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  • 1
    Unknown
    New York, NY : Springer
    Keywords: Pharmaceutical technology ; Biochemistry ; Cell Physiology ; Pharmaceutical Sciences/Technology ; Biochemistry, general ; Cell Physiology ; Springer eBooks
    Description / Table of Contents: Design Principles for Intestinal Permeability of Cyclic Peptides -- Strategies to Enhance Metabolic Stabilities -- Designing Cell-Permeable Macrocyclic Peptides -- Computational Methods for Studying Conformational Behaviors of Cyclic Peptides -- Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein-Protein Interactions -- Design of Cyclic Peptides as Protein Recognition Motifs -- Design and Synthetic Strategies for Helical Peptides -- Click Chemistry for Cyclic Peptides Drug Design -- Frontier between Cyclic Peptides and Macrocycles -- Building upon Nature’s Framework: Overview of Key Strategies towards Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles -- Design of Oxytocin Analogs -- DNA-Encoded Macrocyclic Peptide Library -- Peptide Display Technologies -- Discovery of Functional Macrocyclic Peptides by Means of the RaPID System -- Genetic Selections with SICLOPPS Libraries: Towards the Identification of Novel Protein-Protein Interaction Inhibitors and Chemical Tools
    Abstract: This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature’s cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field. Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields
    Pages: X, 332 p. 138 illus., 80 illus. in color. : online resource.
    ISBN: 9781493995042
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  • 2
    Call number: YY Diss Goet/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 81 p.
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    YY Diss Goet/Mag departmental collection or stack – please contact the library
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  • 3
    Keywords: Monoclonal antibodies ; Medical laboratories ; Antibodies ; Laboratory Medicine ; Springer eBooks
    Description / Table of Contents: 1. Flow Cytometry: Definition, History, and Uses in Biotechnology -- 2. Physics of a Flow Cytometer -- 3. The Language of Flow Cytometry and Experimental Setup -- 4. Fluorochrome Choices for Flow Cytometry -- 5. Compensation -- 6. Primary and Seconardy Antibodies and Their Use in Flow Cytometry -- 7. Experimental Considerations with Data Sets as Examples -- 8. Cell Enrichment -- 9. Surface and Intracellular Staining Protocols for Flow Cytometry -- 10. Troubleshooting
    Abstract: Flow cytometry allows for the measurement of different aspects of a cell or particles in real time. Applications include quantifying various types of T cells to determine the presence of various immune disorders, such as whether HIV has progressed to AIDS, studying the dynamics of immune signaling in cells to detect the suppression of normal immune function, and analyzing biopsy specimens for tumors, to aid in cancer diagnosis and prognosis. In addition to simplifying the technique and using vocabulary accessible to those not trained in cell biology and immunology, the book includes the following 4 unqiue features: 1) Tips on how to set up an experiment for flow cytometry optimially 2) An expanded data set of flow staining including multiparameter flow cytometry 3) Detailed staining protocols for flow cytometry (ex. protocols optimized for transcription factors, secreted cytokines, phospho-antibodies, and surface antigens) 4) Section devoted to antibody development and conjugation
    Pages: XVII, 219 p. 117 illus., 113 illus. in color. : online resource.
    ISBN: 9783319980713
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  • 4
    Call number: M050:23
    Keywords: Politics / Germany ; Economics ; Mass Media / United States
    Pages: 303 p.
    ISBN: 3430130115
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    M050:23 departmental collection or stack – please contact the library
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  • 5
    Keywords: Medicine ; Radiology, Medical ; Interventional radiology ; Neurology ; Ophthalmology ; Medicine & Public Health ; Imaging / Radiology ; Diagnostic Radiology ; Neuroradiology ; Interventional radiology ; Neurology ; Ophthalmology ; Springer eBooks
    Pages: : digital
    ISBN: 9783540688891
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  • 6
    Keywords: Medicine ; Toxicology ; Alternative Medicine ; Medicine & Public Health ; Medicine/Public Health, general ; Complementary & Alternative Medicine ; Pharmacology/Toxicology ; Springer eBooks
    Pages: : digital.
    ISBN: 9788847023918
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  • 7
    Unknown
    Upper Saddle River, NJ : Addison-Wesley
    Call number: B080:228
    Keywords: Java (Computer program language) ; Parallel programming (Computer science) ; Threads (Computer programs)
    Pages: xx, 403 p. : ill.
    ISBN: 0321349601
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  • 8
    Call number: YY Diss Weck/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 99 p., ILL.
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  • 9
    Keywords: Medicine ; Alternative Medicine ; Emerging infectious diseases ; Medicine & Public Health ; Medicine/Public Health, general ; Complementary & Alternative Medicine ; Infectious Diseases ; Springer eBooks
    Pages: : digital.
    ISBN: 9782817800585
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  • 10
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The sensitizing potency of formaldehyde and phenol during anatomy dissecting was investigated. The objective was to determine whether exposure induces specific IgE or IgG against formaldehyde-albumin or phenol-albumin. Methods: In 27 medical students, specific IgE against formaldehyde-albumin by RAST plus ELISA and specific lgE against phenol-albumin by ELISA were assessed. In addition, specific IgG against formaldehyde-albumin was assessed in 23 students. Symptoms before and during dissecting were assessed, and indoor formaldehyde and phenol were measured. Results: Mean indoor formaldehyde was 0.265±0.07 mg/m3, and mean indoor phenol was 4.65±2.96 mg/m3. Specific IgE/IgG against formaldehyde-albumin was not found at the beginning. Four students developed specific IgE against formaldehyde-albumin (RAST classes of ≥2.0), and all four also had specific IgE in the ELISA, but IgG against formaldehyde-albumin was not found. Specific IgE against phenol-albumin was not seen. Itch and paresthesia of the hands (PP〈0.00001), dizziness (P〈0.008), burning eyes (P〈0.01), headache, sneezing, epistaxis, gingival bleeding, oral or pharyngeal itch, and shortness of breath were experienced. Conclusion: Formaldehyde exposure during dissecting may induce specific IgE, but not IgG, against formaldehyde-albumin. Sensitization did not correlate with symptoms.
    Type of Medium: Electronic Resource
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