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  • 1
    Call number: QZ241:3(2)/20,2
    Keywords: Liver / Tumors ; Liver Neoplasms / classification ; Liver Neoplasms / pathology
    Notes: Rev. ed. of: Histological typing of tumours of the liver, biliary tract, and pancreas. 1978.
    Pages: x, 125 p. : ill. (some col.)
    Edition: 2nd ed.
    ISBN: 3540581545
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    QZ241:3(2)/20,2 available
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  • 2
    Call number: QZ241:3(2)/20,1
    Keywords: Gallbladder / Tumors ; Bile ducts / Tumors ; Gallbladder / Tumors ; Bile duct / Tumors ; Bile Duct Neoplasms / classification ; Bile Duct Neoplasms / pathology ; Gallbladder Neoplasms / pathology ; Gallbladder Neoplasms / classification
    Notes: Rev. ed. of: Histological typing of tumours of the liver, biliary tract, and pancreas / J.B. Gibson, in collaboration with L.H. Sobin and pathologists in 13 countries. 1978. (International histological classification of tumours ; no. 20)
    Pages: x, 75 p. : ill. (some col.)
    Edition: 2nd ed.
    ISBN: 3540528385
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  • 3
    Call number: QZ241:3/20 ; QZ241:3/20/AV/Mag
    Keywords: Bile Duct Neoplasms / classification ; Bile Duct Neoplasms / pathology ; Gallbladder Neoplasms / classification ; Gallbladder Neoplasms / pathology ; Liver Neoplasms / classification ; Liver Neoplasms / pathology ; Pancreatic Neoplasms / classification ; Pancreatic Neoplasms / pathology
    Pages: 40 p., [25] leaves of plates : col. ill. + 98 slides
    ISBN: 9241760206
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    QZ241:3/20 available
    QZ241:3/20/AV/Mag on loan
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  • 4
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Eleven populations polymorphic for Adh F and S alleles were established from wild-caught D. melanogaster. Seven of the populations were founded from mass collections each of several hundred flies and the other four were isofemale lines. Subcultures from all eleven were maintained on one of four different types of medium—standard laboratory medium, standard media supplemented to 3% or 9% (v/v) ethanol, and simulated wine seepages. These subcultures were rescored for F and S gene frequencies after 10, 20 and 30 generations. Maximum-likelihood methods were then used to estimate selection coefficients among the Adh genotypes and analyses of deviance were carried out to test the coefficients against hypotheses of neutrality and various modes of selection. No significant selective changes in Adh frequencies were observed in the seven mass cultures on any of the four different media types. However, highly significant selective effects were detected in the four isofemale lines; these effects were homogeneous across the four lines and the four media types and the underlying fitness set was estimated as 1.00:1.04:1.09 for S/S:F/S:F/F.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Alcohol dehydrogenase (ADH) activity variation in male flies taken directly from seven natural populations ofDrosophila melanogaster is largely accounted for by segregation of alleles at theAdh structural gene locus. There was little overlap in the ADH activities ofAdh F andAdh s homozygotes. Body weights varied only slightly betweenAdh genotypes and contributed little to ADH variation. Between and within population variation in ADH activity and ADH protein in flies in the wild is mainly due to the relative frequencies ofAdh F andAdh s.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-3297
    Keywords: alcohol metabolism ; twins ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Blood alcohol measurements were obtained for 206 pairs of twins who had ingested a standard dose of alcohol (0.75 g/kg body weight) and repeat measurements were obtained for 40 of these pairs on a second occasion. The repeatability of the peak blood alcohol concentration (BAC) was 0.66, that of the rate of elimination was 0.39, and that of the time to peak BAC was 0.27. Only a small portion of the nonrepeatable variance could be explained by measurement error or drinking experience. It is concluded that short-term environmental factors exercise considerable influence on alcohol metabolism, particularly in the absorption phase. All of the repeatable variance in peak BAC and rate of elimination was due to genetic factors. Only a small proportion of any of the genetic variance could be explained by individual differences in weight, adiposity, or lung function. Likewise, these three factors were unable to account for the fact that females had higher BACs than males during both absorption and elimination.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-3297
