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  • 1
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Australia Antigen ; Congenital Hepatitis ; Icterus Prolongatus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir haben 67 Neugeborene und 50 Säuglinge und Kleinkinder sowie 40 Mütter auf Australia-Antigen untersucht. Ein 8 Wochen altes Kind mit einer bioptisch verifizierten Hepatitis und die Mutter eines anderen Kindes waren Australia-Antigen-positiv. Ob die Untersuchung auf Australia-Antigen als Screening-Methode zur Erfassung diaplacentar mit Hepatitisvirus B infizierter oder an kongenitaler Hepatitis erkrankter junger Säuglinge brauchbar ist, werden erst weitere Untersuchungen an einer größeren Patientenzahl klären können.
    Notes: Abstract 67 newborn infants, 50 children up to the age of 36 months and 40 mothers were tested for the presence of Au.SH Antigen. One child of 8 weeks with hepatitis verified by biopsy and the mother of another child were Au/SH positive. It remains to be seen whether testing for Au/SH Antigen will prove useful as a screening method for diaplacental infection with Hepatitis Virus B or congenital hepatitis in newborn infants.
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  • 4
    ISSN: 1432-1076
    Keywords: Turner syndrome ; Growth ; Growth velocity ; Growth chart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spontaneous growth of 141 untreated girls with Turner syndrome was analysed. Of the patients 25% were born prematurely; their weight and height were normal when compared to prematurely born healthy infants. However, birth weight and height was significantly retarded in Turner patients born at term. A curve for height and growth velocity for the age range 0–16 years was constructed with a sensitive statistical method. By use of a mathematical model equations were created for calculating z-scores and the related percentiles for the height of individual patients at given age. median height of 18 untreated patients at 18 years was 143.8 cm. Analysis of growth velocity revealed a minor but significant growth spurt at the age of 12.5 years. This growth spurt was also detectable in patients without signs of spontaneous puberty and occurred later in patients with 45,X0 karyotype. Bone age progression was linear up to the age of 7.5 years and decelerated thereafter.
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  • 5
    ISSN: 1432-1076
    Keywords: Key words: Kallmann syndrome – X-recessive inheritance – Hypoplastic olfactory sulci – Rhinencephalon – MR-imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A 3-month-old infant presented with hypogonadism, a small penis and bilateral cryptorchidism. He showed an insufficient response of luteotropic hormone (LH) and follicle stimulating hormone (FSH) to luteotropic hormone releasing hormone (LHRH) and of testosterone to human chorionic gonadotrophin. The maternal uncle had hypogonadism and anosmia and also showed an impaired LH and FSH response to LHRH. MRI examination showed hypoplasia of the rhinencephalon in both cases. These findings in the son and brother of the clinically unaffected mother suggest X-linked recessive inheritance.
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  • 6
    ISSN: 1432-1076
    Keywords: Testosterone ; Estrogen ; LH ; Testicular size ; Development of the genitalia ; Puberty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Testesgröße, Genitalentwicklung und Reifezustand der Behaarung wurden bei 60 Knaben im Alter von 6 bis 15 Jahren mit der Harnausscheidung von LH, Östrogenen und von Testosteron verglichen. Eine Zunahme der Testesgröße sowie der Östrogenausscheidung konnte ab dem 9.–10. Lebensjahr, eine vermehrte Testosteronausscheidung ab dem 10.–11. Lebensjahr gemessen werden. Mit dem 11.–12. Lebensjahr setzt die Genitalentwicklung ein, und 1 Jahr später nimmt der Reifezustand der Behaarung zu. Ab diesem Zeitpunkt konnte auch mit unserer Methode eine vermehrte LH-Ausscheidung bestimmt werden.
    Notes: Abstract In 60 boys aged 6 to 15 years testicle size and the stages in the development of the genitalia as well as of pubic and axillary hair were correlated with the urinary excretion of LH, estrogens and testosterone. An increase in testicle size and in estrogen excretion was measured from 9 to 10 years onward, 1 year later testosterone excretion increases. At age 11 to 12 years development of the genitalia commences, followed 1 year later by that of pubic and axillary hair. From 12 to 13 years a real increase in LH excretion could be measured with our method.
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  • 7
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das tricho-rhino-phalangeale Syndrom (TRP) ist charakterisiert durch spärliches, langsam wachsendes Kopfhaar, eine große, “birnenförmige” Nase und Fingerdeformitäten; Minderwuchs kommt als fakultatives Symptom dazu. Durch die zapfenförmige Einstülpung der Epiphyse in die Diaphyse an Fingern und Zehen entsteht eine Klinodaktylie und Brachydaktylie. Die Physiognomie beim TRP ist so typisch, daß die Diagnose vermutet und durch Röntgenuntersuchungen leicht bestätigt werden kann. Bei einem 13jährigen Mädchen fand sich das Vollbild des Syndroms; mehrere Familienmitglieder zeigten nur Teilaspekte. Bei 9 Probanden wurden Hautleistenuntersuchungen durchgeführt.
