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  • 1
    ISSN: 1432-1041
    Keywords: isosorbide dinitrate ; haemodialysis ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 10 patients with end stage renal disease on regular haemodialysis the plasma concentrations and dialyzer clearance of isosorbide dinitrate (ISDN) were determined after an oral dose of a retarded release formulation of 60 mg ISDN. The maximal plasma concentration of ISDN 2–7 h after oral administration was higher (14 ng/ml) than has been reported in healthy volunteers. The haemodialyzer clearance of ISDN was 92.4 ml/min at a blood flow of 200 ml/min and dialysate flow of 500 ml/min. During a 5-h haemodialysis an average of 0.3 mg ISDN was removed from the patient's circulation, representing about 0.5% of the administered dose and about 3% of the available drug in the circulation. No influence of haemodialysis on the plasma level of ISDN was found.
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  • 2
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 3
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A detailed report is given of a transfusion reaction of the hemorrhagichemolytic type due to the rare antibody anti-Cellano. The search for compatible blood for the patient-she had the blood group formula A1 ccD Ee KK-was further complicated by the development of a secondary antibody of the specificity anti-C (C major). This secondary antibody for a short time had the same titre (1: 512) as the anti-Cellano but showed both a different mode of reaction and a different stability. The necessity to use the optimal techniques for the serologic compatibility tests and to work only with fresh drawn blood samples when investigating sensitized patients is stressed. Among the therapeutical and organizational consequences the availability of samples of rare blood groups for the identification of irregular antibodies and of donors of this rare blood type is thought to be of special importance.
    Notes: Zusammenfassung Es wird ausführlich über einen hämolytischen, hämorrhagischen Transfusionszwischenfall berichtet, als dessen Ursache der seltene Antikörper Anti-Cellano diagnostiziert wurde. Die Suche nach kompatiblen Blutkonserven für die Patientin mit der Blutgruppenformel A1 ccD. Ee KK wurde noch kompliziert durch das nachträgliche Auftreten eines sekundären Antikörpers der Spezifität Anti-C (C-major) mit kurzfristig gleicher Titerhöhe (1: 512), aber unterschiedlicher Reaktionsweise und unterschiedlichem Stabilitätsverhalten. In der Reihe der therapeutischen und organisatorischen Konsequenzen wird neben der Forderung nach optimaler Technik der serologischen Verträglichkeitsprobe und für diese nach stets frischen Blutproben bei sensibilisierten Patienten die Notwendigkeit betont, seltene Blutmuster zur Identifizierung irregulärer Antikörper und entsprechende Blutspender dieser seltenen Formel verfügbar zu haben.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 43 (1981), S. 393-394 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 188 (1960), S. 498-499 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1. DISTRIBUTION OF ALKALINE PHOSPHATASE IN FRACTIONS H, M, T AND G Fraction A protein X s H 8 0-651 0- 0-220 (homogenate ) 7 030 0-662 0-015 M (medulla) T I 0-180 0-293 (tubular material ) G 0-030 (glomerula) This was achieved by pushing out the glomerula of the ...
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 947-948 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Several groups of research workers believe that the structural similarity of AMN and adenosine is indicative of a possible antagonistic action of AMN on adenosine -containing compounds which are essential for metabolism, such as ATP and pyridinenucleotides. Previous investigations have shown that ...
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Clinica Chimica Acta 149 (1985), S. 263-268 
    ISSN: 0009-8981
    Keywords: Acylcarnitines ; Carnitine ; Normal plasma values ; Radiochemical- enzymatic assay
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
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  • 8
    ISSN: 1618-2650
    Keywords: Best. von Eisen, Cobalt, Kupfer, Zink, Selen, Rubidium, Cäsium in Leber, Blutplasma, Erythrocyten, Normalbereiche, Neutronenaktivierungsanalyse, Gammaspektrometrie, Atomabsorptionsspektrometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Der Gehalt von Fe, Co, Cu, Zn, Se, Rb und Cs wurde in Blutplasma und in Erythrocyten von sechs Normalpersonen mittels der instrumentellen Neutronenaktivierungsanalyse und der flammenlosen Absorptionsspektrometrie (Cu) bestimmt. Zur Überprüfung der Richtigkeit wurde der NBS-Standard 1577, Ochsenleber, verwendet. Die erhaltenen Resultate für Elemente mit höheren Gehalten (Fe, Cu, Zn) liegen weitgehend im Bereich der bisher veröffentlichten Daten. Bei Elementen mit kleineren Gehalten (Co, Se, Rb, Cs) liegen unsere Werte in dem unteren Bereich oder darunter. Für diese Elemente wurden in Blutplasma und in Erythrocyten (hier bezogen auf Trockenmasse) die folgenden Mittelwerte ermittelt: Für Co 0,22 ±0,14 ng/ml, 0,59±0,23 ng/g, für Se 103±18 ng/ml, 401±29 ng/g, für Rb 167±36 ng/ml, 12,1±2,5 μg/g und für Cs 0,88±0,18 ng/ml, 13,0±5,7 ng/g.