    Keywords: alcohol susceptibility ; psychomotor performance ; twins ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract A battery of psychomotor tasks and physiological measures was administered to 206 pairs of twins before alcohol and then three times at hourly intervals after they ingested a standard dose of ethanol (0.75 g/kg body weight). Repeat measurements were obtained for 41 of these pairs on a second occasion. Performance on motor coordination, standing steadiness, pursuit rotor, arithmetic computation, and reaction-time tasks deteriorated after alcohol, but decrements on the five tasks were generally independent of each other. Measurements of blood pressure, pulse rate, and skin temperature were all elevated following alcohol intake, but these responses were also uncorrelated. The variance in many of these measures increased after alcohol. An analysis of covariance structure revealed that most of this additional variance exposed by alcohol was genetic in origin, particularly for standing steadiness, pursuit rotor, arithmetic computation, and pulse rate. Up to 50% of the variance in body sway after alcohol was estimated to be due to genetic factors expressed only under the influence of alcohol. Although significant correlations were found with blood alcohol concentration, previous drinking experience, and the personality trait Extraversion, little of the genetic variance exposed by alcohol could be explained by these predictors. It is concluded that the sources of the considerable genetic variation affecting performance under alcohol must be sought elsewhere.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-4927
    Keywords: alcohol dehydrogenase ; Adh null alleles ; activity ; cross-reacting material (CRM)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Twenty-three alcohol dehydrogenase (ADH) putative null alleles extracted from four Tasmanian (Australia) populations ofDrosophila melanogaster produce no ADH activity and are unable to form active heterodimers with eitherAdh F orAdh S . Twelve of these nulls were tested by enzyme-linked immunosorbent assay (ELISA) and did not produce any ADH cross-reacting material (CRM). The null homozygotes had similar, but slightly lower, mortalities on ethanol-supplemented media compared to an artifically induced null allele. Heterozygotes between the null alleles and standardAdh F andAdh S alleles had intermediate ADH activity and CRM levels.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-3297
    Keywords: marker associations ; haptoglobin ; Wechsler Adult Intelligence Scale (WAIS)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Data on variation in eight polymorphic marker systems and some psychometric traits collected for other purposes in a group of Oxfordshire villages were examined for possible associations. Of a number that appeared statistically significant, one between haptoglobin and aspects of Wechsler Adult Intelligence Scale (WAIS) IQ seemed particularly interesting, since the haptoglobin variation is also associated with “within-family” social mobility. After using a multiple regression approach to allow for the possible effects on IQ of sex, geographical location, social class, and family structure, the association between haptoglobin and performance IQ became even stronger. This procedure removed the evidence for all the other associations except for one between Kell blood group and IQ. When the haptoglobin variation was examined in relation to the component subtests of the WAIS, the association turned out to arise entirely from the block design element.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-4927
    Keywords: KP-ELEMENT ; ENHANCERS ; TRANSVECTION ; DROSOPHILA MELANOGASTER
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Trans effects at the sn-glycerol-3-phosphatedehydrogenase locus (Gpdh) of Drosophilamelanogaster give rise to an increase in GPDHactivity and mRNA from the wild-type allele inheterozygotes with some low-activity alleles. Either the low-activityalleles that induce the effect have a defectiveP-element inserted between the promoter and a downstreamintronic enhancer element or the promoter region is deleted. The trans effect is pairing dependent,characteristic of transvection at some other loci. Thedefective P-elements that mediate transvection arelocated between the promoter and at least up to 6 bp downstream of the transcription startsite. Transvection at Gpdh appears similar to the“enhancer action in trans” mode at theyellow locus.
    Type of Medium: Electronic Resource
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