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  • 1
    Call number: M120:286
    Pages: 246 p. : ill.
    ISBN: 9783848725168
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    M120:286 departmental collection or stack – please contact the library
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  • 2
    Keywords: Medicine ; Immunology ; Vaccines ; Biomedicine ; Vaccine ; Immunology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Molecular vaccines - from prophylaxis to therapy -- Vaccine immunology -- Vaccines for infectious diseases -- Cancer vaccines.℗
    Abstract: This book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clinicians interested in new developments in molecular vaccine research and application in infections and cancer
    Pages: XXVIII, 447 p. 88 illus., 80 illus. in color. : online resource.
    ISBN: 9783709114193
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  • 3
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    Cham : Springer International Publishing
    Keywords: Medicine ; Immunology ; Vaccines ; Biomedicine ; Vaccine ; Immunology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Non-infectious and non-cancer vaccines -- Adjuvants and nanotechnology -- In silico and delivery systems -- Patenting, manufacturing, registration
    Abstract: This title discusses all aspects of non-infectious and non-canceŕ€“ so called NINC ́€“ vaccines. Hypertension, diabetes and allergy vaccine development are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclinical to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Administration) guidelines are described in-depth.℗ Practical perspectives of patentability of vaccines are discussed.℗ The book is therefore of interest for researchers and clinicians engaged in vaccine development and molecular vaccine application
    Pages: XXVIII, 870 p. 98 illus., 74 illus. in color. : online resource.
    ISBN: 9783319009780
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  • 4
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    Cham : Springer International Publishing
    Keywords: Medicine ; Immunology ; Vaccines ; Molecular Biology ; Biomedicine ; Vaccine ; Immunology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Part I: Scientific Bases -- From Pasteur to personalized vaccines -- Cell biology & Molecular Biology -- Basic vaccine immunology -- Gut and mucosa immunity -- Pediatric immunology -- Elderly immunology -- Tumor immunology -- Part II: Design of vaccines -- Antigen screening/selection processes -- Modes of action of vaccines -- Types of vaccines -- Adjutants -- Nanotechnologies -- Delivery technologies -- In silico vaccine design -- Infection vaccinology -- NINC vaccines -- Tumor vaccinology -- Vet vaccines -- Part III: Production and Public Health Issues -- Formulation -- Biomanufacturing -- Preclinical and clinical trials: basic principles -- Vaccine safety - assessment of adverse effects -- Ethical issues -- Registration process: Evidence-based vaccine trials -- Future vaccines
    Abstract: This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines. The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development
    Pages: XIX, 373 p. 219 illus., 31 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319258324
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  • 5
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    Cham : Springer International Publishing
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Abstract: This book integrates discoveries from recent years to show the diversity of molecular mechanisms that contribute to memory consolidation, reconsolidation, extinction, and forgetting. It provides a special focus on the processes that govern functional and structural plasticity of dendritic spines.℗ In nine chapters, new and important ideas related to learning and memory processes are presented. Themes discussed include℗ the role of AMPA receptors in memory, two signalling cascades involved in local spine remodelling and memory, the role of extracellular matrix proteins in memory, the regulation of gene expression and protein translation, and mechanisms of retrieval-induced memory modulation and forgetting. The editors believe that the study of these topics represents a great step toward understanding the complexity of the brain and the processes it governs
    Pages: XI, 181 p. 29 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319243641
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  125. Kongress der Deutschen Gesellschaft für Chirurgie; 20080422-20080425; Berlin; DOC08dgch9621 /20080416/
    Publication Date: 2008-04-14
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 7
    Keywords: CANCER ; CELLS ; EXPRESSION ; GROWTH ; tumor ; AGENTS ; Germany ; MODEL ; MODELS ; THERAPY ; POPULATION ; SITE ; SITES ; GENE ; GENE-EXPRESSION ; GENES ; HYBRIDIZATION ; TISSUE ; TUMORS ; gene therapy ; MICE ; INFECTION ; MARKER ; ANTIGEN ; DENDRITIC CELLS ; SUPPRESSION ; VARIANTS ; cytokines ; virus ; DELETION ; IN-SITU ; LYMPHOMA ; gene expression ; VECTOR ; MARKERS ; MELANOMA ; LYMPHOCYTES ; DERIVATIVES ; SURVEILLANCE ; MINUTE VIRUS ; GENE-THERAPY ; AUTONOMOUS PARVOVIRUSES ; autonomous parvovirus ; AGENT ; in situ hybridization ; INFILTRATION ; PROGRAM ; targeted ; PROTOCOL ; INTERLEUKIN-12 ; dendritic cell ; ABILITY ; parvovirus minute virus of mice
