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  • 1
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    Berlin ; New York : Springer-Verlag
    Call number: QZ241:158
    Keywords: Cytodiagnosis / trends ; Cytological Techniques / trends ; DKFZ-publications
    Pages: xxx, 450 p. : ill.
    ISBN: 3540191682
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  • 2
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    Heidelberg : Deutsches Krebsforschungszentrum
    Call number: ZZ1986:14 ; ZZ1986:14a/Mag
    Keywords: Tumor Cells, Cultured ; Models, Biological ; Animal Testing Alternatives ; DKFZ-publications
    Pages: 162 p.
    Edition: Als Manuskript vervielfältigt.
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    ZZ1986:14 available
    ZZ1986:14a/Mag departmental collection or stack – please contact the library
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  • 3
    Call number: QZ200:109 ; QZ200:109a/Mag
    Keywords: Cancer research / Congresses ; Medical Oncology ; Research
    Pages: 56 p. : ill.
    ISBN: 3512003540
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    QZ200:109 available
    QZ200:109a/Mag departmental collection or stack – please contact the library
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  • 4
    Call number: ZZ1996:2
    Keywords: Cervix Neoplasms / epidemiology ; Cervix Neoplasms / pathology ; Cytodiagnosis ; Diagnosis, Computer-Assisted ; Mass Screening ; DKFZ-publications
    Pages: xii, 137 p.
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    ZZ1996:2 available
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  • 5
    Call number: QZ202:140
    Keywords: Attitude to Health ; Motivation ; Neoplasms / prevention & control ; Questionnaires ; DKFZ-publications ; Germany, West
    Pages: 119 p. : ill.
    ISBN: 3170040839
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  • 6
    ISSN: 1432-0738
    Keywords: 2,4-D ; Cell Differentiation ; Chromatin ; DNA-Synthesis ; Growth Inhibition ; 2,4-D ; Zelldifferenzierung ; Chromatin ; DNS-Synthese ; Wachstumshemmung.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß des Herbicides 2,4-Dichlorphenoxyessigsäure auf das Wachstum von Skelettmuskelzellen des Huhns in Zellkulturen wurde anhand morphologischer Veränderungen und durch cytophotometrische Bestimmung des DNS-Gehaltes von Zellkernen untersucht. Aus der Verteilung der DNS-Meßwerte wurden Synthesekurven abgeleitet. Bis zu Konzentrationen von 60 μg/ml waren keine deutlichen Effekte erkennbar. Dagegen verursachten Konzentrationen von 600 μg/ml einen Verlust der Zelldifferenzierung, bestehend in einem Fehlen der polaren Wachstumsrichtung der Zellen, verminderter Faserbildung und einem Ansteigen der Kern-Plasma-Relation. Damit war eine Heterochromatisierung des Desoxyribonucleoproteins in den Zellkernen verbunden. Nach 44stündiger Einwirkung traten vereinzelte Zellnekrosen auf. Die relative DNS-Synthesedauer war gegenüber den Kontrollen auf das 1,5fache verlängert. Die Anzahl der Zellen in der G2-Phase war nach 44 Std Einwirkungsdauer vermindert. Aus den Befunden wird auf eine dosisabhängige Wachstumshemmung von Vertebraten-Zellen durch 2,4-D geschlossen, die während der DNS-Synthese wirksam ist. Die morphologischen Veränderungen der Kernmatrix legen die Vermutung nahe, daß durch 2,4-D die Aktivität des Chromatins direkt beeinflußt wird.
    Notes: Abstract The influence of the herbicide 2,4-Dichlorophenoxyacetic acid on the growth of cultured chicken muscle cells was studied by observing morphological changes and by cytophotometric measurement of the DNA content of individual cells. DNA-synthesis curves were derived from the distribution of DNA values. No marked effects were observed at a concentration of 60 μg per liter. In contrast, doses of 600 μg per liter caused a loss in cell differentiation consisting of a partial lack of polar orientation, diminished formation of fibers, and an increase of the N/C ratio. The nuclear matrix of desoxyribonucleoprotein (DNP) changed to a more heteropycnotic structure. Isolated cell necroses were found after 44 hrs of exposure. When compared to the controls, the relative DNA synthesis time was found to be prolonged 1.5-fold. The number of cells in the G2 phase decreased during 44 hrs of exposure. It is concluded from this results that the dosedependent growth inhibition of 2,4-D on vertebrate cells in culture takes effect during DNA synthesis. The morphological changes of the nuclear structure suggest that 2,4-D directly affects the template activity of the DNP matrix.
