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  • 1
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    Cheltenham, U.K ; Northampton, Mass : Edward Elgar
    Keywords: European Union countries, Appropriations and expenditures ; Electronic books ; Finance, Public, Auditing, European Union countries ; Fiscal policy, European Union countries
    Pages: xvi, 256 p.
    ISBN: 1-8454-2560-X
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  • 2
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    CHICAGO U. A.: YEAR BOOK MEDICAL PUBL.
    Call number: WN1Z:26/9,1
    Keywords: GELENK / RADIOGRAPHIE
    Pages: 37 S., 16 ABB.
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  • 3
    Keywords: Life sciences ; Plant anatomy ; Plant development ; Plant Pathology ; Plant physiology ; Plant breeding ; Life sciences ; Plant Genetics and Genomics ; Plant Breeding/Biotechnology ; Plant physiology ; Plant Systematics/Taxonomy/Biogeography ; Plant Anatomy/Development ; Plant Pathology ; Springer eBooks
    Description / Table of Contents: Introduction -- Cultivation and uses of cucurbits -- Evolution and phylogeny of the cucurbits -- Genetic Resources of Melon -- Genetic resources of cucumber -- Genetic resources of watermelon -- Genetic resources of Cucurbita spp -- Genetic resources for minor cucurbit crops -- Genetic mapping of complex traits in cucurbits (populations, genetic maps and traits) -- The melon genome -- The cucumber genome -- The watermelon genome -- Cucurbita genome(s) -- The genome of minor cucurbit crops -- Comparative genomics of the Cucurbitaceae -- Organellar genomes of the cucurbits -- Databases and bioinformatics for cucurbit species -- Cucurbit mutants and tilling populations -- Genetic transformation of cucurbit species -- VIGS and functional analyses -- Phloem -- Grafting -- Floral sex expression -- Fruit growth and development -- Fruit quality -- Genomic/transcriptomic analysis -- Sugar and organic acids -- Aroma -- Color -- Fruit ripening -- Disease resistance -- Phytochemistry -- Abiotic stress -- Bridging classical and genomic approaches to cucurbit breeding -- Opportunities for genomic applications to cucurbit breeding
    Abstract: This book provides an overview of the current state of knowledge of the genetics and genomics of the agriculturally important Cucurbitaceae plant family, which includes crops such as watermelon, melon, cucumber, summer and winter squashes, pumpkins, and gourds. Recent years have resulted in tremendous increases in our knowledge of these species due to large scale genomic and transcriptomic studies and production of draft genomes for the four major species,℗ Citrullus lanatus,℗ Cucumis melo,℗ Cucumis sativus, andCucurbita spp. This text examines genetic resources and structural and functional genomics for each species group and across species groups. In addition, it explores genomic-informed understanding and commonalities in cucurbit biology with respect to vegetative growth, floral development and sex expression, fruit growth and development, and important fruit quality traits
    Pages: XIII, 430 p. 61 illus. in color. : online resource.
    ISBN: 9783319493329
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  • 4
    Keywords: Medicine ; Pharmaceutical technology ; Biochemistry ; Animal Physiology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Animal Biochemistry ; Animal Physiology ; Springer eBooks
    Description / Table of Contents: Anticancer Potential of Spider Venom -- Antimicrobial Peptides in Spider Venoms. - Antimicrobial, Insecticides, Analgesics, and Hyalurodinases from the Venom Glands of Brachypelma Spiders -- Bioecology of Spiders with Emphasis in Spiders of Public Health Importance -- Hippasa Spider, Biology, Envenomation, Toxin Profiles, Biological Functions: A Review. - Identifying Insect Protein Receptors Using an Insecticidal Spider Toxin -- In Silico Modeling of Spider Toxins: Bioinformatics, Molecular Docking, and Molecular Dynamics -- Loxosceles and Loxoscelism: Biology, Venom, Envenomation and Treatment -- Pain-Modulating Peptides in Spider Venoms: Good and Evil -- Peptidom and Transcriptom Analysis of the Toxin-Like Peptides in the Venom Glands of Tarantula Grammostola Rosea. - Phoneutria nigriventer Venom and Toxins: A Review -- Phoneutria nigriventer Venom: Action in the Central Nervous System. - Recent Insights