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  • 1
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    New York, NY : Springer
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Principles of MRI and Functional MRI -- Introduction to Functional MRI Hardware -- Selection of Optimal Pulse Sequences for fMRI -- High-Field fMRI -- Experimental Design -- Preparing fMRI Data for Statistical Analysis -- Statistical Analysis of fMRI Data -- Dynamic Causal Modeling of Brain Responses -- Brain Atlases: Their Development and Role in Functional Inference -- Graph Theoretic Analysis of Human Brain Networks -- Functional MRI: Applications in Cognitive Neuroscience -- FMRI of Language Systems -- Neuroimaging Approaches to the Study of Visual Attention -- fMRI of Memory -- fMRI of Emotion -- fMRI of Pain -- fMRI of the Sensorimotor System -- Functional Imaging of the Human Visual System -- fMRI of the Central Auditory System -- Application of fMRI to Multiple Sclerosis and Other White Matter Disorders -- fMRI in Cerebrovascular Disorders -- fMRI in Psychiatric Disorders -- fMRI in Neurodegenerative Diseases: From Scientific Insights to Clinical Applications -- fMRI in Epilepsy -- fMRI in Neurosurgery -- Pharmacological Applications of fMRI -- Application of fMRI to Monitor Motor Rehabilitation -- Multivariate Approaches for Multimodal Fusion of Structural and Functional Brain Imaging Data -- Functional MRI of the Spinal Cord -- Clinical Applications of the Functional Connectome
    Abstract: The second edition of this volume provides up-to-date methods on the main methodological aspects of functional MRI (fMRI), applying fMRI to the study of central nervous system, and future evolutions of fMRI techniques. fMRI: Method and Protocols, Second Edition guides the reader through chapters on basic knowledge for the understanding of the technical aspects of fMRI, overview of the main results derived from the application of fMRI to the study of healthy individuals, application of fMRI to assess the role of brain plasticity in the major neurological and psychiatric conditions, and novel approaches for the integration of fMRI data. Concise and easy-to-use, fMRI: Method and Protocols, Second Edition aims to be useful to clinicians and researchers with a user-friendly summary of the field and necessary background ensuring further successful studies
    Pages: XIII, 911 p. 248 illus., 112 illus. in color. : online resource.
    Edition: 2nd ed. 2016.
    ISBN: 9781493956111
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  Qualität der "Neuen" Lehre in der Medizin; Jahrestagung der Gesellschaft für Medizinische Ausbildung - GMA; 20051104-20051106; Münster; DOC05gma037 /20051026/
    Publication Date: 2005-10-27
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    Keywords: RISK ; mechanisms ; ALZHEIMERS-DISEASE ; HUNTINGTONS-DISEASE ; human brain ; AGE-RELATED-CHANGES ; OLDER-ADULTS ; VOXEL-BASED MORPHOMETRY ; FRACTIONAL ANISOTROPY ; Longitudinal study ; Cortical connectivity ; HUMAN CORPUS-CALLOSUM ; TENSOR-BASED MORPHOMETRY ; WHITE-MATTER DAMAGE
    Abstract: Cross-sectional studies using diffusion tensor imaging (DTI) suggest decline of the integrity of intracortically projecting fiber tracts with aging and in neurodegenerative diseases, such as Alzheimer's disease (AD). Longitudinal studies on the change of fiber tract integrity in normal and pathological aging are still rare. Here, we prospectively studied 11 healthy elderly subjects and 14 subjects with amnestic mild cognitive impairment (MCI), a clinical risk group for AD, using high-resolution DTI and MRI at baseline and after 13 to 16 months follow-up. Fractional anisotropy (FA), a DTI measure of fiber tract integrity, was compared across time points and groups using a repeated measures linear model and tract based spatial statistics. Additionally, we determined rates of grey matter and white matter atrophy using automated deformation based morphometry. Healthy elderly subjects showed decline of FA in intracortical projecting fiber tracts, such as corpus callosum, superior longitudinal fasciculus, uncinate fasciculus, inferior fronto-occipital fasciculus, and cingulate bundle (p 〈 0.05, corrected for multiple comparisons). MCI subjects showed significant FA decline predominantly in the anterior corpus callosum (p 〈 0.05, corrected for multiple comparisons). Grey and white matter atrophy involved prefrontal, parietal, and temporal lobe areas in controls and prefrontal, cingulate, and parietal lobe areas in MCI subjects and agreed with the pattern of fiber tract changes. Our findings indicate that DTI allows detection of microstructural changes in subcortical fiber tracts over time that are related to aging as well as to early stages of AD type neurodegeneration. The underlying mechanisms for these changes are unknown.
    Type of Publication: Journal article published
    PubMed ID: 20847446
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  • 4
    Abstract: MR imaging is widely used for the diagnosis and monitoring of patients with MS. Applications and protocols for MR imaging continue to evolve, prompting a need for continual reassessments of the optimal use of this technique in clinical practice. This article provides updated recommendations on the use of MR imaging in MS, based on a review of the trial evidence and personal experiences shared at a recent expert meeting of radiologists and neurologists.
