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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi); 20110926-20110929; Mainz; DOC11gmds500 /20110920/
    Publication Date: 2011-09-20
    Keywords: Kosten-Analyse ; Forschung ; Verwertung ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi); 20110926-20110929; Mainz; DOC11gmds005 /20110920/
    Publication Date: 2011-09-20
    Keywords: Kosten-Nutzen-Analyse ; Output ; Systematisierung ; IT-Projekte ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  126. Kongress der Deutschen Gesellschaft für Chirurgie; 20090428-20090501; München; DOC09dgch11099 /20090423/
    Publication Date: 2009-05-06
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMDS 2012; 57. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 20120916-20120920; Braunschweig; DOC12gmds020 /20120913/
    Publication Date: 2012-09-14
    Keywords: Wirtschaftlichkeit Gesundheitsprojekt ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Sophorolipids, obtained by a two-stage process starting from deproteinized whey concentrate using Cryptococcus curvatus ATCC 20509 and Candida bombicola ATCC 22214, were compared to products from one-stage processes, using different lipidic compounds as substrates. Results showed that above all carbon source and not cultivation conditions had a distinct influence on the composition of the crude product mixture and therefore on the physicochemical and biological properties of the sophorolipids, such as, for example, surface activity, cytotoxicity and stability against hydrolases. The results were completed by corresponding data for purified mono- and diacetylated (17-hydroxyoctadecenoic)-1′,4′′-lactonized sophorolipids. Crude sophorolipid mixtures showed moderate to good surface active properties (SFTmin 39 mN m−1, CMC 130 mg l−1), water solubilities (2–3 g l−1) and low cytotoxicities (LC50 300–700 mg l−1). In contrast, purified sophorolipids were more surface active (SFTmin 36 mN m−1, CMC 10 mg l−1), less water soluble (max. 70 mg l−1) and showed stronger cytotoxic effects (LC50 15 mg l−1). Incubation of crude sophorolipid mixtures with different hydrolases demonstrated that treatment with commercially available lipases such as from Candida rugosa and Mucor miehei distinctly reduced the surface active properties of the sophorolipids, while treatment with porcine liver esterase and glycosidases had no effect.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Vertebrate skin fulfils its protective function mainly in two different ways:(1) the epithelium forms an extremely resistant layer of horny structures (scales, hair, etc.) which are permanently replaced by means of cellular proliferation and maturation;(2) skin has a remarkable ability to respond quickly to all kinds at attack from the environment by an acceleration of cellular proliferation in the epidermis (which leads to a closure of wounds or a thickening of the protective layer) and by a stimulation of other defense mechanisms such as the recruitment of white blood cells as a constituent of inflammatory reactions.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary From the latex of Euphorbia tirucalli L. growing in Madagascar, 5 new euphorbia factors were isolated. They were characterized as 13-O-acetyl-12-O-acylphorbol-and 12-O-acetyl-13-O-acylphorbol derivatives carrying homologous conjugated unsaturated fatty acids as acyl groups. Furthermore, 2 mixtures of homologous 3-O-acylingenol derivatives are obtained carrying the same type of unsaturated fatty acids. Due to their highly unsaturated acyl groups all Euphorbia factors or factor groups isolated are highly sensitive to autoxidation.
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 115 (1986), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1262
    Keywords: Key words Cyclo-oxygenase ; Colon carcinogenesis ; Crohn’s disease ; Familiar adenomatous polyposis coli ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Deregulation of cyclo-oxygenase isozyme expression has been shown to be a consistent feature of inflammatory bowel diseases and colorectal cancer in humans. This study investigated the cellular localization of aberrant cyclo-oxygenase expression in normal and diseased colon. Biopsies of seven normal colonic tissues, eight tissue samples from patients suffering from Crohn’s disease, five polyps from patients with familiar adenomatous polyposis coli, and ten sporadic adenocarcinomas were analyzed using isozyme-selective immunoprecipitation, western blotting, and immunohistochemistry. Cyclo-oxygenase-1 expression was demonstrated in normal human colon, Crohn’s disease, and colorectal tumors. In normal colon and also in adenomatous polyps, cyclo-oxygenase-1 specific immunosignals were localized to epithelial cells of the upper part of the crypts and endocrine cells of the lower part. In Crohn’s disease cyclo-oxygenase-1 expression was restricted to cells of the inflammatory infiltrate. While barely detectable in normal colon, cyclo-oxygenase-2 protein was strongly increased in epithelial cells located in the uppermost part of the crypts, in surface epithelial cells, and in mononuclear cells of the lamina propria of Crohn’s disease. The constitutive overexpression of cyclo-oxygenase-2 protein observed in the majority of the adenomatous polyps and all adenocarcinomas was attributed to both epithelial and interstitial cells in that the latter predominated in adenomas, and epithelial cells were the prevailing cyclo-oxygenase-2 expressing cell type in adenocarcinomas. In conclusion, both autocrine and paracrine effects of aberrant cyclo-oxygenase-2 expression may contribute to the development of Crohn’s disease and colonic tumor development.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1335
    Keywords: Diterpene esters ; Irritant activity ; Structure-Activity relationships ; Tumor promoting activity ; Diterpenester ; irritierende Aktivität ; Strukturwirkungs-beziehungen ; tumorpromovierende Aktivität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Kinetik der irritierenden Wirkung von einigen polyfunktionellen Diterpenestern auf dem Mausohr [Erythem-Auslösung, quantitativ gemessen als irritierende Dosis 50 (ID50)], und ihre Beziehung zur initiationspromovierenden Aktivität auf der Rückenhaut der NMRI-Maus wurde untersucht: 1) Ein sehr schnell einsetzendes, aber rasch abklingendes Erythem ist mit schwacher oder fehlender Promoter-Wirkung verbunden. 2) Ester, die ein schnell einsetzendes, aber langsam abklingendes Erythem verurschen, zeigen in den meisten Fällen mäßige bis starke initiationspromovierende Wirkung und 3) relativ spät einsetzende, aber anhaltende Erythem-Wirkung (bis mindestens 24 h) ist mit hoher promovierender Aktivität verbunden. Diese Ergebnisse weisen auf eine Beziehung zwischen der Kinetik der irritierenden Wirkung und der initiationspromovierenden Aktivität der Diterpenester hin. Die verhältnismäßig geringe promovierende Aktivität von Estern mit mehrfach ungesättigten Acylresten könnte auf den Einfluß von pharmakologischen Parametern wie Bioverfügbarkeit und Stabilität im biologischen System, Wirkstoff-Rezeptor-Wechselwirkung und “intrinsic activity” der Diterpeneser hinweisen.
    Notes: Summary The kinetics of the irritant response on the mouse ear [erythema measured quantitatively by the irritant dose 50 (ID50)] and its relation to the initiation-promoting activity on the back skin of NMRI mice of some polyfunctional diterpene esters were investigated: (1) A very rapid and transient erythema response is associated with low or absent promoting activity (2) an early and more persistent erythema response in most cases is associated with moderate-to-high promoting activity, and (3) a relatively late onset but persistence up to at least 24 h of the erythema response is associated with high promoting activity. These results may indicate a relationship between the kinetics of the erythema response and the initiation-promoting activity of diterpene esters. The comparatively low promoting activity of esters carrying polyunsaturated acyl functions may indicate that importance of pharmacological parameters such as biovailability and stability in the biological system, drug-receptor interaction, and “intrinsic activity” of the diterpene esters.
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