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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  Evidenzbasierte Medizin - Anspruch und Wirklichkeit; 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft; 20040923-20040926; Berlin; DOC04dogP 067 /20040922/
    Publication Date: 2004-09-21
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG); 20060921-20060924; Berlin; DOC06dogP242 /20060918/
    Publication Date: 2006-09-19
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  26. Jahrestagung der Regionalgesellschaft der Augenärzte Sachsen-Anhalts und Thüringens; 20180831-20180901; Erfurt; DOC18sath21 /20180903/
    Publication Date: 2018-09-04
    Keywords: ddc: 610
    Language: German
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  • 4
    ISSN: 1432-1440
    Keywords: Diabetes Mellitus ; Autonome Neuropathie ; Autonome Funktionstests ; Renin ; Katecholamine ; Diabetes mellitus ; Autonomic neuropathy ; Autonomic function tests ; Renin ; Catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Quantitative assessment of signs or symptoms of neuropathy, and the beat-to-beat variation, valsalva, orthostasis, handgrip and cold pressor tests, and measurements of plasma renin and catecholamine excretion rate were performed in 23 diabetic patients and 10 age-matched normal subjects. Significant inverse correlations were found between the clinical score and the beat-to-beat variation (a test of efferent vagus function) (r=-0.72,P〈0.0005) or the pressor response to handgrip (possible test of efferent sympathetic integrity (r=-0.55,P〈0.005) or the values of both tests combined (r=-0.79,P«0.0005); but not with the other measured parameters. Beat-to-beat variation was abnormal in all 9 diabetics with increased and in 9 of 14 with normal clinical score, whereas only seven and one patient from these subgroups, respectively, had an abnormal Valsalva ratio. The pressor response to handgrip was only slightly reduced in the diabetic patients, with greater tendency in those with abnormal clincal score. Additional possible indices of adrenergic dysfunction such as the pressor response to cold stimulus, plasma renin levels and noradrenaline or adrenaline excretion rates did not differ significantly between normal subjects and diabetics. These findings demonstrate a greater prevalence of parasympathetic as compared to sympathetic impairment in diabetic autonomic neuropathy; the beat-to-beat variation was the most sensitive among the tests used. An assessment of clinical evidence combined with non-invasive functional procedures such as the beat-to-beat variation and handgrip tests provide a valuable and easy to perform tool in the evaluation of diabetic neuropathy.
    Notes: Zusammenfassung Bei 23 Diabetikern und 10 Normalpersonen wurden die klinischen Symptome und Befunde einer Neuropathie quantitativ analysiert, und der Beat-to-Beat-Variations-Test, der Valsalva-Versuch, die Orthostase-, Handdruck- und Kälte-Pressor-Tests sowie Bestimmungen von Plasmarenin und Katecholaminexkretionsraten durchgeführt. Die klinische Punktzahl korrelierte invers mit der Beat-to-Beat-Variation (Test der efferenten Vagusfunktion) (rΞ-0,72,P〈0,0005), mit der Blutdruckreaktion während manuellem Pressen (möglicher Test des efferenten Sympathicus) (r=-0,55,P〈0,005), sowie noch besser mit beiden Tests zusammen (r=-0,79,P«0,0005). Mit den übrigen Parametern korrelierte die klinische Punktzahl nicht. Die Beat-to-Beat-Variation war bei allen 9 Diabetikern mit erhöhter und bei 9 von 14 mit normaler klinischer Punktzahl abnormal, die Valsalva-Ratio bei 7 bzw. 1 Patient dieser Subgruppen. Die pressorische Antwort auf manuelles Pressen war bei den Diabetikern nur gering abgeschwächt, etwas ausgeprägter bei der Subgruppe mit erhöhter klinischer Punktzahl. Weitere mögliche Parameter der sympathischen Funktion wie Kälte-Pressoreffekt, Plasmarenin- und Urin-Adrenalin-und Noradrenalin-Werte unterschieden sich zwischen Normalpersonen und Diabetikern nicht signifikant. Diese Befunde weisen auf eine größere Prävalenz von parasympathischen gegenüber sympathischen Ausfällen bei autonomer diabetischer Neuropathie hin. Dabei war die Beat-to-Beat-Variation in dieser Serie der empfindlichste Test. Eine klinische Analyse kombiniert mit nicht-invasiven Funktionstests wie Beat-to-Beat-Variation und Handdruck-Test, sind nützliche und auch in der Praxis anwendbare Hilfsmittel bei der Untersuchung einer diabetischen Neuropathie.
