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  • 1
    Publication Date: 2012-09-22
    Description: Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic brain architecture. Here we describe the generation and analysis of a transcriptional atlas of the adult human brain, comprising extensive histological analysis and comprehensive microarray profiling of approximately 900 neuroanatomically precise subdivisions in two individuals. Transcriptional regulation varies enormously by anatomical location, with different regions and their constituent cell types displaying robust molecular signatures that are highly conserved between individuals. Analysis of differential gene expression and gene co-expression relationships demonstrates that brain-wide variation strongly reflects the distributions of major cell classes such as neurons, oligodendrocytes, astrocytes and microglia. Local neighbourhood relationships between fine anatomical subdivisions are associated with discrete neuronal subtypes and genes involved with synaptic transmission. The neocortex displays a relatively homogeneous transcriptional pattern, but with distinct features associated selectively with primary sensorimotor cortices and with enriched frontal lobe expression. Notably, the spatial topography of the neocortex is strongly reflected in its molecular topography-the closer two cortical regions, the more similar their transcriptomes. This freely accessible online data resource forms a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243026/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243026/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawrylycz, Michael J -- Lein, Ed S -- Guillozet-Bongaarts, Angela L -- Shen, Elaine H -- Ng, Lydia -- Miller, Jeremy A -- van de Lagemaat, Louie N -- Smith, Kimberly A -- Ebbert, Amanda -- Riley, Zackery L -- Abajian, Chris -- Beckmann, Christian F -- Bernard, Amy -- Bertagnolli, Darren -- Boe, Andrew F -- Cartagena, Preston M -- Chakravarty, M Mallar -- Chapin, Mike -- Chong, Jimmy -- Dalley, Rachel A -- Daly, Barry David -- Dang, Chinh -- Datta, Suvro -- Dee, Nick -- Dolbeare, Tim A -- Faber, Vance -- Feng, David -- Fowler, David R -- Goldy, Jeff -- Gregor, Benjamin W -- Haradon, Zeb -- Haynor, David R -- Hohmann, John G -- Horvath, Steve -- Howard, Robert E -- Jeromin, Andreas -- Jochim, Jayson M -- Kinnunen, Marty -- Lau, Christopher -- Lazarz, Evan T -- Lee, Changkyu -- Lemon, Tracy A -- Li, Ling -- Li, Yang -- Morris, John A -- Overly, Caroline C -- Parker, Patrick D -- Parry, Sheana E -- Reding, Melissa -- Royall, Joshua J -- Schulkin, Jay -- Sequeira, Pedro Adolfo -- Slaughterbeck, Clifford R -- Smith, Simon C -- Sodt, Andy J -- Sunkin, Susan M -- Swanson, Beryl E -- Vawter, Marquis P -- Williams, Derric -- Wohnoutka, Paul -- Zielke, H Ronald -- Geschwind, Daniel H -- Hof, Patrick R -- Smith, Stephen M -- Koch, Christof -- Grant, Seth G N -- Jones, Allan R -- 066717/Wellcome Trust/United Kingdom -- 077155/Wellcome Trust/United Kingdom -- 1C76HF15069-01-00/PHS HHS/ -- 1C76HF19619-01-00/PHS HHS/ -- G0700399/Medical Research Council/United Kingdom -- G0802238/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2012 Sep 20;489(7416):391-9. doi: 10.1038/nature11405.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Allen Institute for Brain Science, Seattle, Washington 98103, USA. mikeh@alleninstitute.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22996553" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Anatomy, Artistic ; Animals ; *Atlases as Topic ; Brain/*anatomy & histology/cytology/*metabolism ; Calbindins ; Databases, Genetic ; Dopamine/metabolism ; *Gene Expression Profiling ; Health ; Hippocampus/cytology/metabolism ; Humans ; In Situ Hybridization ; Internet ; Macaca mulatta/anatomy & histology/genetics ; Male ; Mice ; Neocortex/anatomy & histology/cytology/metabolism ; Oligonucleotide Array Sequence Analysis ; Post-Synaptic Density/genetics ; RNA, Messenger/analysis/genetics ; S100 Calcium Binding Protein G/genetics ; Species Specificity ; Transcriptome/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2011-02-11
