Springer Online Journal Archives 1860-2000
Process Engineering, Biotechnology, Nutrition Technology
Abstract The expression of interferon (IFN)-β gene was studied in mouse peritoneal macrophages (PM) harvested from normal mice (lps n ) or LPS-hyporesponsive mice (lps d ). A strong direct correlation between the LPS response of PM and their capacity to expressing basal levels of IFN was found. The results suggest that the constitutive expression of IFN-β gene can play an important role not only in the resistance to viral infection but also in the modulation of cell differentiation.
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