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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  49. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie (ÖGPÄRC), 42. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 16. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20110929-20111001; Innsbruck; DOC11dgpraecV150 /20110927/
    Publication Date: 2011-09-27
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  10. Kongress für Infektionskrankheiten und Tropenmedizin (KIT 2010); 20100623-20100626; Köln; DOCINF 13-4 /20100602/
    Publication Date: 2010-06-02
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  45. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 19. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC), 52. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie (ÖGPRÄC); 20140911-20140913; München; DOC26 /20140903/
    Publication Date: 2014-09-04
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  44. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 17. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20130912-20130914; Münster; DOCFV 68 /20130910/
    Publication Date: 2013-09-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Der Urologe 37 (1998), S. 516-521 
    ISSN: 1433-0563
    Keywords: Key words Hemorrhagic cystitis • Chemotherapy • ; Cyclophosphamide-treatment ; Schlüsselwörter Hämorrhagische Zystitis • Chemotherapie • Cyclophosphamidtherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die hämorrhagische Urozystitis als Folge der Urotoxizität von Cyclophosphamid ist eine bekannte und nicht selten lebensbedrohliche Komplikation der Hochdosischemotherapie. Sie wird gehäuft nach allogener Knochenmarktransplantation beobachtet. Die hämorrhagisch-ulzerösen Veränderungen des Blasenurothels gehen ohne Prophylaxe mit Mikro-/Makrohämaturie, Koagelbildung und meist schwer stillbarer Blutung in bis zu 70 % der Patienten einher. Durch prophylaktische Maßnahmen läßt sich die Inzidenz reduzieren, jedoch nicht zuverlässig verhindern. Therapeutisch sind die meisten Fälle mit forcierter Diurese oder Dauerspülung der Blase unter Kontrolle zu bringen. Bei persistierender Blutung ist nach einem Stufenplan vorzugehen, der zunächst endoskopische Eingriffe und danach den Einsatz hämostyptischer Instillate vorsieht. Invasive Verfahren, wie Embolisation oder offen chirurgische Intervention bilden die Ausnahme, sind unter vitaler Indikation jedoch zu erwägen.
    Notes: Summary Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide. The incidence is particularly high after allogeneic bone marrow transplantation. The morphologic bladder wall changes are associated with gross hematuria, clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures. Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis. Treatment is initiated by forced diuresis and continous bladder irrigation. When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents. Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0584
    Keywords: Chronic myelogenous leukemia ; Allogeneic bone marrow transplantation ; Minimal residual disease ; BCR/ABL mRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A modified two-step polymerase chain reaction (PCR) was used for the amplification of BCR/ABL mRNA in 16 patients with Philadelphia chromosomepositive (Ph+) chronic myelogenous leukemia (CML) following allogeneic bone marrow transplantation (BMT). At different intervals after BMT, patient cells were assessed for the presence of BCR/ABL mRNA by two subsequent rounds of PCR amplification; this procedure increased the sensitivity for the detection of one Ph+ cell in 104–5 to one cell in 105–6. Eight of 16 patients were negative by two-step PCR 1–39 months after BMT, suggesting an elimination of Ph-positive cells or a decrease below the threshold of detection. Although five patients showed negative results by the one-step PCR only, they were tested positive when nested primers were used, indicating a substantial decrease in the amount of BCR/ABL target mRNA compared with earlier pre- or post-transplant analyses. One patient who was still PCR positive 27 months after BMT became negative 12 months later. Persistence of BCR/ABL mRNA-expressing cells correlated with subsequent clinical relapse only when the transplantation was performed during blast crisis. All patients who underwent transplantation in chronic phase, including those with BCR rearrangement by PCR, are in clinical and hematological remission between 24 and 95 months after BMT. We conclude that aggressive chemotherapy combined with total body irradiation is unable to completely eradicate the malignant clone in all CML patients, and it might be speculated that other mechanisms (e.g., graft versus host reaction [GVHD] or graft versus leukemia effect [GVL]) may effectively eliminate residual leukemic cells.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0584
    Keywords: Key words Aspergillosis ; Fungal infection ; Acute myeloid leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Systemic aspergillosis is a well-recognized complication of chemotherapy-induced neutropenia. In this report a patient with acute myeloid leukemia is described in whom a chronic aspergillosis with systemic involvement developed after recovery from neutropenia following intensive chemotherapy and allogeneic bone marrow transplantation. The clinical features of a chronic course of systemic aspergillosis suggest a distinct clinical entity comparable to chronic systemic candidiasis.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Within a few months we observed four patients withZieve's-Syndrome. All were young men with upper abdominal pain, vomiting, weith loss, and alcoholism. The laboratory data were correlated to the significant diagnostic criteria of liver disease, hemolysis, hyperlipemia, and spontaneous improvement after the patients obstained from alcohol. The results and the etiological problems are discussed.
