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  • 1
    Unknown
    Berlin, Heielberg : Springer
    Keywords: Medicine ; Toxicology ; Chemicals / Safety measures ; Medicine, Industrial ; Biomedicine ; Pharmacology/Toxicology ; Occupational Medicine/Industrial Medicine ; Biomedicine general ; Safety in Chemistry, Dangerous Goods ; Springer eBooks
    Description / Table of Contents: Foreword -- Introduction -- Operation mode of regulatory toxicology -- Aims and institutions -- Aims and mission -- Application areas -- National and international collaboration -- Procedures and standards -- The regulatory process -- Quality assurance in regulatory toxcicology -- Toxicological risk assessment -- Methodological repertoire -- Toxicological tests -- Characterization of physicochemical parameters -- Examination of acute and chronic toxicity -- Examination of organ-toxicity and of laboratory parameters -- Specific tests for neurotox , immunotox, allergy, irritation, reprotox and carcinogenicity -- Toxicity testing in vitro -- New and future toxicological assays -- Computer-based prediction models -- Metabolism tests -- Toxicokinetic tests -- Toxicodynamic tests -- Omics -- International regulation for toxicological test procedures -- Data acquisition in humans -- Epidemiological methods -- Studies in volunteers -- Chemical analysis in toxicology (New) -- Toxicostatistics and models -- Statistical evaluation methods -- Dose-response analysis, identification of threshold levels -- Extrapolation-procedures for carcinogenic and non-carcinogenic compounds -- Probabilistic methods -- Toxicodynamic models -- Toxicokinetic models -- Estimation of exposure -- Exposure analysis for indoor contaminants -- Exposure scenarios -- Use of toxiological data -- Quality criteria for primary literature -- Data-mining -- Paradigms use in risk evaluation -- Toxicological paradigms -- Do carcinogens have a threshold dose? pro and contra -- Single compounds vs combination effects -- Biomolecules vs smaller chemicals -- Sensitive humans vs average persons -- Assessment paradigmas -- Extrapolation factors and safety factors -- Background exposure vs additional exposure in human biomonitoring -- Adverse effects vs non-adverse effects -- ADI vs MOS principle -- Precaution principle vs hazard control -- Hygienic vs toxicological approaches -- Protected property and protection level -- Risk characterization and risk evaluation -- The risk concept -- Current℗ role of the term "risk" -- Risk cycles -- Risk minimization in drug development -- Data required for risk evaluation -- Importance of physical-chemical properties -- Importance of intrinsic toxic properties -- Importance of metabolism and of mechanism of action -- Importance of the extrapolation to lower doses in risk assessment -- Importance of exposure level for risk assessment -- Risk characterization -- Risk assessment -- Elements of risk assessment -- Risk comparison -- Risk-benefit considerations -- Risk assessment in different jurisdictions -- Reach as a regulatory instrument (New) -- Risk management and risk communication -- Risk management -- Purpose of risk management -- Assessment of limit values -- Deduction of limit values in different areas -- Registration and approval -- Classification and labelling -- Monitoring unwanted exposures and effects -- Restrictions and prohibitions -- Observance of susceptible population groups -- The toxicological expert report -- Risk management in toxicological emergencies -- Risk communication and participation of affected people -- Institutionalized participation -- The technique of risk communication -- Dealing with diseases that have been attributed to chemical exposures -- Addendum: tables and lists -- Checklist: Toxicological risk assessment in practice -- Glossary and risk terms -- Limit values, guideline values, tables -- Proposed additional chapters on℗ Ethics in toxicology and expansion of the chapter dealing with℗ Immunotoxicology
    Abstract: This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004.℗ Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference
    Pages: XXIV, 946 p. 144 illus., 70 illus. in color. eReference. : online resource.
    ISBN: 9783642353741
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  • 2
    Call number: Z070:250
    Pages: 414 p. : ill.
    Edition: 20., aktual. und erw. Aufl. 2010
    ISBN: 978-3-481-02614-1
    Signatur Availability
    Z070:250 departmental collection or stack – please contact the library
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  • 3
    Call number: 0112:2
    Keywords: Animals, Domestic / anatomy ; Anatomie / Atlas ; Haustier / Anatomie
    Pages: 265 p. : ill.
    ISBN: 3-432-29191-4
    Signatur Availability
    0112:2 departmental collection or stack – please contact the library
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  • 4
    Call number: 2020:98
    Keywords: Tier / Versuch
    Pages: 352 p. : ill.
    ISBN: 3-86025-195-3
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    2020:98 departmental collection or stack – please contact the library
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  • 5
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    Unknown
    Philadelphia, PA : Elsevier/Saunders
    Call number: QZ345:68(6)
    Keywords: Soft Tissue Neoplasms
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php)
    Pages: x, 1155 p. : ill.
    Edition: 6th ed.
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    QZ345:68(6) on loan
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  • 6
    Call number: YY Diss Dett/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 81 p.
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  • 7
    Call number: YY Diss Fran/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 54 p.
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  • 8
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    Unknown
    Heidelberg
    Call number: YY Diss Ober/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 105 p.
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  • 9
    Keywords: Toxicology ; Biochemistry ; Pharmacology/Toxicology ; Medical Biochemistry ; Pharmacotherapy ; Springer Nature Living Reference
    Abstract: DDrug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume ́€žSafety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: ́€žMethods in Clinical Pharmacology". For the 2nd℗ edition, all the existing chapters will be revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases etc. etc. The complete work was new arranged
    Pages: : online resource.
    ISBN: 9783319566375
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  • 10
    Unknown
    Bonn : Galileo Press
    (SAP press, 2864)  
    Call number: Z070:408
    Keywords: Management information systems
    Pages: 619 p. : ill.
    Edition: 4. Aufl.
    ISBN: 9783836228640
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    Z070:408 departmental collection or stack – please contact the library
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