    Description: Electrical stimulation of certain hypothalamic regions in cats and rodents can elicit attack behaviour, but the exact location of relevant cells within these regions, their requirement for naturally occurring aggression and their relationship to mating circuits have not been clear. Genetic methods for neural circuit manipulation in mice provide a potentially powerful approach to this problem, but brain-stimulation-evoked aggression has never been demonstrated in this species. Here we show that optogenetic, but not electrical, stimulation of neurons in the ventromedial hypothalamus, ventrolateral subdivision (VMHvl) causes male mice to attack both females and inanimate objects, as well as males. Pharmacogenetic silencing of VMHvl reversibly inhibits inter-male aggression. Immediate early gene analysis and single unit recordings from VMHvl during social interactions reveal overlapping but distinct neuronal subpopulations involved in fighting and mating. Neurons activated during attack are inhibited during mating, suggesting a potential neural substrate for competition between these opponent social behaviours.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075820/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075820/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Dayu -- Boyle, Maureen P -- Dollar, Piotr -- Lee, Hyosang -- Lein, E S -- Perona, Pietro -- Anderson, David J -- Howard Hughes Medical Institute/ -- England -- Nature. 2011 Feb 10;470(7333):221-6. doi: 10.1038/nature09736.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology 216-76, California Institute of Technology, 1201 East California Boulevard, Pasadena, California 91125, USA. dayu.lin@nyumc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21307935" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*physiology ; Animals ; Electric Stimulation ; Electrophysiology ; Female ; Gene Expression Regulation ; Genes, fos/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neural Inhibition/genetics/physiology ; Neural Pathways/physiology ; Neurons/physiology ; Sexual Behavior, Animal/physiology ; Ventromedial Hypothalamic Nucleus/anatomy & ; histology/*cytology/metabolism/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2014-04-04
    Description: The anatomical and functional architecture of the human brain is mainly determined by prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the mid-gestational human brain, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions. In developing cerebral cortex, transcriptional differences are found between different proliferative and post-mitotic layers, wherein laminar signatures reflect cellular composition and developmental processes. Cytoarchitectural differences between human and mouse have molecular correlates, including species differences in gene expression in subplate, although surprisingly we find minimal differences between the inner and outer subventricular zones even though the outer zone is expanded in humans. Both germinal and post-mitotic cortical layers exhibit fronto-temporal gradients, with particular enrichment in the frontal lobe. Finally, many neurodevelopmental disorder and human-evolution-related genes show patterned expression, potentially underlying unique features of human cortical formation. These data provide a rich, freely-accessible resource for understanding human brain development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105188/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105188/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Jeremy A -- Ding, Song-Lin -- Sunkin, Susan M -- Smith, Kimberly A -- Ng, Lydia -- Szafer, Aaron -- Ebbert, Amanda -- Riley, Zackery L -- Royall, Joshua J -- Aiona, Kaylynn -- Arnold, James M -- Bennet, Crissa -- Bertagnolli, Darren -- Brouner, Krissy -- Butler, Stephanie -- Caldejon, Shiella -- Carey, Anita -- Cuhaciyan, Christine -- Dalley, Rachel A -- Dee, Nick -- Dolbeare, Tim A -- Facer, Benjamin A C -- Feng, David -- Fliss, Tim