in Latrodectus ("Black Widow" Spider) Envenomation: Toxins and Their Mechanisms of Action -- Spider Transcriptomes from Venom Glands: Molecular Diversity of Ion Channel Toxins and Antimicrobial Peptide Transcripts -- Spider Venom and Drug Discovery: A Review. - Structural Diversity and Basic/Acidic Residue Balance of Active Cysteine-Rich Insecticidal Peptides from Spiders -- Studying the Excitatory and Inhibitory Neurotransmissions with Spider Venoms. - The Non-peptide Low Molecular Mass Toxins from Spider Venoms -- The Venom from Lasiodora sp.: A Mygalomorph Brazilian Spider -- The Venom of Australian Spiders -- Venom of Cupiennius salei (Ctenidae)
    Abstract: This volume provides an overview of the biochemical characterization, structure-function studies, proteomics, bioinformatics, molecular biology, transcriptomics and genomics of various spider species. The book also covers our current knowledge of venom components, toxins and their modes of action. The first section of Spider Venom includes contributions regarding the wide diversity of spider venom components and depicts some of their biological effects (antimicrobial, ion channel modulators, insecticides, this includes peptide and non-peptide toxins), and emphasizes spiders of public health importance. The second section covers transcriptomes, proteomes (and peptidomics), bioinformatics and molecular dynamics. The last section describes antimicrobial, insecticidal toxins, envenomation and the medical potential of spider venoms. Spider venoms are a great and extensive source of bioactive compounds, and as such form a boundless and bountiful area awaiting discovery. It is by virtue of dedicated scientists that new toxins are discovered and that new insights arise, leading the way towards the investigation of their pharmacological effects, and hopefully, as a consequence, arriving at the discovery of venom components as new drug candidates
    Pages: 552 illus., 165 illus. in color. eReference. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9789400763890
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  • 5
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    New York, NY : Springer New York
    Keywords: Medicine ; Molecular Biology ; Biomedicine ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Applications of Molecular Genetics to the Study of Asthma -- Assessment and Validation of New Genetic Variants: A systematic In Silico Approach -- Introduction to the Gene Expression Analysis -- Real Time PCR for Gene Expression Quantification in Asthma -- Validation of Reference Genes in mRNA Expression Analysis Applied to the Study of Asthma -- Review of Methods to Study Gene Expression Regulation Applied to Asthma -- Interactions of DNA and Proteins: Electrophoretic Mobility Shift Assay in Asthma -- SDS-Polyacrylamide Electrophoresis and Western Blotting Applied to the Study of Asthma -- Chromatin Immunoprecipitation: Application to the Study of Asthma -- Gene Silencing Delivery Methods: Lipid-Mediated and Electroporation Transfection Protocols -- Protocols for Exosome Isolation and RNA Profiling -- Cell Culture Techniques: Corticosteroid Treatment in A549 Human Lung Epithelial Cell -- Protocol for Lipid-Mediated Transient Transfection in A549 Epithelial Lung Cell Line -- Promoter Assay Using Luciferase Reporter Gene in the A549 Cell Line -- Review of Mouse Models Applied to the Study of Asthma -- General and Specific Mouse Models for Asthma Research -- Mouse Models applied to the Research of Pharmacological Treatments in Asthma -- Review on Pharmacogenetics and Pharmacogenomics Applied to the Study of Asthma
    Abstract: Presenting topics from the basic application of molecular genetics to more complex gene expression analysis using different models of study, this detailed volume explores asthma through the lens of genetics, considered to play an essential role in the etiopathogenesis of the disease. Since asthma is a complex disease, this book is designed to provide a review of the most useful techniques with examples of their applications in specific laboratory protocols. Written in the highly successfulMethods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Molecular Genetics of Asthma serves as an ideal guide to researchers investigating this vital field of study
    Pages: XV, 275 p. 43 illus., 38 illus. in color. : online resource.