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  • 5
    ISSN: 1432-1440
    Keywords: Orale Glukose-Belastung ; Insulin ; Kalium ; Renin ; Aldosteron ; Oral glucose-load ; Insulin ; Potassium ; Renin ; Aldosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The effects of a standard oral glucose load (100 g) on plasma glucose, insulin, potassium, renin and aldosterone levels were investigated in 10 supine normal subjects (Group A). Responses of plasma glucose, insulin, potassium and aldosterone to glucose ingestion were evaluated further in 16 seated normal or borderline hypertensive subjects (Group B), studied in the untreated state as well as following renin-aldosterone activation by diuretic pre-treatment. In both groups, the increase in plasma glucose and insulin following glucose ingestion was accompanied by an acute decrease (p〈0.01) in plasma potassium and aldosterone levels, which in Group A was associated with an increase (p〈0.02) in plasma renin activity. In all subjects analyzed together, significant (p〈0.005) correlations were noted between plasma aldosterone and potassium levels and between glucose-induced changes in these factors. In Group A, there were significant (p〈0.001) correlations between glucose-induced changes in plasma aldosterone and renin values and between absolute aldosterone and renin levels in the glucose-loaded state. Plasma aldosterone or renin levels following glucose-load were unrelated to glucose or insulin values. These findings indicate that an oral standard glucose load causes acutely marked aldosterone suppression and mild but distinct renin stimulation. The glucose-induced inhibition of aldosterone secretion appears to depend on insulin-mediated changes in potassium metabolism and may be partly counteracted by concomitant renin activation.
    Notes: Zusammenfassung Der Einfluß einer oralen Standard-Glukosebelastung (100 g) auf die Plasma-Konzentrationen von Glukose, Insulin, Kalium, Renin und Aldosteron wurde bei 10 liegenden Normalpersonen untersucht (Gruppe A). Das Verhalten der Plasma-Konzentrationen von Glukose, Insulin, Kalium und Aldosteron nach einer solchen Glukose-Einnahme wurde zudem bei 16 sitzenden, normalen oder grenzwertig-hypertensiven Personen studiert (Gruppe B), wobei die Untersuchungen im unbehandelten Zustand sowie nach Aktivierung des Renin-Aldosteron-Systems durch Vorbehandlung mit Diuretika erfolgten. In beiden Gruppen wurde der Anstieg der Plasma-Glukose und -Insulinwerte nach Glukose-einnahme von einer akuten Senkung (p〈0,01) der Plasma-Kalium und -Aldosteron-Konzentrationen begleitet. In Gruppe A fand sich gleichzeitig ein signifikanter Anstieg (p〈0,02) der Plasma-Renin-Aktivität. Die gemeinsame Analyse aller Personen ergab signifikante (p〈0,005) Korrelationen zwischen den basalen (prä-Glukose-Infusion) Absolutwerten von Plasma-Aldosteron und -Kalium einerseits und zwischen den Glukose-induzierten Änderungen dieser beiden Parameter andererseits. In Gruppe A fanden sich zudem nach der Glukose-Einnahme signifikante Beziehungen zwischen den absoluten Plasma-Aldosteron und-Reninwerten, sowie zwischen den Änderungen dieser beiden Parameter (p〈0,001). Dagegen korrelierten Plasma-Aldosteron- oder -Reninspiegel nicht signifikant mit den Glukose- oder Insulinwerten. Diese Befunde zeigen, daß eine orale Standard-Zufuhr von Glukose akut eine markante Aldosteron-Hemmung und eine leichte, aber signifikante Renin-Stimulation bewirkt. Die Glukose-induzierte Aldosteron-Suppression scheint mit den Insulin-vermittelten Änderungen des Kaliummetabolismus in Zusammenhang zu stehen und durch die Renin-Aktivierung teilweise antagonisiert zu werden.