P -- Gee, Garrett -- Goldy, Jeff -- Gourley, Lindsey -- Gregor, Benjamin W -- Gu, Guangyu -- Howard, Robert E -- Jochim, Jayson M -- Kuan, Chihchau L -- Lau, Christopher -- Lee, Chang-Kyu -- Lee, Felix -- Lemon, Tracy A -- Lesnar, Phil -- McMurray, Bergen -- Mastan, Naveed -- Mosqueda, Nerick -- Naluai-Cecchini, Theresa -- Ngo, Nhan-Kiet -- Nyhus, Julie -- Oldre, Aaron -- Olson, Eric -- Parente, Jody -- Parker, Patrick D -- Parry, Sheana E -- Stevens, Allison -- Pletikos, Mihovil -- Reding, Melissa -- Roll, Kate -- Sandman, David -- Sarreal, Melaine -- Shapouri, Sheila -- Shapovalova, Nadiya V -- Shen, Elaine H -- Sjoquist, Nathan -- Slaughterbeck, Clifford R -- Smith, Michael -- Sodt, Andy J -- Williams, Derric -- Zollei, Lilla -- Fischl, Bruce -- Gerstein, Mark B -- Geschwind, Daniel H -- Glass, Ian A -- Hawrylycz, Michael J -- Hevner, Robert F -- Huang, Hao -- Jones, Allan R -- Knowles, James A -- Levitt, Pat -- Phillips, John W -- Sestan, Nenad -- Wohnoutka, Paul -- Dang, Chinh -- Bernard, Amy -- Hohmann, John G -- Lein, Ed S -- 5R24HD0008836/HD/NICHD NIH HHS/ -- R00 HD061485/HD/NICHD NIH HHS/ -- R01 MH092535/MH/NIMH NIH HHS/ -- R24 HD000836/HD/NICHD NIH HHS/ -- RC2 MH089921/MH/NIMH NIH HHS/ -- RC2MH089921/MH/NIMH NIH HHS/ -- England -- Nature. 2014 Apr 10;508(7495):199-206. doi: 10.1038/nature13185. Epub 2014 Apr 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Allen Institute for Brain Science, Seattle, Washington 98103, USA [2]. ; Allen Institute for Brain Science, Seattle, Washington 98103, USA. ; Division of Genetic Medicine, Department of Pediatrics, University of Washington, 1959 North East Pacific Street, Box 356320, Seattle, Washington 98195, USA. ; 1] Department of Radiology, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA [2] Computer Science and AI Lab, MIT, Cambridge, Massachusetts 02139, USA. ; Department of Neurobiology and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, Connecticut 06510, USA. ; Department of Radiology, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. ; 1] Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA [2] Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA. ; Program in Neurogenetics, Department of Neurology and Semel Institute David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA. ; 1] Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington 98101, USA [2] Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98105, USA. ; Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas 75390, USA. ; Zilkha Neurogenetic Institute, and Department of Psychiatry, University of Southern California, Los Angeles, California 90033, USA. ; 1] Department of Pediatrics, Children's Hospital, Los Angeles, California 90027, USA [2] Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24695229" target="_blank"〉PubMed〈/a〉
    Keywords: Anatomy, Artistic ; Animals ; Atlases as Topic ; Brain/embryology/*metabolism ; Conserved Sequence/genetics ; Fetus/cytology/embryology/*metabolism ; Gene Expression Regulation, Developmental/*genetics ; Gene Regulatory Networks/genetics ; Humans ; Mice ; Neocortex/embryology/metabolism ; Species Specificity ; *Transcriptome
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2013-12-20
    Description: We present a high-quality genome sequence of a Neanderthal woman from Siberia. We show that her parents were related at the level of half-siblings and that mating among close relatives was common among her recent ancestors. We also sequenced the genome of a Neanderthal from the Caucasus to low coverage. An analysis of the relationships and population history of available archaic genomes and 25 present-day human genomes shows that several gene flow events occurred among Neanderthals, Denisovans and early modern humans, possibly including gene flow into Denisovans from an unknown archaic group. Thus, interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene. In addition, the high-quality Neanderthal genome allows us to establish