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  • 1
    ISSN: 1432-1041
    Keywords: Benzodiazepine ; temazepam ; pharmacokinetics ; bioavailability ; hard and soft gelatine capsules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma levels of temazepam were determined in healthy subjects after single oral administration of soft and hard gelatin capsules, and after 7 consecutive night-time doses in soft capsules. Absorption from soft gelatin capsules was significantly faster and produced earlier and higher peak plasma levels. The two pharmaceutical forms did not show any significant difference in relative availability. The apparent half-life of temazepam after night-time administration was significantly shorter than after morning administration, but no change in half-life was observed between the first and seventh night-time doses.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1590-3478
    Keywords: decentralization ; denervation ; succinylcholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Succinylcholine, a depolarizing muscle relaxant with both activating and desensitizing effects, is used to facilitate endotracheal intubation. The activating effects were found to be above-normal on induction of anesthesia in 7 neurosurgical patients: generalized muscle spasm in 1 myotonic patient, contractures or prolonged contractions in “anatomically” denervated muscles (1 patient), in “functionally” denervated muscles (1 patient) and in “centrally” denervated muscles (4 patients). One of these four presented hyperkalemia and cardiocirculatory collapse. It is important to differentiate these anomalous responses to succinylcholine from those occurring as early signs of rhabdomyolysis or malignant hyperthermia.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1569-8041
    Keywords: abdominal surgery ; cancer in the elderly ; gastrointestinal neoplasms ; liver surgery ; surgical oncology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The geriatric population is expanding and clinical decision-making is oftencomplicated by the effects of aging. Age should not be the only parameterconsidered when addressing medical problems. Elderly subjects have been deniedsurgery because of their presumed higher mortality and morbidity. The presentreview summarises the physiology of the aged and discusses operative risks,mortality and morbidity rates as well as therapeutic results for the differentgastrointestinal sites when affected by cancer. Reports on surgical treatmentsare revisited and compared to the same procedures delivered to youngerpatients in the context of the ethical issue of offering the best care toevery patient. Elective operations by surgical oncologists are found to besafe with the exception of major liver resections. Complication rates and meanhospital stay do not differ between the two age groups provided the procedureis conducted with the best-known technique in expert hands. A drop inoperative morbidity has occurred in the past three decades. Severalinvestigators have emphasised the marked increase in morbidity and mortalityexperienced by elderly patients when undergoing emergency procedures.Associated diseases have to be properly assessed, as the aged have a frailphysiologic balance with a reduced capacity for recovery from traumatic eventsincluding major surgical procedures. Careful preoperative evaluation,intraoperative conduct and postoperative care are presently achieved in almostevery major hospital. Good clinical practice is based on the balance betweenprobability of cure and toxic effects. Treatment of the elderly should nolonger be based on untested beliefs and personal opinions. The aged should beaccrued for prospective clinical evaluation and meanwhile should not be deniedoptimal surgical treatment.
    Type of Medium: Electronic Resource
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