Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Amino acids can be identified unambiguously in form of their dansylated methyl esters by combination of thin-layer chromatography on polyamide and subsequent mass spectrometry without prior substance elution from the chromatographic polyamide carrier. The evaporation intensity of the amino acid derivatives is sufficient to get excellent mass spectra with significant structural information also with very small amounts of starting material (picomole level), which guarantee a high separation power in the TLC step. Besides the methylester derivatives, in part, products additionally methyl substituted at the sulfonamide nitrogen could be separated.
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