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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 434 (2005), S. 287-288 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The gene encoding the p53 protein is mutated in more than 50% of human cancers, but quite how it is involved in tumour biology has eluded scientists for decades. Studies in Cell by Olive et al. and Lang et al., of genetically engineered p53 mutant proteins in mice, underscore the complexity ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 385 (1997), S. 637-640 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Bax is a Bcl-2 related protein that promotes apoptosis in cultured cells2. Mice deficient in Bax have selective hyperplasias and show resistance to certain apoptotic stimuli3. As p53 activity correlates with increased Bax expression4'5 and activates expression through p53-responsive elements in the ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7373
    Keywords: brain tumor ; choroid plexus carcinoma ; ependymoma ; SV40 T antigen ; folate binding protein ; SV11 mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A high affinity folate receptor is expressed in some human cancers,including choroid plexus tumors and ependymomas, and has been suggested as a target for therapeutics. In this report, the expression of folate receptors in an SV40 large T antigen transgenicmouse (SV11) was investigated. SV11 mice develop choroid plexus tumors, a property that may be related to the observation that SV40 has been isolated from human choroid plexus tumors and ependymomas. We report that SV11 choroid plexus tumors containa high affinity folate receptor (D of 1 nM), detectable by 125I-folate autoradiography and immunohistochemistry.Western blot analysis indicated an apparent molecular weight of 38 kDa.RT-PCR revealed the presence of transcripts for bothalpha and beta isoforms of the folate receptor. Brain parenchyma hasundetectable folate receptor, but normal choroid plexus has substantiallevels (as does human choroid plexus). The folate receptors of the tumorare accessible from the bloodstream whereasthose of the normal choroid plexus are not. Thus SV11 transgenic mice should be useful for evaluating therapeutic targeting of high affinity folate receptors, both for efficacy of specific agents andpossible side effects.
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