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    Publication Date: 2015-06-25
    Description: An epidemic of Ebola virus disease of unprecedented scale has been ongoing for more than a year in West Africa. As of 29 April 2015, there have been 26,277 reported total cases (of which 14,895 have been laboratory confirmed) resulting in 10,899 deaths. The source of the outbreak was traced to the prefecture of Gueckedou in the forested region of southeastern Guinea. The virus later spread to the capital, Conakry, and to the neighbouring countries of Sierra Leone, Liberia, Nigeria, Senegal and Mali. In March 2014, when the first cases were detected in Conakry, the Institut Pasteur of Dakar, Senegal, deployed a mobile laboratory in Donka hospital to provide diagnostic services to the greater Conakry urban area and other regions of Guinea. Through this process we sampled 85 Ebola viruses (EBOV) from patients infected from July to November 2014, and report their full genome sequences here. Phylogenetic analysis reveals the sustained transmission of three distinct viral lineages co-circulating in Guinea, including the urban setting of Conakry and its surroundings. One lineage is unique to Guinea and closely related to the earliest sampled viruses of the epidemic. A second lineage contains viruses probably reintroduced from neighbouring Sierra Leone on multiple occasions, while a third lineage later spread from Guinea to Mali. Each lineage is defined by multiple mutations, including non-synonymous changes in the virion protein 35 (VP35), glycoprotein (GP) and RNA-dependent RNA polymerase (L) proteins. The viral GP is characterized by a glycosylation site modification and mutations in the mucin-like domain that could modify the outer shape of the virion. These data illustrate the ongoing ability of EBOV to develop lineage-specific and potentially phenotypically important variation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simon-Loriere, Etienne -- Faye, Ousmane -- Faye, Oumar -- Koivogui, Lamine -- Magassouba, Nfaly -- Keita, Sakoba -- Thiberge, Jean-Michel -- Diancourt, Laure -- Bouchier, Christiane -- Vandenbogaert, Matthias -- Caro, Valerie -- Fall, Gamou -- Buchmann, Jan P -- Matranga, Christan B -- Sabeti, Pardis C -- Manuguerra, Jean-Claude -- Holmes, Edward C -- Sall, Amadou A -- England -- Nature. 2015 Aug 6;524(7563):102-4. doi: 10.1038/nature14612. Epub 2015 Jun 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France [2] CNRS URA3012, Paris 75015, France. ; Institut Pasteur de Dakar, Arbovirus and Viral Hemorrhagic Fever Unit, BP 220, Dakar, Senegal. ; Institut National de Sante Publique de Guinee, Conakry, Guinea. ; Projet de fievres hemorragiques de Guinee, Universite Gamal Abdel Nasser, BP 1147, Conakry, Guinea. ; Ministry of Health, BP 585 Conakry, Guinea. ; Institut Pasteur, Unite Environnement et Risques Infectieux, Cellule d'Intervention Biologique d'Urgence, 75724 Paris Cedex 15, France. ; Institut Pasteur, Genomic platform, 75724 Paris Cedex 15, France. ; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006, Australia. ; Broad Institute, 75 Ames Street, Cambridge, Massachusetts 02142, USA. ; 1] Broad Institute, 75 Ames Street, Cambridge, Massachusetts 02142, USA [2] FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, 52 Oxford Street, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26106863" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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