Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    German Medical Science; Düsseldorf, Köln
    In:  21. Wissenschaftliche Jahrestagung der DGPP; 20040910-20040912; Freiburg/Breisgau; DOC04dgppP13 /20040909/
    Publication Date: 2004-09-09
    Description: Kongenitale Schwerhörigkeiten werden heute dank dem Neugeborenen-Hörscreening in den ersten Lebensmonaten entdeckt. Über 50% sind genetisch bedingt, davon sind 30% syndromal und 70% nicht-syndromal. Anomalien des Innenohres können damit vergesellschaftet sein.Vorgestellt wird der Fall eines 3-jährigen Jungen, bei dem mit 4 Monaten eine Gehörlosigkeit beidseits diagnostiziert wurde. Eine Rehabilitation mittels Hörgeräten und einer audiopädagogischen Förderung wurde eingeleitet. Im Verlauf eines Jahres reagierte der Junge weiterhin nicht auf akustische Reize, die Sprachentwicklung blieb aus. Im Rahmen der Vorabklärung für eine mögliche Cochlear Implantation zeigte sich in der radiologischen Untersuchung eine vollständige Felsenbeinaplasie beidseits. Um dem Kind eine Art akustischer Reizaufnahme zu ermöglichen, wurde eine vibrotaktile Hilfe angepasst. Die Seltenheit und die Folgen einer vollständigen beidseitigen Gehörlosigkeit bei Felsenbeinaplasie werden dargestellt und diskutiert.
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: CANCER ; CELLS ; EXPRESSION ; tumor ; CELL ; Germany ; MICROSCOPY ; THERAPY ; GENES ; PROTEIN ; cell line ; DIFFERENTIATION ; MOLECULAR CHARACTERIZATION ; MONOCLONAL-ANTIBODY ; TUMORS ; LINES ; PATIENT ; DOMAIN ; ANTIGEN ; ANTIGENS ; CONTRAST ; CELL-LINES ; BREAST ; breast cancer ; BREAST-CANCER ; antibodies ; antibody ; TARGET ; DELETION ; IDENTIFICATION ; immunohistochemistry ; MEMBRANE ; CELL-LINE ; LINE ; VACCINES ; LOCALIZATION ; CANCER-PATIENTS ; IMMUNITY ; IMMUNOTHERAPY ; CANCER PATIENTS ; mutagenesis ; cell lines ; ONCOLOGY ; RECOMBINANT ; LIBRARIES ; development ; LEVEL ; analysis ; NUCLEAR ; tumor antigen ; BREAST-TUMORS ; USA ; CANCERS ; SPECIMENS
    Abstract: Antibody-based cancer immunotherapy relies on the identification and characterization of target antigens and the development of potent antibodies recognizing the target. Here we report the expression analysis and molecular characterization of the differentiation antigen NY-BR-1, which we previously identified by using the SEREX (serological analysis of recombinant cDNA expression libraries) method. Corroborating methodologies, including mRNA quantitation and immunoblotting show that NY-BR-1 is strongly expressed in 〉70% of 129 breast tumors. Application of a NY-BR-1 specific antibody demonstrated NY-BR-1 expression in primary and metastastic breast cancers. In contrast, most of the breast cancer cell lines tested, expressed only low NY-BR-1 levels. Importantly, confocal microscopy revealed that ectopically expressed NY-BR-1 localizes to the cytoplasm and the cell membrane. NY-BR-1 localization in breast cancer specimens was also confirmed by immunohistochemistry. Bioinformatic analysis and deletion mutagenesis further show that NY-BR-1 membrane localization is mediated by 2 cis-active membrane targeting domains. Biochemical surface labeling and FACS analysis of live cells further characterize NY-BR-1 as a transmembrane protein, which can be specifically recognized by the anti-NY-BR-1 antibody on the surface of vital cells. The strong expression of NY-BR-1 in breast tumors, its cytoplasmic and membrane localization and accessibility to an ectopically applied antibody now suggest to pursue NY-BR-1 as a potential target for antibody-based therapies in breast cancer patients. (c) 2007 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 17330232
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: DISCOVERY ; IMMUNE-RESPONSES ; IMMUNE-RESPONSE ; IMMUNOTHERAPY ; immune response ; tumor ; CANCER ; DRUG ; ANTIGEN ; ANTIGENS ; RESPONSES ; immunology ; analysis ; humoral immune response ; response
    Type of Publication: Meeting abstract published
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    facet.materialart.
    Unknown
    German Medical Science; Düsseldorf, Köln
    In:  27. Deutscher Krebskongress; 20060322-20060326; Berlin; DOCOP058 /20060320/
    Publication Date: 2006-04-21
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1434-4483
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Summary An assessment is made of a regional climate model's skill in simulating the mean climatology and the interannual variability experienced in a specific region. To this end two ensembles comprising three realizations of month-long January and July simulations are undertaken with a limited are a operational NWP model. The modelling suite is driven at its lateral boundaries by analysed meteorological fields and the computational domain covers Europe and the North-western Atlantic with a horizontal resolution of 56 km. Validation is performed against both operational ECMWF analyses and objectively analysed precipitation fields from a network of ~ 1400 SYNOP rain gauge stations. Analysis of the simulated ensemble-mean climatology indicates that the model successfully reproduces both the winter and summer distributions of the primary dynamical and thermodynamical field, and also provides a reasonable representation of the measured precipitation over most of Europe. Typically the domain averaged model-biases are below 0.5 K for temperature and 0.1 g/kg for specific humidity. Analysis of the interannual variability reveals that the model captures the wintertime changes including that of the precipitation distribution, but in contrast the summertime precipitation totals for the individual years is not simulated satisfactorily and only partially reproduces the observed regional interannual variability. The latter shortcomings are related to the following factors. Firstly the model bias in the dynamical fields is somewhat larger for summer than winter, while at the same time summertime interannual variability is associated with weaker effects in the dynamical fields. Secondly the summertime precipitation distribution is more substantially affected by small-scale moist convection and surface hydrological processes. Together these two factors suggest that summertime precipitation over continental extratropical land masses might be intrinsically less predictable than wintertime synoptic scale precipitation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Summary  The precipitation forecasts of four operational numerical weather prediction models over the Alpine region are evaluated and intercompared for two periods of interest to the Mesoscale Alpine Programme (MAP). The new analysis of Alpine rainfall of Frei and Schaär (1998) is used to validate the models. It is found that the models have a tendency to overestimate the total precipitation and the frequency of intense rain events over high orography. The skill scores show good consistency between models, except for the ability to forecast light rain or heavy rain events. The partition between convective and stratiform rainfall is rather variable between the models.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...