a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031459/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031459/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prufer, Kay -- Racimo, Fernando -- Patterson, Nick -- Jay, Flora -- Sankararaman, Sriram -- Sawyer, Susanna -- Heinze, Anja -- Renaud, Gabriel -- Sudmant, Peter H -- de Filippo, Cesare -- Li, Heng -- Mallick, Swapan -- Dannemann, Michael -- Fu, Qiaomei -- Kircher, Martin -- Kuhlwilm, Martin -- Lachmann, Michael -- Meyer, Matthias -- Ongyerth, Matthias -- Siebauer, Michael -- Theunert, Christoph -- Tandon, Arti -- Moorjani, Priya -- Pickrell, Joseph -- Mullikin, James C -- Vohr, Samuel H -- Green, Richard E -- Hellmann, Ines -- Johnson, Philip L F -- Blanche, Helene -- Cann, Howard -- Kitzman, Jacob O -- Shendure, Jay -- Eichler, Evan E -- Lein, Ed S -- Bakken, Trygve E -- Golovanova, Liubov V -- Doronichev, Vladimir B -- Shunkov, Michael V -- Derevianko, Anatoli P -- Viola, Bence -- Slatkin, Montgomery -- Reich, David -- Kelso, Janet -- Paabo, Svante -- 59107334/Howard Hughes Medical Institute/ -- GM100233/GM/NIGMS NIH HHS/ -- HG002385/HG/NHGRI NIH HHS/ -- HG006283/HG/NHGRI NIH HHS/ -- R01 GM040282/GM/NIGMS NIH HHS/ -- R01 GM100233/GM/NIGMS NIH HHS/ -- R01 HG002385/HG/NHGRI NIH HHS/ -- R01 HG006283/HG/NHGRI NIH HHS/ -- R01-GM40282/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2014 Jan 2;505(7481):43-9. doi: 10.1038/nature12886. Epub 2013 Dec 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany. ; Department of Integrative Biology, University of California, Berkeley, California 94720-3140, USA. ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA. ; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. ; Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA. ; 1] Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany [2] Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China. ; 1] Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany [2] Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA. ; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. ; Genome Technology Branch and NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. ; Department of Biomolecular Engineering, University of California, Santa Cruz, California 95064, USA. ; 1] Max F. Perutz Laboratories, Mathematics and Bioscience Group, Campus Vienna Biocenter 5, Vienna 1030, Austria [2] Ludwig-Maximilians-Universitat Munchen, Martinsried, 82152 Munich, Germany. ; Department of Biology, Emory University, Atlanta, Georgia 30322, USA. ; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain (CEPH), 75010 Paris, France. ; 1] Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA [2] Howard Hughes Medical Institute, Seattle, Washington 98195, USA. ; Allen Institute for Brain Science, Seattle, Washington 98103, USA. ; ANO Laboratory of Prehistory 14 Linia 3-11, St. Petersburg 1990 34, Russia. ; Palaeolithic Department, Institute of Archaeology and Ethnography, Russian Academy of Sciences, Siberian Branch, 630090 Novosibirsk, Russia. ; Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany. ; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24352235" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; Caves ; DNA Copy Number Variations/genetics ; Female ; *Fossils ; Gene Flow/genetics ; Gene Frequency ; Genome/*genetics ; Heterozygote ; Humans ; Inbreeding ; Models, Genetic ; Neanderthals/classification/*genetics ; Phylogeny ; Population Density ; Siberia/ethnology ; Toe Phalanges/anatomy & histology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2014-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Francis S -- Heimer, Hakon -- Giedd, Jay N -- Lein, Edward S -- Sestan, Nenad -- Weinberger, Daniel R -- Casey, B J -- New York, N.Y. -- Science. 2014 Oct 31;346(6209):547-9. doi: 10.1126/science.1260497.