    Notes: Zusammenfassung Innerhalb weniger Monate wurden in der poliklinischen Ambulanz vier Patienten mit einemZieve-Syndrom beobachtet. In allen Fällen handelte es sich um junge Männer mit Oberbauchbeschwerden, Erbrechen und Gewichtsverlust bei Alkoholabusus. Die Labordaten werden nach den entscheidenden diagnostischen Kriterien Leberschaden, Hämolyse, Hyperlipämie und Spontanbesserung nach Alkoholkarenz dargestellt. Die Ergebnisse werden diskutiert und die ätiologischen Probleme referiert.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Translocations involving chromosome band 11q23 are associated with acute lymphocytic and myelomonocytic leukemias with poor clinical prognosis. Pulsed-field gel electrophoresis (PFGE) was used to characterize the breakpoint region that has been mapped within a 300-kb fragment between the genes CD3G and PBGD. Using CD3G as a marker onSfuI-restricted DNA separated by PFGE, we detected a rearrangement involving 11q23 in the cell line B1 with a t(4; 11) and in the leukemic cells of two patients, one with a t(2; 11) and one with a t(11; 19). In comparison, lymphoblastoid cell lines established from normal peripheral blood lymphocytes of these two patients had a normal karyotype and showed germline configuration, thus excluding RFL polymorphisms. Digestion of DNA withBssHII orSalI showed heterogeneity of 11q23 involving breakpoints. A rearrangement in the t(4; 11) containing lymphoma cell line Karpas422 was seen only with the chromosome 4 probe KIT onSalI-digested DNA. PFGE is a reliable method for the mapping and detection of complex breakpoint regions. The break-points on 11q23 involve different introns of the highly spliced HRX/ALL-1/MLL gene.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0584
    Keywords: Key words Autologous bone marrow transplantation ; Autologous peripheral blood stem cell transplantation ; High-dose chemotherapy ; Second and secondary primary neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We treated 500 patients with high-dose chemotherapy (HDC) and autologous bone marrow (ABMT) or autologous peripheral blood stem cell transplantation (PBSCT). Treated conditions included leukemia, lymphomas, breast cancer, lung cancer, germ-cell carcinomas, and other solid tumors. In order to assess relapse of primary malignancy or occurrence of new neoplasms, routine screening after ABMT or PBPCT was performed at regular and close intervals. With a total follow-up of 1358 person-years and a median follow-up of 34 months (range 9–91), 10/500 (2%) patients developed second malignancies after PBSCT or ABMT; i.e., one new cancer occurred every 136 person-years. All malignancies were detected at routine follow-up examinations; and 7/10 diagnoses were made in an asymptomatic phase; 6/10 neoplasms were amenable to complete surgical resection, five of which remain in CR at a median of 23+ months after autotransplantation. We conclude that regular and close follow-up examination of patients after autologous hematopoietic stem cell transplantation may be beneficial, since successful treatment of second malignancies is possible in selected cases after early detection.
    Type of Medium: Electronic Resource
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