Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds731 /20070906/
    Publication Date: 2007-09-07
    Keywords: Nevi ; children & adolescents ; survey ; Lithuania ; ddc: 610
    Language: English
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  12. Deutscher Kongress für Versorgungsforschung; 20131023-20131025; Berlin; DOCPO5-1-10-315 /20131025/
    Publication Date: 2013-10-26
    Keywords: Dermatologie ; Versorgung ; Europa ; regionale Unterschiede ; ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  12. Deutscher Kongress für Versorgungsforschung; 20131023-20131025; Berlin; DOCPO2-1-05-327 /20131025/
    Publication Date: 2013-10-26
    Keywords: Versorgung ; Malignes Melanom ; Europa ; ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: RECEPTOR ; APOPTOSIS ; CELLS ; EXPRESSION ; tumor ; CELL ; COMBINATION ; Germany ; human ; PATHWAY ; PATHWAYS ; DEATH ; PROTEIN ; PROTEINS ; NF-KAPPA-B ; TUMOR-NECROSIS-FACTOR ; LIGAND ; BIOLOGY ; CELL-LINES ; DOWN-REGULATION ; MOLECULAR-BIOLOGY ; SUPPRESSION ; SIGNAL ; TARGET ; resistance ; CELL-DEATH ; UP-REGULATION ; genetics ; CELL-LINE ; MODULATION ; MELANOMA ; METASTATIC MELANOMA ; SIGNALING PATHWAY ; ONCOGENE ; LIGANDS ; HUMAN KERATINOCYTES ; sensitivity ; heredity ; TRAIL ; DEATH RECEPTORS ; SIGNALING COMPLEX ; APOPTOSIS-INDUCING LIGAND ; signaling ; molecular biology ; molecular ; ONCOLOGY ; MELANOMA-CELLS ; C-FLIP ; death receptor ; LOSSES ; ENGLAND ; PREDICT ; BCL-2 FAMILY ; CELL BIOLOGY ; cFLIP ; RECEPTOR-SELECTIVE MUTANTS ; TRAIL-R1 ; TRAIL-R2
    Abstract: Death ligands such as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and certain forms of CD95L are attractive therapeutic options for metastatic melanoma. Since knowledge about the regulation of death receptor sensitivity in melanoma is sparse, we have analysed these signaling pathways in detail. The loss of CD95 or TRAIL-R1, but not of TRAIL-R2, surface expression correlated with apoptosis sensitivity in a panel of melanoma cell lines. In contrast, the expression of proteins of the apical apoptosis signaling cascade (FADD, initiator caspases-8 and cFLIP) did not predict apoptosis sensitivity. Since both TRAIL-R1 and -R2 transmit apoptotic signals, we asked whether cFLIP, highly expressed in several of the cell lines tested, is sufficient to maintain resistance to TRAIL-R2-mediated apoptosis. Downregulation of cFLIP in TRAIL-R2-positive, TRAIL-resistant IGR cells dramatically increased TRAIL sensitivity. Conversely ectopic expression of cFLIP in TRAIL-sensitive, TRAIL-R2-expressing RPM-EP melanoma cells inhibited TRAIL- and CD95L- mediated cell death. Thus, modulation of cFLIP is sufficient to sensitize TRAIL-R2-expressing cells for TRAIL. Taken together, albeit expressing all proteins necessary for death receptor-mediated apoptosis, TRAIL-R1 negative melanoma cells cannot undergo TRAIL- or CD95L-induced apoptosis due to expression of cFLIP. Hence, cFLIP represents an attractive therapeutic target for melanoma treatment, especially in combination with TRAIL receptor agonists
    Type of Publication: Journal article published
    PubMed ID: 18084329
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: TRAIL ; MELANOMA ; CELLS ; RECEPTOR ; APOPTOSIS ; CELL ; human ; DEATH ; death receptor
    Type of Publication: Meeting abstract published
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Photochemotherapie ; Extrakorporale Photopherese ; Kutane T-Zell Lymphome ; Progressive systematische Sklerodermie ; Graft versus host Krankheit ; Key words Photochemotherapy ; Extracorporeal photopheresis ; Cutaneous T-cell lymphoma ; Progressive systemic scleroderma ; Graft-versus-host disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Extracorporeal photophoresis (ECP), a therapeutic modality that has been under investigation for some years, is based on separation of a leucocyte/lymphocyte-enriched cell fraction from the peripheral blood, extracorporeal treatment of the cells with 8-MOP/UVA and subsequent reinfusion of the cells in the patient. Its main effects seem to consist in changes to the immunologic behaviour of the photoinactivated/modulated cells. The immune response of the host is obviously stimulated by this treatment. ECP is normally performed for 4 h per day on 2 consecutive days every 4 weeks. The treatment is well tolerated and causes few side effects. In our department, 1210 ECP treatments were administered to 41 patients between 1990 and 1994 and a preliminary evaluation was performed. These patients included 21 with cutaneous T-cell lymphoma (CTCL), 10 with progressive systemic scleroderma, 4 with chronic graft-versus-host disease and 1 each with pemphigus vulgaris, epidermolysis bullosa acquisita, lupus erythematosus and cutaneous mucinosis. Patients with erythroderma and preserved immunocompetence achieved the best responses of all patients with CTCL. A treatment combining ECP with rlFN-α, PUVA and/or radiation was also successful in patients with tumour-stage CTCL and lymph node involvement. Progressive systemic scleroderma responded in more than 50% of our cases. Treatment results were impressive in 4 patients with chronic graft-versus-host disease presenting with sclerodermatous and lichenoid changes of the skin and mucous membranes. A clear improvement was also observed in the patient with pemphigus vulgaris refractory to standard therapies and in another patient with scleromyxoedema (Arndt-Gottron syndrome). The effectiveness of ECP seems to be quite well established in CTCL, but remains to be examined in autoimmune dermatoses. ECP is an attractive addition to the dermatological therapies available but our experience is still preliminary.
