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  • 1
    Keywords: Medicine ; Forensic Medicine ; Forensic Medicine ; Public health laws ; Biomedicine ; Forensic Science ; Forensic Medicine ; Medical Law ; Springer eBooks
    Description / Table of Contents: Present and future perspectives for Medical Malpractice, Responsibility and Liability -- Historical Overview of Medical Liability -- Praxis et Mala-Praxis Medica -- European legislative and juridical overview -- Causal value and causal link -- Medical Responsibility and Liability in German-speaking Countries - Austria, Germany, and Switzerland -- Medical Responsibility and Liability in the United Kingdom -- Medical Responsibility and Liability in France -- Medical Responsibility and Liability in Spain -- Medical Responsibility and Liability in Portugal -- Medical Responsibility and Liability in Italy -- Medical Responsibility and Liability in Lithuania, Latvia, and Estonia -- Medico-Legal Methods of Ascertainment and Criteria of Evaluation in Medical Responsibility and Liability -- Requirements and Final Recommendations -- Historical Iconography from the Vincenzo Pinali Antique Medical Library
    Abstract: Medical responsibility lawsuits have become a fact of life in every physician's medical practice. However, there is evidence that physicians are increasingly practicing defensive medicine, ordering more tests than may be necessary and avoiding patients with complicated conditions. Modern medical practice is increasingly complicated by factors beyond the traditional realm of patient care, including novel technologies, loss of physician autonomy, and economic pressures. A continuing and significant issue affecting physicians and the healthcare system is malpractice. In the latter half of the 20th century, there was a major change in the attitude of the public towards the medical profession. People were made aware of the huge advances in medical technology, because health problems have increasingly tended to attract media interest and wide publicity. Medicine is a victim of its own success in this respect, and people are now led to expect the latest techniques and a perfect outcome on every occasion. This burst of technology and hyper-specialization in many fields of medicine means that each malpractice claim is transformed into a scientific challenge, requiring specific preparation in the analysis and judgment of the clinical case in question. The role of legal medicine has become increasingly specific in this judicial setting, often giving rise to erroneous interpretations and hasty scientific verdicts, but guidelines on the methodology of ascertainments and criteria of evaluation are lacking all over the world. The aim of this book is to clarify the steps required for a sequential, in-depth analysis of events and the consequences of medical actions. This can then be used to verify whether, in the presence of damage, health professionals made errors or failed to observe rules of conduct, and which causal values and links to their possible misconduct are involved
    Pages: : digital.
    ISBN: 9783642358319
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  • 2
    Keywords: Medicine ; Gynecology ; Obstetrics ; Maternal and infant welfare ; Medical records / Data processing ; Endocrinology ; Medicine & Public Health ; Endocrinology ; Maternal and Child Health ; Obstetrics/Perinatology ; Health Informatics ; Gynecology ; Springer eBooks
    Pages: : digital
    ISBN: 9781848821200
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  • 3
    Keywords: Medicine ; Forensic Science ; Forensic Medicine ; Civil law ; Biomedicine ; Forensic Science ; Forensic Medicine ; Civil law ; Springer eBooks
    Description / Table of Contents: Part 1 -- The Holistic and Systematic Approach in Legal Medicine -- Causal Value and Causal Link -- International Juridical Overview on Personal Damage Compensation -- Part 2 -- Methods of Ascertainment of Personal Damage in Portugal -- Methods of Ascertainment of Personal Damage in Spain -- Methods of Ascertainment of Personal Damage in France -- Methods of Ascertainment of Personal Damage in Italy -- Methods of Ascertainment of Personal Damage in Belgium -- Methods of Ascertainment of Personal Damage in The Netherlands -- Methods of Ascertainment of Personal Damage in United Kingdom -- Methods of Ascertainment of Personal Damage in Germany -- Methods of Ascertainment of Personal Damage in Hungary -- Methods of Ascertainment of Personal Damage in Lithuania -- Methods of Ascertainment of Personal Damage in Estonia -- Part 3 -- Methods of Ascertainment of Personal Damage in United States of America -- Methods of Ascertainment of Dental Damage in Argentina -- Part 4 -- Methods of Ascertainment of Personal Damage in Egypt -- Methods of Ascertainment of Personal Damage in Nigeria -- Part 5 -- Methods of Ascertainment of Personal Damage in Turkey -- Methods of Ascertainment of Personal Damage in the Kingdom of Saudi Arabia -- Methods of Ascertainment of Personal Damage in India -- Methods of Ascertainment of Personal Damage in China -- Methods of Ascertainment of Personal Damage in Japan -- Methods of Ascertainment of Personal Damage in Australia -- Part 6 -- International Overview on Dental Damage Compensation -- International Comparative Epicrisis on the Ascertainment and Evaluation of Personal Injury and Damage -- Part 7 -- Physical and Biomechanical Methods of Ascertainment -- Detection of Malingering in Personal Injury and Damage Ascertainment -- A novel methodology for the objective ascertainment of Psychological€“Éxistential Damage -- International Guidelines on the Methods of Ascertainment of Personal Injury and Damage Under Civil-Tort Law -- International Guidelines on the Methods of Ascertainment of Whiplash Associated Disorders -- Part 8 -- Requirements and Final Recommendations -- Part 9 -- Historical Iconography on Personal Injury and Damage from the "Vincenzo Pinali" Antique Medical Library
