity factors occur naturally in exotic races and in standard corn belt inbred lines and that they may be readily induced by X-irradiation and chemical mutagens.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...