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  • 7
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A dual laser beam excitation device for flow analysis of biological particles has been developed. The aid of this arrangement is to increase the range of fluorescent agents employed so far in quantitative and qualitative cytochemistry. Combining an argon ion and a helium-cadmium laser two color fluorescence measurements were performed employing propidium iodide as a DNA stain and fluorescamine which stains total protein in fixed cells. Energy transfer processes between the antibiotic and DNA specific dye mithramycin and propidium iodide both being bound to nuclear chromatin were analyzed. Utilization of energy transfer processes is generally discussed as a mean to extract information about the structure and conformation of nuclear chromatin in situ. The application of a crypton ion laser with three lines near 400 nm and a single line at 350 nm having a light output in each range of nearly one Watt gives the opportunity of utilizing DNA fluorochromes which have an excitation maximum in the deep blue region. DNA spectra are shown employing mithramycin, the benzimidazol derivative 33258 (Hoechst) and the indol compound DAPI which has a high DNA specifity combined with a great stability under UV illumination. By separating two focussed laser beams at their intereecting points with the liquid sample stream the trajectory of each flowing cell crosses the beams sequentially, which causes a solitary dual excitation of each cell. The advantages of a solitary excitation device compared with a simultaneous one is discussed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 370 (1976), S. 97-102 
    ISSN: 1432-2307
    Keywords: Carcinogenesis ; Transmaternal ; DMBA-initiation ; TPA-promotion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary DMBA which is applied transmaternally via the mothers milk can initiate tumour cells in the F-1 generation. Subsequent application of the tumour promoter TPA to the back skin of the young animals induced the formation of skin papillomas and carcinomas. Animals treated according to this scheme also developed malignant neoplasms in the other organs. Control animals treated with DMBA only, rarely developed tumours, whereas treatment with TPA alone had no effect. This variation of the Berenblum-experiment suggests that the transfer of carcinogens in human milk should be considered in addition to transplacental carcinogen transfer as a potential hazard to the developing human infant.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 330 (1957), S. 35-84 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 345 (1968), S. 71-92 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Der Formwandel der menschlichen Zungenschleimhaut wurde mit einer kombinierten Methode an Grenzflächen- und histologischen Präparaten von 125 Individuen untersucht und im Detail beschrieben. 2. Die Grenzfläche weist lokale, alters- und vor allem in der ersten und zweiten Dekade auch geschlechtsgekoppelte Unterschiede des Reteleistenaufbaues auf. 3. Bei jugendlichen Erwachsenen erreicht das Relief seine höchste Differenzierung. 4. Die hervorstechende Altersveränderung besteht in einer Reduzierung der Reteleisten, die mit zunehmendem Alter fortschreitet und mit der Umwandlung des Reteleisten- in ein Retezapfenmuster endet. Dieser Vorgang setzt beim männlichen Geschlecht erheblich früher ein als beim weiblichen. Jenseits des 70. Lebensjahres ist bei beiden Geschlechtern die Reduktion abgeschlossen. 5. Die Vascularisation der Tunica propria nimmt von der 4. Dekade an in zunehmendem Maße ab. Dagegen steigt die Tendenz zur Einlagerung rundzelliger Infiltrate in diffuser oder massierter Ansammlung, sowie die Ablagerung von Fettgewebe zwischen Tunica propria und Stratum reticulare. 6. Das konstruktive Prinzip der Epithelgliederung wird diskutiert und als belastungsfähige Konstruktion erkannt. Diese bleibt auch im Alter erhalten, indem aus der septalen Gliederung eine Säulenkonstruktion entsteht. 7. Die Erfassung des Altersformwandels der Zunge ist ein Beitrag zur „Differenzierenden Pathologie der Lebensalter“ im Sinne von Rössle. Pathologische Abweichungen dürfen nur auf die jeweils alterbedingte Norm und nicht auf ein anatomisches „Idealbild“ bezogen werden.
    Notes: Summary 1. Structural changes in the mucosa of the human tongue were studied and described in detail in 125 autopsies using a method that combined preparations of the undersurface-relief with histology. 2. The undersurface-relief disclosed local, age-dependent differences in the structure of the interpapillary ridges, but above all, differences in the first and second decades dependenton sex. 3. The undersurface-relief was most highly differentiated in young adults. 4. With aging the most striking change was the reduction in the interpapillary ridges or plates, which in old age ended as stubly rete pegs. This alteration appeared considerably earlier in men than in women. Beyond the age of 70, however, the altered ridges were found in both sexes. 5. After the fourth decade, the vascularization of the tunica propria diminished. In contrast, diffuse or focal infiltrates of round cells increased, and the fat tissue between the tunica propria and stratum reticulare became more abundant. 6. The structural principle of the epithelial segmentation is discussed; it is conceived of as a construction related to functional stress. With aging the relationship persists, although the epithelial plate-like structures develop into pegs. 7. The structural change occurring in the tongue with aging serves as a contribution to Rössle's “Pathologic Differentiation of Age Groups”. Pathologic variations should be related only to changes normally found at an age and not to an “ideal anatomical state”.
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