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sackler Institute, Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA. ; Schizophrenia Research Forum, Brain and Behavior Research Foundation, Providence, RI 02906, USA. Banbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. ; Division of Child and Adolescent Psychiatry, University of California, San Diego, CA 92123, USA. ; Allen Institute for Brain Science, Seattle, WA 98103, USA. ; Department of Neurobiology and Psychiatry, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA. ; Lieber Institute for Brain Development, Baltimore, MD 21205, USA. Department of Psychiatry, Neurology, Neuroscience, and the Institute of Genomic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 20215, USA. ; Sackler Institute, Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA. bjc2002@med.cornell.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25359951" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; *Adolescent Behavior ; *Adolescent Development ; Age of Onset ; Brain/*growth & development/physiology ; *Early Medical Intervention ; Humans ; Mental Disorders/diagnosis/epidemiology/*prevention & control ; *Mental Health ; National Institutes of Health (U.S.)/economics ; Neuroimaging ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Li, M., Santpere, G., Imamura Kawasawa, Y., Evgrafov, O. V., Gulden, F. O., Pochareddy, S., Sunkin, S. M., Li, Z., Shin, Y., Zhu, Y., Sousa, A. M. M., Werling, D. M., Kitchen, R. R., Kang, H. J., Pletikos, M., Choi, J., Muchnik, S., Xu, X., Wang, D., Lorente-Galdos, B., Liu, S., Giusti-Rodriguez, P., Won, H., de Leeuw, C. A., Pardinas, A. F., Brain; Span Consortium, Psych; ENCODE Consortium, Psych; ENCODE Developmental Subgroup, Hu, M., Jin, F., Li, Y., Owen, M. J., ODonovan, M. C., Walters, J. T. R., Posthuma, D., Levitt, P., Weinberger, D. R., Hyde, T. M., Kleinman, J. E., Geschwind, D. H., Hawrylycz, M. J., State, M. W., Sanders, S. J., Sullivan, P. F., Gerstein, M. B., Lein, E. S., Knowles, J. A., Sestan, N., Willsey, Oldre, Szafer, Camarena, Cherskov, Charney, Abyzov, Kozlenkov, Safi, Jones, Ashley-Koch, Ebbert, Price, Sekijima, Kefi, Bernard, Amiri, Sboner, Clark, Jaffe, Tebbenkamp, Sodt, Guillozet-Bongaarts, Nairn, Carey, Huttner, Chervenak, Szekely, Shieh, Harmanci, Lipska, Carlyle, Gregor, Kassim, Sheppard, Bichsel, Hahn, Lee, Chen, Kuan, Dang, Lau, Cuhaciyan, Armoskus, Mason, Liu, Slaughterbeck, Bennet, Pinto, Polioudakis, Franjic, Miller, Bertagnolli, Lewis, Feng, Sandman, Clarke, Williams, Del; Valle, Fitzgerald, Shen, Flatow, Zharovsky, Burke, Olson, Fulfs, Mattei, Hadjimichael, Deelman, Navarro, Wu, Lee, Cheng, Goes, Vaccarino, Liu, Hoffman, Gürsoy, Gee, Mehta, Coppola, Giase, Sedmak, Johnson, Wray, Crawford, Gu, van Bakel, Witt, Yoon, Pratt, Zhao, Glass, Huey, Arnold, Noonan, Bendl, Jochim, Goldy, Herstein, Wiseman, Miller, Mariani, Stoll, Moore, Szatkiewicz, Leng, Zhang, Parente, Rozowsky, Fullard, Hohmann, Morris, Phillips, Warrell, Shin, An, Belmont, Nyhus, Pendergraft, Bryois, Roll, Grennan, Aiona, White, Aldinger, Smith, Girdhar, Brouner, Mangravite, Brown, Collado-Torres, Cheng, Gourley, Song, Ubieta, Habegger, Ng, Hauberg, Onorati, Webster, Kundakovic, Skarica, Reimers, Johnson, Chen, Garrett, Sarreal, Reding, Gu, Peters, Fisher, Gandal, Purcaro, Smith, Brown, Shibata, Brown, Xu, Yang, Ray, Shapovalova, Francoeur, Sjoquist, Mastan, Kaur, Parikshak, Mosqueda, Ngo, Dee, Ivanov, Devillers, Roussos, Parker, Manser, Wohnoutka, Farnham, Zandi, Emani, Dalley, Mayani, Tao, Gittin, Straub, Lifton, Jacobov, Howard, Park, Dai, Abramowicz, Akbarian, Schreiner, Ma, Parry, Shapouri, Weissman, Caldejon, Mane, Ding, Scuderi, Dracheva, Butler, Lisgo, Rhie, Lindsay, Datta, Souaiaia, Roychowdhury, Gomez, Naluai-Cecchini, Beach, Goodman, Gao, Dolbeare, Fliss, Reddy, Chen, Hyde, Brunetti, Lemon, Desta, Borrman, Haroutunian, Spitsyna, Swarup, Shi, Jiang, Xia, Chen, Jiang, Wang, Chae, Yang, Kim, Riley, Krsnik, Deng, Weng, Lin, Li
    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-12-14
    Description: To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type–specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C , SATB2 , SOX5 , TCF4 , and TSHZ3 ) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks.
    Keywords: Neuroscience, Online Only
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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