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  • 1
    Call number: Z070:338
    Pages: 231 p. : ill.
    Edition: 4., überarb. und erw. Aufl.
    ISBN: 978-3-8007-3375-0
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    Z070:338 departmental collection or stack – please contact the library
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  • 2
    Keywords: Medicine ; Immunology ; Microbiology ; Medical virology ; Biomedicine ; Immunology ; Medical Microbiology ; Virology ; Springer eBooks
    Description / Table of Contents: IgM and IgD in infection and inflammatory diseases -- Immunoglobulin A – molecular mechanisms of function and role in immune defense -- Crystal structures of human IgG Fc-fragments and their complexes with Fc Receptors -- The role of IgG in immune responses -- Molecular and cellular pathways involved in the anti-inflammatory activity of IgG -- Example of the Pathogenic Potential of Two Sets of Autoantibodies: Anti-RBC and IgG3 RF Cryoglobulins -- Cross-talk between antibodies, IgG Fc receptors and the complement system -- Regulation of immunological responses by the neonatal Fc receptor for IgG, FcRn -- Antibody mediated regulation of humoral immunity -- Engineered antibody derivatives in preclinical and clinical development
    Abstract: This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand
    Pages: : digital.
    ISBN: 9781461471073
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  • 3
    Unknown
    Heidelberg : Verlag f. Medizin Fischer
    Call number: QZ200:391
    Keywords: Tumor / Pädiatrie ; Leukämie / Pädiatrie ; Tumor / Information
    Pages: 128 S.
    ISBN: 3-88463-133-0
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    QZ200:391 available
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  • 4
    Unknown
    New York, N.Y. : Oxford University Press
    Call number: 01-AUSBILDUNGSL:441
    Keywords: USA ; United States ; Civilization ; United States ; Geography
    Pages: p. cm.
    ISBN: 0194342352
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    01-AUSBILDUNGSL:441 departmental collection or stack – please contact the library
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  • 5
    Unknown
    Braunschweig : Westermann
    Call number: 01-Ausbildungsl:650
    Pages: 387 p. : ill.
    Edition: 5. Aufl.
    ISBN: 3-14-225025-5
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  • 6
    Call number: M220:39
    Pages: xii,247 p.
    Edition: 5., völlig neu bearb. Aufl. 2008, printed 2016.
    ISBN: 9783791016009
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  • 7
    Keywords: Life sciences ; Landscape ecology ; Ecology ; Conservation biology ; Wildlife management ; Nature conservation ; Life sciences ; Landscape ecology ; Theoretical Ecology/Statistics ; Fish & Wildlife Biology & Management ; Conservation Biology/Ecology ; Nature conservation ; Community & Population Ecology ; Springer eBooks
    Pages: : digital
    ISBN: 9781441973900
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  • 8
    Unknown
    Cham : Springer International Publishing
    Keywords: Medicine ; Immunology ; Cell receptors ; Biomedicine ; Immunology ; Receptors ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: The Old but New IgM Fc Receptor -- Emerging Roles for FCRL Family Members in Lymphocyte Biology and Disease -- Intracellular antibody immunity and the cytosolic Fc receptor TRIM21 -- Computational modeling of the main signaling pathways involved in mast cell activation -- Calcium channels in FcR signaling -- Regulation of FcæRI signaling by lipid phosphatases -- Fc Receptors as Adaptive Immunoreceptors -- Glycosylation and Fc Receptors -- Antibodies as natural adjuvants -- IgA, IgA receptors and their anti-inflammatory properties -- Humanized mice to study FcR function -- FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions -- Human FcR polymorphism and disease -- Bridging auto-antibodies and arthritis; the role of Fc Receptors -- The FcR of humans and non-human primates and their interaction with IgG: Implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies -- FcgRIIB as a key determinant of agonistic antibody efficacy -- Fc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work -- Sweet and Sour: The role of glycosylation for the anti-inflammatory activity of immunoglobulin G
    Abstract: This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcæR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcæRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcRIIB and FcRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes
    Pages: XV, 424 p. 55 illus., 44 illus. in color. : online resource.
    ISBN: 9783319079110
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  • 9
    Call number: YY Diss Weih/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 106 p.
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  • 10
    Unknown
    Tokyo : Springer Japan
    Keywords: Life sciences ; Oceanography ; Animal ecology ; Biodiversity ; Aquatic biology ; Zoology ; Nature conservation ; Life sciences ; Biodiversity ; Nature conservation ; Animal ecology ; Oceanography ; Freshwater & Marine Ecology ; Zoology ; Springer eBooks
    ISBN: 9784431540069
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