Blackwell Publishing Journal Backfiles 1879-2005
Process Engineering, Biotechnology, Nutrition Technology
This review discusses the anatomy of human odorant reception, with particular reference to the seven-helical transmembrane-protein superfamily of olfactory receptors, the concept of a novel multigene olfactory-receptor family, the location of the olfactory-receptor genes in the human genome and the characterization of the receptor proteins by cloning and overexpression. It then turns to the evidence for secondary message transduction following odorant binding, and the latest evidence on the structural analysis of G-protein coupled signalling as well as how the binding of odorant molecules to the transmembrane olfactory receptors is transmitted through the neural pathways to the brain, including the remarkable success in generating cDNA libraries from single neurons.
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