    Notes: Zusammenfassung Die Extrakorporale Photopherese (ECP) stellt ein seit fast 10 Jahren geübtes und inzwischen erprobtes Behandlungsverfahren dar, bei dem eine leukozytenangereicherte Zellfraktion aus dem peripheren Blut separiert, extrakorporal mit 8-MOP/UVA behandelt und anschließend dem Patienten reinfundiert wird. Hierbei werden Änderungen des immunologischen Verhaltens der photoinaktivierten und -modulierten Zellen bewirkt, die nach Reinfusion eine Immunantwort des Körpers induzieren sollen. Die ECP wird in der Regel in 4-wöchigen Abständen an 2 aufeinanderfolgenden Tagen über jeweils 4 Stunden durchgeführt. Sie ist gut verträglich und nebenwirkungsarm. Wir haben 1990 bis 1994 1210 ECP-Behandlungen bei 41 Hautkranken durchgeführt und vorläufig ausgewertet, darunter 21 Patienten mit kutanem T-Zell-Lymphom, 10 mit progressiver systemischer Sklerodermie und 4 mit chronischer Graft-versus-Host-Krankheit. CTCL-Patienten mit Erythrodermie und erhaltener Immunkompetenz sprachen am besten auf die ECP an. Im Rahmen einer Kombinationsbehandlung mit rIFN-α, PUVA und/oder lokaler Röntgenbestrahlung ließen sich auch fortgeschrittene CTCL im Tumorstadium mit LK-Befall erfolgreich mittels ECP angehen. Die Hälfte der Patienten mit PSS im aktiven Stadium spricht sehr gut an. Eindrucksvoll ist die Besserung der GvH-Krankheit mit sklerodermiformen Veränderungen. Kasuistische Erfahrungen mit günstigem Erfolg liegen uns bei Pemphigus vulgaris, Epidermolysis bullosa acquisita, Lupus erythematodes, kutaner Muzinose und Sklermyxödem Arndt-Gottron vor. Insgesamt dürfte die Wirkung der ECP bei cTCL und GvHD als weitgehend gesichert gelten, hingegen ist die Wirksamkeit bei Autoimmundermatosen noch weiter zu untermauern. Das Spektrum der Dermatotherapie erweitert sich durch das Verfahren der ECP erheblich.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 49 (1998), S. 520-528 
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 49 (1998), S. 421-434 
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Lernziel In der folgenden Übersicht wird der aktuelle Kenntnisstand hinsichtlich dermatologisch relevanter Erkrankungen vermittelt, die im Rahmen des Ferntourismus akquiriert und z.T. aufgrund der Inkubationszeit erst am Heimatort manifest werden können. Es handelt sich um Erkrankungen, die durch Protozoen, Arthropoden, Helminthen, Bakterien, Viren, Coelenterata, Mollusca/Tentaculata und Echinodermata hervorgerufen werden. Jeweils beispielhaft wird das jeweilige Krankheitsbild hinsichtlich der Epidemiologie und des Vorkommens, der Symptomatik und Diagnostik, der Therapie, Prophylaxe sowie der Differentialdiagnosen vorgestellt.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The cyanoacrylate follicular biopsy is an established method for the examination of the horny layer and quantitative assessment of microcomedones. We have optimized the method by separating follicular casts mechanically from the cyanoacrylate strips.Objectives To use this method to analyse topical therapy-induced changes of the lipid composition in the sebaceous follicular infundibulum.Methods Both the follicular casts and the residual skin surface strip, the last representing a mixture of stratum corneum and surface lipids, were extracted twice with n-hexane–ethanol under ultrasonication, evaporated, redissolved in chloroform–methanol and separated by high-performance thin layer chromatography, using cholesterol sulphate, cerebroside, ceramide types 3 and 4, cholesterol, oleic acid, triolein, cholesterol oleate and squalene as standards. Identification was performed by computer-assisted densitometric analysis. Six patient groups receiving adapalene 0·1%, tretinoin 0·025%, clindamycin 1%, clindamycin 1% + tretinoin 0·025%, benzoyl peroxide 5% or benzoyl peroxide 5% + erythromycin 2% were investigated before and 12 weeks after application.Results A significant decrease in free fatty acid proportions combined with an increase in triglycerides was observed in the groups receiving antimicrobial therapy, supporting the hypothesis of lipolysis due to microbial colonization. The groups treated with topical retinoids showed an additional significant increase in ceramide subfractions, most probably reflecting their influence on epidermal keratinization.Conclusions Our method proved suitable for the detection of quantitative and qualitative changes in lipid profiles of both infundibulum cast content and surface lipids. It enabled simple, non-invasive and objective assessment of the most relevant lipid classes in the sebaceous infundibulum, and efficient monitoring of drug effects on the follicular infundibulum.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...