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  • 1
    Keywords: Medicine ; Human Genetics ; Gene Expression ; Biomedicine ; Human Genetics ; Gene Expression ; Springer eBooks
    Description / Table of Contents: Identifying RNA Recombination Events and Non-covalent RNA-RNA Interactions with the Molecular Colony Technique -- RNA-directed Recombination of RNA in Vitro -- RNA-RNA Selex -- Identification of Antisense RNA S0tem-loops that Inhibit RNA-protein Interactions using a Bacterial Reporter System -- Trans-activation of Large Ribozymes -- Native Purification and Labeling of RNA for Single Molecule Fluorescence Studies -- Single Molecule Studies of RNA-RNA Interactions -- Modification Interference Analysis of the Ribosome -- Assessing Intermolecular RNA:RNA Interactions Within a Ribonucleoprotein Complex Using Heavy Metal Cleavage Mapping -- Monitoring RNA-RNA Interactions With Electrophoretic Mobility Shift Assays: Analysis Of Trna Binding To The T Box Riboswitch Antiterminator RNA -- Electrophoretic Mobility Shift Assay of RNA-RNA Complexes -- Structural Studies of a Double-stranded RNA from Trypanosome RNA Editing by Small Angle X-ray Scattering -- Fusion RNAs in Crystallographic Studies of Double-stranded RNA from Trypanosome RNA Editing
    Abstract: ℗ In this volume expert researchers in the field detail many of the methods which are now commonly used to study RNA. These methods are presented as a guidebook to scientists who are experienced with RNA research and want to brush up on a new technique. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, RNA-RNA Interactions: Methods and Protocols guides scientists investigating biological systems and studying RNA
    Pages: X, 219 p. 37 illus., 6 illus. in color. : online resource.
    ISBN: 9781493918966
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  • 2
    Keywords: Medicine ; Immunology ; Pathology ; Biomedicine ; Immunology ; Pathology ; Springer eBooks
    Description / Table of Contents: Pathology of Systemic Lupus Erythematosus - The Challenges Ahead -- The Lupus Biomarker Odyssey: One Experience -- Detection of Anti Nuclear Antibodies in SLE -- Tests for Circulating Immune Complexes -- Methods for Measuring Antibody Dependent Cell-Mediated Cytotoxicity in vitro -- Recombinant Antibody Microarray for Profiling the Serum Proteome of SLE -- Bi-functional Antibody Fragment-based Fusion Proteins for the Targeted Elimination of Pathogenic T-cell Subsets -- TLC Immunostaining for Detection of €œÁnti-Phospholipid́€ Antibodies -- Induced Murine Models of Systemic Lupus Erythematosus -- Measuring Interferon Alpha and other Cytokines in SLE -- Detection of SLE antigens in Neutrophils Extracellular Traps (NETs) -- Detection and Characterization of Autoantibodies Against Modified Self-proteins in SLE Sera after Exposure to Reactive Oxygen and Nitrogen Species -- Generation of Self-peptides to Treat Systemic Lupus Erythematosus -- Measurement of Malondialdehyde, Glutathione and Glutathione Peroxidase in SLE Patients -- Evaluating a Particular Circulating MicroRNA Species from an SLE Patient using Stem Loop qRT-PCR -- Microarray Technology for Analysis of MicroRNA Expression in Renal Biopsies of Lupus Nephritis Patients. Laboratory Tests for the Antiphospholipid Syndrome -- Isolation, Polarisation and Expansion of CD4+ T Helper Cell Lines and Clones using Magnetic Beads -- Meta-analysis as a Diagnostic Tool for Predicting Disease Onset and/or Activity in Systemic Lupus Erythematosus
    Abstract: Systemic Lupus Erythematosus: Methods and Protocols describes a number of genetic, biochemical and immunological techniques.℗ These techniques provide an℗ advancing understanding of the pathology, breakdown of the immune system, and therapeutic challenges of SLE in both humans and animal models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. ℗ Authoritative and practical, Systemic Lupus Erythematosus: Methods and Protocols℗ ℗ appeals to biomedical and clinical scientists in a number of pathology disciplines at the doctoral and post-doctoral level
    Pages: XVII, 263 p. 35 illus., 22 illus. in color. : online resource.
    ISBN: 9781493903269
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  • 3
    Call number: 05-MET-15:75
    Keywords: Nuclear magnetic resonance spectroscopy ; Nuclear Magnetic Resonance / methods
    Pages: xvii, 399 p. : ill.