    Abstract: This volume serves to provide an international overview of personal injury compensation in different geographical areas (15 countries already included), with a special focus on the methods used to ascertain the injury and the related damages. It also goes on to clarify the logical and methodological steps required for a sequential, in-depth ascertainment of any traumatic event and the related personal damage, both pecuniary and non-pecuniary. Personal injury is a legal term for an injury to the body, mind or emotions suffered by the plaintiff under tort and/or civil law regulations. Damages related to the injury can be pecuniary or non-pecuniary in nature. Although several comparative studies and research projects on tort and civil law and personal injury claims aimed at developing new tools for promoting harmonization of private law have been performed at an international level, heterogeneity and divergences still exist in the definition and compensation of personal injury and damage across different national legislative systems. The starting point for any awarding procedure should be a medical, or rather a medico-legal, assessment to gain evidence on the trauma or event causing the injury, the mechanism of injury, the pre-existing health status of the injured party, and the health consequences of the injury (temporary and permanent impairment, work incapacity, etc.). In order to pursue the ultimate goal of an international harmonization of personal injury compensation, it is of upmost importance to define the quality requirements for the medico-legal ascertainment methodology, which are essential for guaranteeing the objectivity, rigor, and reproducibility of the data and the evidence collection procedure. Currently, there are no supra-national medico-legal guidelines dealing with the ascertainment methodology of personal injury and damage under tort and civil law
    Pages: XXXVIII, 700 p. 98 illus., 34 illus. in color. : online resource.
    ISBN: 9783319298122
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  • 4
    Keywords: ANGIOGENESIS ; GROWTH ; tumor ; CELL LUNG-CANCER ; mechanisms ; chemotherapy ; MURINE MODEL ; NERVE ; BEVACIZUMAB ; HYPERALGESIA
    Abstract: Cancer pain is a debilitating disorder and a primary determinant of the poor quality of life. Here, we report a non-vascular role for ligands of the Vascular Endothelial Growth Factor (VEGF) family in cancer pain. Tumor-derived VEGF-A, PLGF-2, and VEGF-B augment pain sensitivity through selective activation of VEGF receptor 1 (VEGFR1) expressed in sensory neurons in human cancer and mouse models. Sensory-neuron-specific genetic deletion/silencing or local or systemic blockade of VEGFR1 prevented tumor-induced nerve remodeling and attenuated cancer pain in diverse mouse models in vivo. These findings identify a therapeutic potential for VEGFR1-modifying drugs in cancer pain and suggest a palliative effect for VEGF/VEGFR1-targeting anti-angiogenic tumor therapies.
    Type of Publication: Journal article published
    PubMed ID: 26058077
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  • 5
  • 6
    Keywords: EXPRESSION ; SURVIVAL ; IN-VIVO ; GENE ; GENE-EXPRESSION ; DIFFERENTIATION ; MOUSE ; HEMATOPOIETIC STEM-CELLS ; ERYTHROPOIETIN ; LINEAGE ; ALLELES ; DEFINITIVE HEMATOPOIESIS ; YOLK-SAC ; TRANSCRIPTION FACTOR GATA-1
    Abstract: To determine the role of vascular endothelial growth factor (Vegf) in embryonic erythroid development we have deleted or overexpressed Vegf specifically in the erythroid lineage using the EpoR-iCre transgenic line in combination with Cre/loxP conditional gain and loss of function Vegf alleles. ROSA26 promoter-based expression of the Vegf(164) isoform in the early erythroid lineage resulted in a differentiation block of primitive erythroid progenitor (EryP) development and a partial block in definitive erythropoiesis between the erythroid burst-forming unit and erythroid colony-forming unit stages. Decreased mRNA expression levels of the key erythroid transcription factor Gata1 were causally linked to this phenotype. Conditional deletion of Vegf within the erythroid lineage was associated with increased Gata1 levels and increased erythroid differentiation. Expression of a ROSA26-based GATA2 transgene rescued Gata1 mRNA levels and target genes and restored erythroid differentiation in our Vegf gain of function model. These results demonstrate that Vegf modulates Gata1 expression levels in vivo and provides new molecular insight into Vegf's ability to modulate erythropoiesis.
