Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1041
    Keywords: Bronchodilators ; methacholine ; healthy human subjects ; SDZ MKS 492 ; specific airway conductance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary An approximately steady-state reduction of specific airway conductance was induced in healthy human subjects by means of an individualized inhaled methacholine loading dose followed by a maintenance dose regime. Tested against this background bronchoconstriction, the xanthine analogue SDZ MKS 492, when administered as a single oral dose of 40 mg, showed a significant bronchodilator action, which lasted for up to 5.5 h. Bronchodilatation was not seen after administration of 10 or 20 mg doses. SDZ MKS 492 inhaled as a dry powder had a bronchodilator action that was small, most evident with the 12 mg dose and transient. The peak relief of imposed bronchoconstriction was 29% and the apparent half-time of removal of SDZ MKS 492 from its site of action was 5–6 min. Inhaled SDZ 492 had a bitter taste that was not masked by inclusion of menthol and aspartame in the formulation. The bronchodilatation seen in laboratory animals can also be produced by SDZ MKS 492 in man when administered orally or by inhalation. Its magnitude correlates better with the plasma concentration of parent drug than with that of either of the identified metabolites. Dispositional processes in the lung abbreviate its action after administration by inhalation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 30 (1990), S. 621-634 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The present research program, based upon the experimental performance of a 20 mm counter-rotating, non-intermeshing twin screw devolatilizer with several polymer/solvent systems has developed theoretical approaches to modeling both the bubble growth dominated mass transfer regime as well as the essentially bubble free regime (1, 2). This work encompasses the area of transition from the bubbling to the non-bubbling areas. This transition to some degree, probably exists in nearly all real devolatilization processes. The work combines a foam simulation model, which integrates elementary bubble processes, with the mass transfer from single phase liquid films through a penetration theory based model. The modeling is successful at correlating the experimental data and shows realistic effects with regard to residence time, surface area, and average mass transfer coefficient as functions of vent loading.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 30 (1990), S. 424-430 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A theoretical analysis of the diffusion-controlled, essentially bubble-free, mass transfer regime of polymer solution devolatilization has been performed for a counterrotating, nonintermeshing twin-screw extruder (1). The commonly used penetration diffusion approach is applied specifically to this geometry. Mass transfer from the recirculating pool and barrel film in the closed channel and the pool only in the open channel is taken into account. Use is made in this study of the recently determined pumping characteristics of this geometry (2), which allow the estimation of the length of the extraction section. Mass transfer rate measurements have been taken on a 20-mm extruder using the model system polystyrene/ethylbenzene. The agreement between the mass transfer calculations and the experimental results is very good.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-1920
    Keywords: Brain cysts ; Anomalies, congenital ; Magnetic resonance imaging ; Computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two cases of large asymptomatic cysts of the lateral ventricle are presented. The cyst walls or cyst contours were demonstrated well by proton density-weighted or T2-weighted spin echo images. These cysts are being detected as incidental findings in increasing frequency with the increasing use of MR imaging. Our data and review of the literature suggest that surgical intervention is not necessarily warranted, but that careful clinical evaluation is indicated. The diagnostic problem of intraventricular cysts is also discussed.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-1912
    Keywords: Adrenergic Receptors ; Frog Skin ; Sodium Transport ; Toad Bladder ; Water Permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of adrenergic nerve stimulation and catecholamines administered in vitro and in vivo on passive water and active and passive salt movement across epithelia have been reviewed. In general, where catecholamines affect these movements decreases are mediated by α- and increases by β-adrenoceptors. However, some species and considerable tissue differences in the responses which can be ellicited are evident. Thus: 1. α-Adrenoceptor activation antagonises drugs which increase water movement across amphibian skin and bladder without, in the latter, modifying the resting permeability. 2. In amphibian skins and in fish gills β-adrenoceptors mediate the increase in resting water flux caused by low concentrations of catecholamines. 3. β-Adrenoceptors mediate an increase in permeability with salt efflux and a stimulation of mucus secretion in amphibian skin. 4. α-Adrenoceptors mediate a reduction in Na+ movement across amphibian skin and fish gill respiratory epithelium; however adrenaline has little action on Na+ permeability of amphibian bladder. 5. β2-Adrenoceptors mediate the increased Na+ permeability caused by low concentrations of catecholamines. The localisation of the mechanisms responsible for these actions and their possible physiological significance is discussed.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 27 (1987), S. 1292-1299 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A novel high pressure polymer solution viscometer has been experimentally evaluated using the polystyrene/ethylbenzene system. The polymer solutions range in concentration from 60 weight percent polystyrene to the pure melt. The overall temperature range is 132°C to 240°C. The shear rates range from roughly 5 s-1 to 2000 s-1. It has been concluded that the present method is useful in determining the shear dependent behavior of these volatile solutions, The shear dependent nature of this system is consistent with accepted non-Newtonian viscosity theory.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: An experimental study of polymer soluticn devolatilization in a counterrotating twin-screw extruder has been undertaken. In an effort to ultimately predict mass transfer rates in such a process, this work analyzes the experimental results to determine the controlling mechanisms in the separation of volatile components from the polymer. The devolatilization process at hand encompasses the heavily foaming and nonfoaming regimes. Historically, the literature has centered primarily around the highly concentrated, bubble-free diffusion-controlled devolatilization regime. The analysis presented in this paper centers on the performance of the heavily foaming stages of the process. Recent and previously reported (1) data on the polystyrene/ethylbenzene (PS/EB) system, as well as newly collected data on the poly(methyl methacrylate)/methyl methacrylate (PMMA/MMA) system, are analyzed. In the foaming stages of the process, two regimes have been found. These regimes are differentiated by the availability of volume into which the foam can grow. Deformation and mixing effects appear to be secondary. Furthermore, temperature changes across the range of realistic operating conditions appear to affect mainly the thermodynamic driving force. It is only at extremely high temperatures that these effects are truly controlling.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...