Nucleoside analog inhibitors
Biochemistry and Biotechnology
Wiley InterScience Backfile Collection 1832-2000
An ‘active analog’ approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV-1 reverse transcriptase. The preliminary results indicate that the O2, O4′, and O5′ atoms are capable of adopting a unique pharmacophoric pattern which may be the key to their recognition by reverse transcriptase.
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