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  • 1
    Call number: M120:162
    Type of Medium: Book
    Pages: 235 p. : , ill.
    Edition: 3. Aufl.
    ISBN: 9783832172039
    Language: German
    Location: DKFZ
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  • 2
    ISSN: 1432-1041
    Keywords: Key words Asthma therapy ; Corticosteroids; hospitalisation ; case-control study ; compliance ; attitude ; behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Background: The relationship between therapy and adverse outcome in asthma is debated especially for naturally occurring situations. This is due in part to insufficient information regarding actual use of medications. Objective: This study was conducted to clarify the relationship between actual intake of anti-asthma drugs and asthma hospitalisation, considered as an outcome. Methods: A case-control study was performed. Patients hospitalised for an asthma exacerbation were matched to community controls identified in surrounding general practices. Patients were questioned to identify prior use of anti-asthma medications, level of use of inhaled corticosteroids and attitude towards therapy. Results: Twenty-three cases and 31 matched controls were interviewed. Cases tended to have more severe asthma than controls, as judged by more frequent use of oral corticosteroids. Cases tended to make more frequent use of oral xanthines and inhaled anticholinergics, but the proportion of patients using inhaled β2-adrenoceptor agonists and inhaled corticosteroids was similar in both groups. Use of lower doses of inhaled corticosteroids was associated with an increased risk of hospitalisation, while higher dosage was associated with␣decreased risk. Cases and controls differed as to their answers to a questionnaire concerning attitudes: cases expressed less interest in optimal usage of inhaled␣corticosteroids than controls; they also expressed more confidence in inhaled β2-agonists. When both risks were combined, overconfidence in β2-agonists and suboptimal use of inhaled steroids, the relationship with hospitalisation was significant (OR 5.5, 95% CI 1.1; 26.1). Conclusion: The results suggest that patients' attitudes to inhaled corticosteroids and actual consumption of these medications are directly related to adverse outcome in asthma.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 359 (1973), S. 185-200 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 2 Patienten im Alter von 3 8/12 bzw. 27 Jahren entwickelte sich nach Anlegen eines ventriculo-atrialen Shunt eine diffuse Glomerulonephritis mit nephrotischem Syndrom. Die Entfernung des Shunt führte beim ersten Patienten zu einer raschen Besserung und beim zweiten Patienten zu einer kompletten Heilung des Nierenleidens. Das anfänglich tiefe Serumkomplement (β1C) normalisierte sich. Bei dem Kinde konnte aus dem Liquor und vom Ventil Staphylococcus albus gezüchtet werden. Bei dem erwachsenen Patienten blieben die Kulturen steril. Beim ersten Patienten ergab die Nierenbiopsie vor Entfernung des Shunt eine diffuse intra- und extracapilläre Glomerulonephritis, Typ III (subakute Glomerulonephritis), beim zweiten eine diffuse intracapilläre proliferative und exsudative Glomerulonephritis. Bei beiden Patienten wurde 22, bzw. 7 Monate nach Entfernung des Shunt eine zweite Biopsie entnommen. Beim ersten Fall waren rund die Hälfte der Glomeruli hyalinisiert. Die übrigen zeigten mäßig ausgeprägte segmentäre Läsionen. Halbmonde waren keine mehr nachweisbar. Beim zweiten Patienten bestand nach 7 Monaten noch eine deutliche mesangiale Proliferation mit Lobulierung der Glomeruli. Immunfluorescenzmikroskopisch konnte in beiden Fällen in den Glomerulusschlingen IgG, IgM und β1C in grob granulärer Form nachgewiesen werden. Elektronenmikroskopisch fanden sich bei beiden Patienten auch in der zweiten Biopsie subendotheliale Ablagerungen. Die nach einem infizierten ventriculo-atrialen Shunt auftretende Glomerulonephritis ist mit großer Wahrscheinlichkeit durch Immunkomplexe bedingt. Da durch Entfernung des Shunt das Antigen sofort entfernt werden kann, ist selbst bei schweren Nierenläsionen eine weitgehende Besserung möglich.