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  • 6
    ISSN: 1573-2630
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The transparency of the lens of 485 eyes of 266 healthy volunteers were compared with 143 eyes of 83 diabetic patients. All the patients had well controlled diabetes. The transparency of the lens was measured with the opacity lensmeter 701. The concept of the instrument is based on the measurement of scattered light. The result revealed a similar transparency of the lenses of diabetic patients in relation to the normal volunteers. There was only a slight, and statistically not significant trend in the older age group versus a greater opacity for diabetic patients.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International ophthalmology 16 (1992), S. 1-5 
    ISSN: 1573-2630
    Keywords: lens light-scattering ; cataract ; Opacity Lens Meter 701 ; normal values
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Age-corrected normal values for the Opacity Lens Meter (OLM) 701 were established by measuring 1598 eyes of 799 healthy volunteers. This study revealed a remarkable age-relation for the normal values. The average readings of the OLM of the 30-year-old subjects were around 10 units whereas the average for the 65-year-olds was close to 20 units. The best fit of the opacity vs. age was a quadratic function. The interindividual variation was small in the young and quite large in the older population. The correlation between contralateral eyes was high (R=0.93).
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  • 8
    ISSN: 1573-2630
    Keywords: glaucoma ; visual field ; intraocular pressure ; visual acuity correlations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a retrospective study of 114 patients under treatment for chronic glaucoma (81 without and 33 with visual field defect) over an 11-year period of observation, a highly significant correlation between intraocular pressure and progression of visual field defects could be demonstrated. This correlation could be shown for the visual field outer boundary in 81 eyes with ocular hypertension and for typical visual field defects in 33 eyes with chronic glaucoma. The relationship was, however, only significant when both the standard deviation of the annual intraocular pressure and the influence of cataract development upon visual acuity were considered. Quantitative analysis of the results of Goldmann perimetry was by planimetry and took into account only changes during the 11-year observation period.
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  • 9
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Neben den charakteristischen Nervenfaserbündeldefekten eines Glaukoms sind bei okulärer Hypertension auch konzentrische Einengungen beschrieben worden. In dieser Retrospektivstudie wurde bei 81 Augen ohne lokale Gesichtsfelddefekte der Zusammenhang der Änderung der Isopterenlage und dem intraokularen Druck evaluiert. Es wurde ein statistisch signifikanter Zusammenhang zwischen der Änderung der Isopterenlage während den 11 Beobachtungsjahren und der Druckschwankung gefunden.
    Notes: Abstract The characteristic change in the glaucomatous visual field is a nerve fiber bundle defect. In addition, greater concentric constriction than in normal subjects is described. In this retrospective study a significant correlation was found between concentric constriction during the 11 years of observation and fluctuation of intraocular pressure during this time.
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  • 10
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is well known that perimetric findings fluctuate within a single examination. There is additional fluctuation between perimetric examinations. The cause of this fluctuation is not yet fully understood, but such things as changes in attention, patient cooperation, or drugs have been discussed. To study such possible factors, we carried out perimetry on subjects who had consumed alcohol and who had not. The results indicate that alcohol, at a blood concentration of approximately 0.08%, barely influences the results of static automated perimetry. Differential light sensitivity remained unchanged by alcohol at all eccentricities tested. A decrease in the ability to cooperate was manifested by a significant higher score of false-positives in catch trials. There was also a tendency toward an increase in false-negative responses in catch trials, an increase in the number of stimuli presentations required, and higher short-term fluctuation. Lack of the influence of alcohol on the differential light threshold does not necessarily mean that alcohol has no influence on visual function. It indicates, however, that differential light sensitivity, as measured with the automated perimeter Octopus, is not influenced by moderate alcohol ingestion.
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