    ISBN: 1560816651
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    05-MET-15:75 departmental collection or stack – please contact the library
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  • 4
    Call number: QV137:62 ; ZZ2003:4/Mag
    Keywords: Smoking / economics ; Smoking / prevention & control ; Smoking / legislation & jurisprudence ; Smoking Cessation / economics ; Health Policy ; DKFZ-publications
    Notes: This work was originally published by the World Bank in English as: Prabhat Jha, Frank J. Chaloupka. Curbing the epidemic : governments and the economics of tobacco control. This German translation was arranged by the German Cancer Research Center.
    Pages: xx, 138 p.
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    QV137:62 available
    ZZ2003:4/Mag departmental collection or stack – please contact the library
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  • 5
    Unknown
    London : Imperial College Press
    Associated volumes
    Call number: G183:2
    Keywords: Small interfering RNA ; Cancer ; MicroRNAs ; Gene Expression Regulation ; Neoplasms / genetics ; Neoplasms / therapy ; Tumor Markers, Biological
    Description / Table of Contents: Introduction to gene regulation by small RNAs -- The emerging non-coding RNA world -- MicroRNAs in C. elegans development -- MicroRNAs in mammalian development -- MicroRNAs in hematopoietic development -- MicroRNAs function as tumor suppressor genes and oncogenes -- Simultaneous detection of primary, precursor and mature microRNAs by qPCR -- Single nucleotide polymorphisms in microRNAs and microRNA binding sites with roles in cancer -- MicroRNAs as potential diagnostics and therapeutics -- MicroRNA target prediction -- Non-coding RNAs in cancer: the other part of the story
    Abstract: "MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer."--Back cover
    Pages: xv, 282 p. : ill. (some col.)
    ISBN: 9781848163669
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  • 6
    Call number: 01-Krebspraev:61
    Keywords: Smoking / economics ; Smoking / prevention & control ; Smoking / legislation & jurisprudence ; Smoking Cessation / economics ; Health Policy
    Pages: xii, 122 p. : ill.
    ISBN: 0821345192
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    01-Krebspraev:61 departmental collection or stack – please contact the library
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  • 7
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie; 75. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 97. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 52. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20111025-20111028; Berlin; DOCGR19-1135 /20111018/
    Publication Date: 2011-10-18
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 8
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    German Medical Science; Düsseldorf, Köln
    In:  Hypertonie 2004; 28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga; 20041124-20041127; Hannover; DOC04hochP27 /20050810/
    Publication Date: 2005-08-11
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 9
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    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  57. Kongress der Deutschen Gesellschaft für Handchirurgie; 20160922-20160924; Frankfurt am Main; DOC16dgh107 /20160920/
    Publication Date: 2016-09-20
    Keywords: Skaphoidfraktur ; Skaphoidpseudarthrose ; HCS-Schraube ; Kondylenplättchen ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 10
    Keywords: DISEASES ; GENE-EXPRESSION ; TRANSPORT ; MOTIF ; GAMMA ; ANNOTATION ; COMMON VARIANTS ; WIDE ASSOCIATION ; HAPMAP ; ENRICHMENT ANALYSIS
    Abstract: In the present study, an integrated hierarchical approach was applied to: (1) identify pathways associated with susceptibility to schizophrenia; (2) detect genes that may be potentially affected in these pathways since they contain an associated polymorphism; and (3) annotate the functional consequences of such single-nucleotide polymorphisms (SNPs) in the affected genes or their regulatory regions. The Global Test was applied to detect schizophrenia-associated pathways using discovery and replication datasets comprising 5,040 and 5,082 individuals of European ancestry, respectively. Information concerning functional gene-sets was retrieved from the Kyoto Encyclopedia of Genes and Genomes, Gene Ontology, and the Molecular Signatures Database. Fourteen of the gene-sets or pathways identified in the discovery dataset were confirmed in the replication dataset. These include functional processes involved in transcriptional regulation and gene expression, synapse organization, cell adhesion, and apoptosis. For two genes, i.e. CTCF and CACNB2, evidence for association with schizophrenia was available (at the gene-level) in both the discovery study and published data from the Psychiatric Genomics Consortium schizophrenia study. Furthermore, these genes mapped to four of the 14 presently identified pathways. Several of the SNPs assigned to CTCF and CACNB2 have potential functional consequences, and a gene in close proximity to CACNB2, i.e. ARL5B, was identified as a potential gene of interest. Application of the present hierarchical approach thus allowed: (1) identification of novel biological gene-sets or pathways with potential involvement in the etiology of schizophrenia, as well as replication of these findings in an independent cohort; (2) detection of genes of interest for future follow-up studies; and (3) the highlighting of novel genes in previously reported candidate regions for schizophrenia.
    Type of Publication: Journal article published
    PubMed ID: 24901509
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