    Notes: Abstract Sparse, slowly growing hair, a big pear-shaped nose and deformities of the fingers are the main characteristics of the tricho-rhino-phalangeal syndrome (TRP); dwarfism is a facultative sign. The cone shaped invagination of the epiphysis into the diaphysis of the fingers and toes causes clinodactyly and brachydactyly. The typical physiognomy of the TRP leads to the suspected diagnosis which may easily be confirmed by X-ray examination. In a 13-year-old girl the classical signs of a TRP were found; several members of the family demonstrated some features of the syndrome. Dermatoglyphic examinations were performed on 9 members of the family.
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  • 8
    ISSN: 1432-1076
    Keywords: Gonadotropins ; Infancy ; Pulsatile hormone secretion ; Puberty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In adults, luteinizing hormone (LH) and follicle stimulating hormone (FSH) are secreted in a pulsaltile manner. Prior to puberty gonadotropin (GN) levels are low and show only small fluctuations. The following investigation was performed to elucidate the type of GN secretion in infants: LH and FSH were determined every 30 min over a period of 8 h in three different groups: Group 1:2 male and 2 female adults; Group 2:2 male and 2 female prepubertal children; Group 3:3 male and 3 female infants, aged 6–12 weeks. Group 1 showed a clear pulsatile secretion of LH (4.5–23.5 mIU/ml [range]) and FSH (6.9–16.0 mIU/ml). Group 2 demonstrated a rather constant secretion of LH (〈1.5–2.3 mIU/ml) and FSH (1.6–4.9 mIU/ml). Group 3: In male infants pulsatile secretion of LH (3.6–34.7 mIU/ml)—and to a lesser degree of FSH (1.8–4.6 mIU/ml)—were found. In female infants the pulsatile secretion of FSH (6.5–22.7 mIU/ml) was more pronounced than that of LH (〈1.5–4.7 mIU/ml). The secretory pattern in early infancy is of a pulsatile type.
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  • 9
    ISSN: 1432-1076
    Keywords: Cystic fibrosis ; Growth ; Growth velocity ; Growth curve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The longitudinal growth in 139 patients with cystic fibrosis (CF) was investigated from birth until the age of 19 years. Already at birth weight and length were reduced (weight: −0.83±0.13 SDS in girls, −0.44±0.13 SDS in boys; length: −0.55±0.13 SDS in girls, −0.39 ±0.14 SDS in boys; mean ± SEM). Both variables showed a further decline until diagnosis was established (weight: −1.57±0.21 SDS in girls, −1.46±0.25 SDS in boys; length: −1.15±0.32 SDS in girls, −1.03 ±0.52 SDS in boys; mean ± SEM). Six to 12 months after diagnosis length improved and reached the 25th percentile in both sexes. Height and weight followed the 25th percentile throughout childhood. Growth velocity was fairly normal during this period. There was a loss in percentiles of both height and weight after the age of 8 years and the pubertal growth spurt was delayed and reduced. However, the 25th percentile was reached again in the adolescent period. At the age of 19 years median height was 161,5 cm in girls and 173 cm in boys, both representing the 25th percentile. Using a sensitive statistical method for analysis of growth data we present CF specific growth curves for height, weight and growth velocity. There was no significant effect of pulmonary colonization withPseudomonas aeroginosa on growth velocity.
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  • 10
    ISSN: 1432-1076
    Keywords: Key words: Cystic fibrosis – Growth – Growth velocity – Growth curve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The longitudinal growth in 139 patients with cystic fibrosis (CF) was investigated from birth until the age of 19 years. Already at birth weight and length were reduced (weight: −0.83±0.13 SDS in girls, −0.44±0.13 SDS in boys; length: −0.55±0.13 SDS in girls, −0.39±0.14 SDS in boys; mean±SEM). Both variables showed a further decline until diagnosis was established (weight: −1.57±0.21 SDS in girls, −1.46±0.25 SDS in boys; length: −1.15±0.32 SDS in girls, −1.03±0.52 SDS in boys; mean±SEM). Six to 12 months after diagnosis length improved and reached the 25th percentile in both sexes. Height and weight followed the 25th percentile throughout childhood. Growth velocity was fairly normal during this period. There was a loss in percentiles of both height and weight after the age of 8 years and the pubertal growth spurt was delayed and reduced. However, the 25th percentile was reached again in the adolescent period. At the age of 19 years median height was 161.5 cm in girls and 173 cm in boys, both representing the 25th percentile. Using a sensitive statistical method for analysis of growth data we present CF specific growth curves for height, weight and growth velocity. There was no significant effect of pulmonary colonization with Pseudomonas aeruginosa on growth velocity.
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