Springer Online Journal Archives 1860-2000
Energy, Environment Protection, Nuclear Power Engineering
Abstract Organochlorine insecticide (OCI) and chlorinated biphenyl (CB) blood residues were measured in 29 men with oligoastenospermia and in 14 matched control subjects. Although both OCI and CB residue levels were generally low, infertile patients, in comparison with healthy individuals, exhibited significantly higher levels ofp,p′-DDT metabolites in the blood, as well as elevated residues of lindane, tetra- and penta-CBs. These increases were found more frequently in patients with oligospermia (spermatozoa count below 20 million/mL) than in those with astenospermia and normal counts. However, residue levels ofo,p′-DDD and heptachlor epoxide were lower in the study group than in the control group. Correlations between DDT isomers and metabolites and other OCI blood residues were stronger in infertile patients than in the control group, whereas OCI-CB correlations were weaker in the study group. There are several possible mechanisms of Organochlorine compound interference with male fertility functions.
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