    ISBN: 9781493936526
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  • 6
    Keywords: Medicine ; Medical records / Data processing ; Medicine & Public Health ; Health Promotion and Disease Prevention ; Health Economics ; Health Informatics ; Medicine/Public Health, general ; Springer eBooks
    Description / Table of Contents: Introduction -- Incentives for innovation: a survey -- Incentives for innovation: neglected diseases -- When patents are not enough: supplementary incentives for pharmaceutical innovation -- The Contribution of the United States, Europe and Japan in Discovering New Drugs: 1982 2003 -- The use of pay for performance for drugs: can it improve incentives for innovation? -- Drug Price Regulation: Recent Trends and Downstream Neglected Issues
    Abstract: 〈p〉Incentives for innovation are particularly relevant in the pharmaceutical〈/p〉〈p〉industry where not all social needs provide equally profitable〈/p〉〈p〉opportunities and where most OECD countries try to implement diffe -〈/p〉〈p〉rent measures that promote research in these less profitable areas. The〈/p〉〈p〉lack of incentives for innovation is especially dramatic when we take〈/p〉〈p〉into account diseases affecting mostly low-income countries, and also〈/p〉〈p〉diseases affecting small groups of patients.〈/p〉〈p〉How can incentives be provided to deal with these less profitable acti -〈/p〉〈p〉vities when no clear markets exist for the innovations being introduced?〈/p〉〈p〉Some of the contributions of this book go into discussing alternative〈/p〉〈p〉mechanisms to substitute for these inexistent markets, and〈/p〉〈p〉situations where traditional instruments such as public procurement or〈/p〉〈p〉direct subsidies have proven totally insufficient. Also, this book discusses〈/p〉〈p〉the clear mismatch between the size of the markets being targeted and〈/p〉〈p〉the incentives being provided.〈/p〉〈p〉
    Pages: IX, 96 p. : digital.
    ISBN: 9788493806279
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  • 7
    Keywords: Medicine ; Geriatrics ; Aging / Research ; Science / Study and teaching ; Biomedicine general ; Geriatrics/Gerontology ; Aging ; Science Education ; Science, Humanities and Social Sciences, multidisciplinary ; Springer eBooks
    Description / Table of Contents: Preface -- The Need for Differentiated Research Methodology in Aging -- The Scientific Method as a Point of Departure in Aging Research -- Biomedical Research in Aging -- Geroscience -- Descriptive Studies in Clinical Gerontology and Geriatrics -- Qualitative Research in Gerontology and Geriatrics -- Case-control Studies in Aging Research -- Longitudinal Studies and Older Adults Cohorts -- Clinical Trials in Aging Research -- Mixed Methods in Geriatrics and Gerontology Research -- Systematic Reviews and Meta-analysis in Aging Research -- Health Systems Research in Aging -- Technology and Aging: Ubiquitous Sensing Technology for Aging Research -- The Challenge of Big Data and Data Mining in Aging Research -- Research in Public Policies for Aging -- Ethical Issues in Research in Aging -- Integration of Consortiums and Search for International Funding -- Future of Aging Research -- Index
    Abstract: This is the second edition of a well received book that reviews classical epidemiological and clinical research designs, with a specific focus on aging. Chapters cover basic topics like the scientific method, ethics, and the consequences of certain exclusion criteria. The work also includes a look at clinical concepts like multimorbidity, frailty and functionality. New material includes chapters such as geroscience, health systems research, big data and data mining, financing and future of aging research. The authors reveal the issues and challenges for researchers of age and aging, and also consider, from basic to clinical, and from clinical to public policies of social and health care. The focus on aging is what gives this book its valuable perspective on research methodology. All authors have considerable experience in aging, geriatrics or gerontology, and each chapter includes both a theoretical framework and practical examples of studies in aging. Readers will discover study designs that are reviewed for basic structure, main flaws and advantages, and are analyzed for specific conditions and variables regarding aging. This text is suited to both health care professionals caring for older adults, and researchers who are new to research in aging. It is relevant across the disciplines, including medicine, psychology, social sciences and dentistry, and it supports learning with graphs and figures
    Pages: XII, 246 p. 17 illus., 7 illus. in color. : online resource.
    Edition: 2nd ed. 2018.
    ISBN: 9783319953878
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  • 8
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    New York, NY : Springer Science+Business Media, LLC
    Keywords: Medicine ; Interventional radiology ; Cardiology ; Gastroenterology ; Clinical Medicine ; Transplantation of organs, tissues, etc ; Medicine & Public Health ; Hepatology ; Gastroenterology ; Cardiology ; Transplant Surgery ; Interventional radiology ; Springer eBooks
    Pages: : digital
    ISBN: 9781441983275
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  • 9
    Keywords: Medicine ; Critical care medicine ; Cardiology ; Medicine & Public Health ; Cardiology ; Intensive / Critical Care Medicine ; Springer eBooks
    Pages: : digital
    ISBN: 9780387874296
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  • 10
    Keywords: Medicine ; Oncology ; Cancer / Surgery ; Pathology ; Surgery ; Medicine & Public Health ; Oncology ; Surgical Oncology ; Pathology ; Surgery ; Springer eBooks
    Pages: : digital.
    Edition: 2nd ed.
    ISBN: 9781461420804
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