    Abstract: Due to their oncolytic properties and apathogenicity, autonomous parvoviruses have attracted significant interest as possible anticancer agents. Recent preclinical studies provided evidence of the therapeutic potential of minute virus of mice prototype strain (MVMp) and its recombinant derivatives. In a murine model of hemangiosarcoma, positive therapeutic outcome correlated with high intratumoral expression of MVMp-encoded genes in tumors and lymphoid organs, especially in tumor-draining lymph nodes. The source and relevance of this extratumoral expression, which came as a surprise because of the known fibrotropism of MVMp, remained unclear. In the present study, we investigated (i) whether the observed expression pattern occurs in different tumor models, (ii) which cell population is targeted by the virus, and (iii) the immunological consequences of this infection. Significant MVMp gene expression was detected in lymphoid tissues from infected tumor-free as well as melanoma-, lymphoma-, and hemangiosarcoma-bearing mice. This expression was especially marked in lymph nodes draining virus-injected tumors. Fluorescent in situ hybridization analysis, multicolor fluorescence-activated cell sorting, and quantitative reverse transcription-PCR revealed that MVMp was expressed in rare subpopulations of CD11b (Mac1)-positive cells displaying CD11c(+) (myeloid dendritic cells [MDC]) or CD45B (B220(+) [131 lymphocytes]) markers. Apart from the late deletion of cytotoxic memory cells (CD8(+) CD44(+) CD62L(-)), this infection did not lead to significant alteration of the immunological profile of cells populating lymphoid organs. However, subtle changes were detected in the production of specific proinflammatory cytokines in lymph nodes from virus-treated animals. Considering the role of 131 lymphocytes and MDC in cancer and immunological surveillance, the specific ability of these cell types to sustain parvovirus-driven gene expression may be exploited in gene therapy protocols
    Type of Publication: Journal article published
    PubMed ID: 15731246
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  • 8
    Keywords: CANCER ; CELLS ; EXPRESSION ; GROWTH ; INVASION ; SURVIVAL ; carcinoma ; TRIAL ; CANCER-PATIENTS ; HUMAN TUMOR-CELLS ; TRANSFERRIN RECEPTOR ; QUALITY-OF-LIFE ; ANEMIA ; CHRONIC HEART-FAILURE ; EPOETIN-BETA ; STIMULATING AGENTS
    Type of Publication: Journal article published
    PubMed ID: 21829709
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  • 9
    Keywords: EXPRESSION ; THERAPY ; MICE ; DENDRITIC CELLS ; T-CELLS ; MINUTE VIRUS ; vaccination ; autonomous parvovirus ; PANCREATIC-CANCER ; VIRUS-INFECTION
    Abstract: Treatment of cancers by means of viruses, that specifically replicate in (oncotropism) and kill ( oncolysis) neoplastic cells, is increasingly gaining acceptance in the clinic. Among these agents, parvoviruses have been shown to possess not only direct oncolytic but also immunomodulating properties, serving as an adjuvant to prime the immune system to react against infected tumors. Here, we aimed to establish whether immunomodulating mechanisms participate in the recently reported therapeutic potential of parvoviruses against pancreatic carcinoma. Using adoptive transfer experiments we discovered that the transfer of splenocytes of donor rats harboring H-1PV-treated orthotopic PDAC tumors could significantly prolong the survival of naive tumor-bearing recipients, compared to those receiving cells from mock-treated donors. Closer investigation of immunological parameters in infected donor rats revealed that virus-induced interferon gamma production and cellular immune response played an important role in this effect. These data have also preclinical relevance since abortive H-1PV infection of human peripheral blood mononuclear cells or cocultivation of these cells with H-1PV-preinfected pancreatic cancer cells, resulted in enhancement of innate and adaptive immune reactivity. Taken together our data reveal that oncolytic H-1PV modulates the immune system into an anticancer state, and further support the concept of using parvoviruses in the fight against pancreatic cancer.
    Type of Publication: Journal article published
    PubMed ID: 21124075
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  • 10
    Keywords: PATHWAYS ; TARGET ; IDENTIFICATION ; p53 ; TUMOR-INITIATING CELLS
    Abstract: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies. Cancer stem cells (CSCs), which are not targeted by current therapies, may be the reason for pronounced therapy resistance. A new treatment option in phase II trials is cabozantinib that inhibits the pancreatic CSC surface marker and tyrosine kinase receptor c-Met. The purpose of this study was to evaluate the effect of cabozantinib to stem-like features and therapy resistance. Established PDA cell lines, a gemcitabine-resistant subclone, non-malignant pancreatic ductal cells and primary spheroidal cultures from patient tumors were analyzed by MTT-assay, flow cytometry, colony and spheroid formation assays, western blotting, qRT-PCR, antibody protein array, immunohistochemistry and morphological features. Cabozantinib inhibited viability and spheroid formation and induced apoptosis in malignant cells with minor effects in non-malignant cells. After long-term cabozantinib treatment, PDA cells had altered anti- and pro-apoptotic signaling, but still responded to cabozantinib, as apoptosis only slightly decreased and viability only slightly increased suggesting a low resistance-inducing potential of cabozantinib. In parallel, c-Met expression and the pluripotency transcription factor SOX2 were downregulated, which might counteract development of full therapy resistance in long-term treated subclones. In single-treatment studies, cabozantinib increased efficacy of gemcitabine. Most importantly, cabozantinib strongly induced apoptosis and reduced viability in PDA cell lines, which are completely resistant toward gemcitabine. In primary, CSC-enriched spheroidal cultures cabozantinib downregulated CSC markers SOX2, c-Met and CD133 and induced apoptosis. These findings suggest that the clinical use of cabozantinib may be more effective than current chemotherapeutics.
    Type of Publication: Journal article published
    PubMed ID: 23661005
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