    Notes: Summary The content of the above elements has been determined in blood plasma and in erythrocytes of six normal persons by instrumental neutron activation analysis and flameless atomic absorption spectrometry (Cu). The over-all accuracy of these techniques was checked by using the NBS standard 1577, Bovine Liver. The results obtained for elements of higher content (Fe, Cu, Zn) are essentially in the range of other published data. However, our results for elements occurring with lower contents (Co, Se, Rb, Cs) are in agreement with the lowest values of the published data and in some cases they are even significantly below these. For these elements, the following contents have been determined in blood plasma and in erythrocytes (here related to dry weight): for Co 0.22±0.14 ng/ml and 0.59±0.23 ng/g, for Se 103±18 ng/ml and 401±29 ng/g, for Rb 167 ±36 ng/ml and 12.1±2.5 μg/g and for Cs 0.88 ±0.18 ng/ml and 13.0±5.7 ng/g, respectively.
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  • 9
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Regression of osteitis fibrosa has been observed in a uremic patient after hemodialysis for six months. The exchangeable calcium was found to be 3.15 meq/kg and bone accretion rate 0.61 meq/kg/day in a control group of uremic patients without osteitis fibrosa under chronic hemodialysis. In contrast both values were markedly higher in the above patient with osteitis fibrosa and a control patient with osteitis (exchangeable calcium 10.3 meq/kg and 8.34 meq/kg; accretion rate 6.18 and 6.92 meq/kg/day). After hemodialysis for six months the exchangeable calcium of the patient decreased by 49.5% and his accretion rate by 35%. His intestinal absorption was high (60%) in contrast to uremic controls (35.5%). When measuring the regional distribution of47Ca in a body-counter the maximum of activity was found in the head-region in cases with osteitis fibrosa. This was shown to be due to rapid uptake of activity by the bones of the skull. Parathyroid hormone levels and serum hydroxyprolin were markedly increased, ultrafiltrable calcium was unchanged.
    Notes: Zusammenfassung Bei einem urämischen Patienten wurde die Rückbildung einer Ostitis fibrosa unter chronischer Hämodialyse beobachtet. Austauschbares Calcium (10,3 mÄq/kg bzw. 8,34 mÄq/kg) und Knocheneinbaurate (6,8 mÄq/kg/die bzw. 6,92 mÄq/kg/die) waren bei dem Patienten (und einem Kontrollpatienten mit renaler Ostitis fibrosa) deutlich erhöht. Nach Dialysebehandlung und Gabe von Aludrox verringerte sich das austauschbare Calcium um 49,5% und die Einbaurate um 35%. In einer Kontrollgruppe von Patienten mit terminaler Niereninsuffizienz unter Dauerdialyse wurde demgegenüber ein austauschbares Calcium 3,15 mÄq/kg und eine Knocheneinbaurate von 0,61 mÄq/kg gefunden. Das Maximum der im Ganzkörperprofil gefundenen Aktivitätsverteilung von47Ca — gemessen im Ganzkörperzähler — war bei den Patienten mit renaler Ostitis fibrosa kopfwärts verschoben; mit87mSr ließ sich die Anreicherung der Aktivität in den Schädelknochen nachweisen. Die Calcium-Absorption war bei dem Patienten (60%) deutlich höher als bei der urämischen Kontrollgruppe (35,5%). Die Serumparathormonspiegel und Serumhydroxyprolinspiegel waren bei renaler Ostitis fibrosa deutlich erhöht, das ultrafiltrable Calcium unverändert.
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  • 10
    ISSN: 1432-1440
    Keywords: Pharmacokinetics ; renal insufficiency ; cardiac glycosides ; methyl proscillaridin ; glycoside plasma concentrations ; Pharmakokinetik ; Niereninsuffizienz ; Herzglykoside ; Methylproscillaridin ; Glykosidplasmakonzentrationen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 8 Patienten mit Niereninsuffizienz unterschiedlichen Grades (CKreatinin: 0 bis 61,2 ml/min/1,73 m2 Körperoberfläche) und 6 gesunde Probanden erhielten eine einmalige Dosis von 0,75 mg Methylproscillaridin intravenös verabreicht. Die Glykosidplasmakonzentrationen wurden über einen Zeitraum von 58 Std mit einem86Rb-Erythrocyten-Assay gemessen. Die mittleren Eliminationshalbwertzeiten betrugen: 29,4±3,0 Std bei den Niereninsuffizienten und 27,3±4,3 Std bei den Gesunden. Die Eliminationskonstante des Methylproscillaridin zeigte eine schwache (r=0,33), insignifikante (P〉0,1) Korrelation zur CKreat. bei geringfügiger Änderung in einem Bereich von 0 bis 150 ml/min/1,73 m2. Für praktische Belange kann man davon ausgehen, daß die Halbwertzeit des Methylproscillaridin von der Nierenfunktion unabhängig ist.
    Notes: Summary Eight patients with renal insufficiency (creatinine clearance: 0 to 61.2 ml/min/1.73 m2) and six healthy subjects received a single dose of 0.75 mg of methyl proscillaridin intravenously. Glycoside plasma concentrations were measured for a period of 58 hours using a86Rb-erythrocyteassay. Mean half-life times were 29.4±3.0 hours for the patients with renal failure and 27.4±4.3 hours for the healthy subjects. The elimination constants showed some correlation (r=0.33,P〉0.1) creatinine clearance. The changes of the elimination constants were only small in the range from 0 to 150 ml/min/1.73 m2 for the creatinine clearance. For practical use half-life of methyl proscillaridin can be assumed independent of kidney function.
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