    Notes: Summary Diffuse glomerulonephritis with the nephrotic syndrome was observed in two patients aged 3 years 8 months and 27 years, both of whom had ventriculo-atrial shunts. Removal of the shunts resulted in marked improvement in the first and complete recovery in the second patient. Serum β1C-globulin concentrations were initially low and returned to normal values. Cultures taken from cerebrospinal fluid and valve grew Staphylococcus albus in the pediatric patient and were negative in the adult patient. Initial renal biopsies obtained immediately before shunt removal showed diffuse intra- and extracapillary glomerulonephritis type III (crescent formation in over 90 percent of the glomeruli) in the first patient, and diffuse intracapillary proliferative and exudative glomerulonephritis in the second patient. Repeat biopsies were performed, on the first patient 22 months, and on the second patient 7 months after shunt removal. In the first patient, half of the glomeruli were sclerosed, and the others exhibited slight mesangial proliferation with some capsular adhesions. The repeat renal biopsy from the adult patient showed mesangial proliferation with lobulation. Immunofluorescence studies in both patients revealed positive staining in a coarsely granular pattern against IgG, IgM, and β1C globulin. On electron microscopy, subendothelial deposits were still visible in the second biopsies of both patients. Glomerulonephritis associated with infected ventriculo-atrial shunt is probably mediated by antigen-antibody complexes. Recovery is possible in spite of severe renal lesions since the antigen can be eliminated at once by removal of the shunt.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of immunotherapy with high dose (50×106 units/m2) recombinant leukocyte A interferon on blood monocyte functions was studied in eight patients with bronchogenic carcinoma. Monocyte chemotactic responsiveness (MCR) was initially depressed (9.8±1.6 cells/field) compared to healthy controls (17.6±5.1 cells/field), P〈0.01. Recombinant interferon was administered three times weekly, and after 7 days a significant improvement in chemotaxis was observed (16.6±3.0 cells/field), P〈0.05. The MCR remained normal until cessation of interferon therapy (〉1 month). Phagocytic and candidacidal activities were normal in the patients and were not influenced by treatment with interferon. In conclusion, high dose recombinant interferon given to cancer patients caused a normalization of defective blood monocyte chemotaxis, which persisted for 〉1 month.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-086X
    Keywords: Atherosclerosis ; Stent ; Intimal hyperplasia ; Prophylaxis ; Contrast radiation, afterloading technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Recurrent stenosis or occlusion by intimal hyperplasia occurs in up to 40% of patients with tantalum stent implantations in femoropopliteal arteries and greatly restricts their usefulness. We evaluated the effect of prophylactic endovascular radiotherapy on stenosed/occluded\ stents. Methods: We investigated prophylactic endovascular radiotherapy with a surface dose of 12 Gy using an iridium 192 source as a means to reduce or eliminate recurrent stenosis in 4 patients with stenosed/occluded stents, 6–8 months after the original implantation. Confirmatory diagnostic atherectomy, PTA or laser recanalization and endovascular radiotherapy were performed. Results: None of the four has developed recurrent obstruction within 23 to 30 months after this treatment, which up to now shows no short-term or long-term complications. Conclusion: We conclude that this limited experience is promising enough to warrant further study.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-086X
    Keywords: Atherosclerosis ; Stent ; Intimal hyperplasia ; Prophylaxis ; Contrast radiation, afterloading technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Recurrent stenosis or occlusion by intimal hyperplasia occurs in up to 40% of patients with tantalum stent implantations in femoropopliteal arteries and greatly restricts their usefulness. We evaluated the effect of prophylactic endovascular radiotherapy on stenosed/occluded\ stents. Methods: We investigated prophylactic endovascular radiotherapy with a surface dose of 12 Gy using an iridium 192 source as a means to reduce or eliminate recurrent stenosis in 4 patients with stenosed/occluded stents, 6–8 months after the original implantation. Confirmatory diagnostic atherectomy, PTA or laser recanalization and endovascular radiotherapy were performed. Results: None of the four has developed recurrent obstruction within 23 to 30 months after this treatment, which up to now shows no short-term or long-term complications. Conclusion: We conclude that this limited experience is promising enough to warrant further study.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The1H-NMR-spectra of 1,2-alkyl-phenyl-hydrazines inDMSO exhibit a distinct solvent differentiation of the two nonequivalent NH groups thus offering a practical method of characterizing and distinguishing compounds of this type from 1,1-disubstituted hydrazines.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Integral equations and operator theory 10 (1987), S. 236-257 
    ISSN: 1420-8989
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Here we present a new solution procedure for Helmholtz and Laplacian Neumann screen or Dirichlet screen problems in IR3 via boundary integral equations of the first kind having as unknown the jump of the field or of its normal derivative, respectively, across the screen S. Under the assumption of local finite energy we show the equivalence of the integral equations and the original boundary value problems. Via the Wiener-Hopf method in the halfspace, localization and the calculus of pseudodifferential operators we derive existence, uniqueness and regularity results for the solution of our boundary integral equations together with its explicit behavior near the edge of the screen. We give Galerkin schemes based on our integral equations on S and obtain high convergence rates by using special singular elements besides regular splines as test and trial functions.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1420-8989
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this paper we analyze the solution of crack problems in three-dimensional linear elasticity by equivalent integral equations of the first kind on the crack surface. Besides existence and uniqueness we give sharp regularity results for the solution of these pseudodifferential equations. Two versions of Eskin's Wiener-Hopf technique are presented: the first one requires the factorization of matrix-valued symbols which is avoided in the second case. Based on these regularity results we show how to improve the boundary element Galerkin method for our integral equations by using special singular trial functions. We apply the approximation property and inverse assumption of these elements together with duality arguments and derive quasi-optimal asymptotic error estimates in a scale of Sobolev spaces.
    Type of Medium: Electronic Resource
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