    Type of Publication: Journal article published
    PubMed ID: 20554972
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  • 7
    Abstract: Acute Graft-versus-host disease (GVHD) is a major immunological complication after allogeneic hematopoietic cell transplantation and a better understanding of the molecular regulation of the disease could help to develop novel targeted therapies. Here we found that a G/C polymorphism within the human microRNA-146a (miR-146a) gene of transplant recipients, which causes reduced miR-146a levels, was strongly associated with the risk of developing severe acute GVHD (n=289). In mice, deficiency of miR-146a in the hematopoietic system or transfer of recipient-type miR-146a(-/-) dendritic cells (DCs) enhanced GVHD, while miR-146a mimic-transfected DCs ameliorated disease. Mechanistically, lack of miR-146a enhanced JAK2-STAT1 pathway activity, which led to higher expression of class II-transactivator (CIITA) and consecutively increased MHCII-levels on DCs. Inhibition of JAK1/2 or CIITA knockdown in DCs prevented miR-146a(-/-) DC-induced GVHD exacerbation. Consistent with our findings in mice, patients with the miR-146a polymorphism rs2910164 in hematopoietic cells displayed higher MHCII levels on monocytes, which could be targeted by JAK1/2 inhibition. Our findings indicate that the miR-146a polymorphism rs2910164 identifies patients at high risk for GVHD before allo-HCT. Functionally we show that miR-146a acts as a central regulator of recipient-type DC activation during GVHD by dampening the pro-inflammatory JAK-STAT/CIITA/MHCII axis, which provides a scientific rationale for early JAK1/2 inhibition in selected patients.
    Type of Publication: Journal article published
    PubMed ID: 28484267
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  • 8
    Keywords: CANCER ; CELLS ; EXPRESSION ; proliferation ; radiotherapy ; tumor ; CELL ; Germany ; human ; TOXICITY ; NEW-YORK ; PROTEIN ; TUMORS ; PATIENT ; RESPONSES ; IFN-GAMMA ; INDUCTION ; DENDRITIC CELLS ; T cell ; T-CELL ; T-CELLS ; E7 ; papillomavirus ; IMMUNE-RESPONSES ; TARGET ; STAGE ; ASSAY ; cervical cancer ; CERVICAL-CANCER ; MARKERS ; human papillomavirus ; TYPE-16 ; GENOTYPES ; HPV ; E6 ; HPV16 ; HUMAN-PAPILLOMAVIRUS ; ONCOPROTEIN ; VACCINE ; CANCER-PATIENTS ; SAFETY ; ELISPOT ; immune response ; IMMUNE-RESPONSE ; IMMUNOTHERAPY ; vaccination ; HUMAN-PAPILLOMAVIRUS TYPE-16 ; SERIES ; CARCINOMA SCC ANTIGEN ; DE-NOVO ; E7 ONCOPROTEIN ; HLA ; IMMUNOGENICITY ; immunotherapy,ELISpot,T lymphocytes,CTL,uterine cancer ; STAGE IB ; TARGETS ; tumor marker
    Abstract: Purpose. Human papillomavirus (HPV) type 16 and 18 are the most prevalent genotypes in cervical cancer. The viral oncoproteins E6 and E7 are considered to be tumor-specific targets for immunotherapy. HPV E7 antigen-loaded autologous dendritic cells (DC) were evaluated as cellular tumor vaccine in a case series of cervical cancer patients. Methods. Autologous monocyte-derived DCs were pulsed with recombinant HPV16 E7 or HPV18 E7 oncoprotein and administered to 15 stage IV cervical cancer patients. Safety, toxicity, and induction of serological and cellular immune responses were monitored. Results. The vaccine was well-tolerated and no local or systemic side effects or toxicity were recorded. A specific serologic response was seen in 3/11 evaluated patients. Specific cellular immune responses (4/11) were detected with 2/10 positive de novo reactions plus one boosted preexistent response in proliferation assays and 3/11 in IFN-gamma ELISpot assays. A transient drop in tumor marker SCC was observed in 5/9 evaluable patients but did not correlate with markers of the immune response. No objective clinical response was observed. Tumor biopsies available from four patients showed severe or complete loss of HLA expression in three of the advanced tumors. Conclusion. Autologous dendritic cells pulsed with HPV E7 protein can induce T cell responses in a portion of late stage cervical cancer patients. Boosting of immune responses by adjuvants and vaccination of tumor HLA-positive patients will be mandatory in future trials
    Type of Publication: Journal article published
    PubMed ID: 12898233
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  • 9
    ISSN: 0168-1176
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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