    Type of Publication: Journal article published
    PubMed ID: 20019103
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  • 5
    Keywords: DIAGNOSIS ; imaging ; PATIENT ; TRIAL ; EXPERIENCE ; CONTRAST AGENTS ; GADOBENATE-DIMEGLUMINE ; NATURAL-HISTORY ; MULTIPLE-SCLEROSIS ; MR imaging ; review ; monitoring ; MS ; RECOMMENDATIONS ; DIAGNOSTIC-CRITERIA ; GLATIRAMER ACETATE ; NEPHROGENIC SYSTEMIC FIBROSIS ; 1ST DEMYELINATING EVENT ; CLINICALLY ISOLATED SYNDROMES ; DOSE GADOTERIDOL ; ENHANCING LESIONS
    Abstract: MR imaging is widely used for the diagnosis and monitoring of patients with MS. Applications and protocols for MR imaging continue to evolve, prompting a need for continual reassessments of the optimal use of this technique in clinical practice. This article provides updated recommendations on the use of MR imaging in MS, based on a review of the trial evidence and personal experiences shared at a recent expert meeting of radiologists and neurologists
    Type of Publication: Journal article published
    PubMed ID: 20019103
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  • 6
    Abstract: BACKGROUND: Radical local treatment of pulmonary metastases is practiced with increasing frequency due to acknowledgment and better understanding of oligo-metastatic disease. This study aimed to develop a nomogram predicting overall survival (OS) after stereotactic body radiotherapy (SBRT) for pulmonary metastases. PATIENTS AND METHODS: A multi-institutional database of 670 patients treated with SBRT for pulmonary metastases was used as training cohort. Cox regression analysis with bidirectional variable elimination was performed to identify factors to be included into the nomogram model to predict 2-year OS. The calibration rate of the nomogram was assessed by plotting the actual Kaplan-Meier 2-year OS against the nomogram predicted survival. The nomogram was externally validated using two separate monocentric databases of 145 and 92 patients treated with SBRT for pulmonary metastases. RESULTS: The median follow up of the trainings cohort was 14.3months, the 2-year and 5-year OS was 52.6% and 23.7%, respectively. Karnofsky performance index, type of the primary tumor, control of the primary tumor, maximum diameter of the largest treated metastasis and number of metastases (1 versus 〉1) were significant prognostic factors in the Cox model (all p〈0.05). The calculated concordance-index for the nomogram was 0.73 (concordance indexes of all prognostic factors between 0.54 and 0.6). Based on the nomogram the training cohort was divided into 4 groups and 2-year OS ranged between 24.2% and 76.1% (predicted OS between 30.2% and 78.4%). The nomogram discriminated between risk groups in the two validation cohorts (concordance index 0.68 and 0.67). CONCLUSIONS: A nomogram for prediction of OS after SBRT for pulmonary metastases was generated and externally validated. This tool might be helpful for interdisciplinary discussion and evaluation of local and systemic treatment options in the oligo-metastatic setting. KEY MESSAGE: A nomogram for prediction of overall survival after stereotactic body radiotherapy (SBRT) for pulmonary metastases was developed and externally validated. This tool might be helpful for interdisciplinary discussion and evaluation of local and systemic treatment options in the oligo-metastatic setting.
    Type of Publication: Journal article published
    PubMed ID: 28169042
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  • 7
    Keywords: brain ; DISEASE ; MRI ; ALZHEIMERS-DISEASE ; SCHIZOPHRENIA ; REGION ; Alzheimer's disease ; multicenter studies ; HEALTHY-VOLUNTEERS ; HUNTINGTONS-DISEASE ; Diffusion Tensor Imaging ; DTI ; early diagnosis ; FRACTIONAL ANISOTROPY ; MEAN DIFFUSIVITY ; DIAGNOSTIC UTILITY ; Effect size estimation ; Physical phantom ; TRACT INTEGRITY
    Abstract: Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans in a group of 26 patients with clinically probable Alzheimer's disease (AD) and 12 healthy elderly controls at one single center. We determined the variability of fractional anisotropy (FA) measures using manually placed regions of interest as well as automated tract based spatial statistics and deformation based analysis. The coefficient of variation (CV) of FA was 6.9% for the physical phantom data. The mean CV across the multicenter brain scans was 14% for tract based statistics, and 29% for deformation based analysis. The degree of variation was higher in less organized fiber tracts. Our findings suggest that a clinical and physical phantom study involving more than two scanners is indispensable to detect potential sources of bias and to reliably estimate effect size in multicenter diagnostic trials using DTI.
    Type of Publication: Journal article published
    PubMed ID: 22078796
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  • 8
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    German Medical Science; Düsseldorf, Köln
    In:  GMS Zeitschrift für Medizinische Ausbildung; VOL: 22; DOC94 /20051118/
    Publication Date: 2005-11-19
    Keywords: ddc: 610
    Language: German
    Type: article
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  • 9
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    German Medical Science; Düsseldorf, Köln
    In:  56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC); 20050507-20050511; Strasbourg; DOC11.05.-16.12 /20050504/
    Publication Date: 2005-05-05
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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