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  • 1
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report allergic sialadcnitis as a novel side-effect of naproxen, a non-steroidal anti-inflammatory drug (NSAID). Bilateral swelling of the major salivary glands and a rash occurred a few days after the patient had taken the drug. High-dose systemic corticosteroid therapy was required to control the disorder. Because the salivary gland swelling was not initially recognized as an adverse drug reaction, further doses of naproxen were given on two occasions, with similar results.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-4726
    Keywords: Ciliary beat frequency ; Mucociliary clearance ; Nasal cycle ; Nasal resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to investigate whether the ciliary beat frequency (CBF) is influenced by the nasal cycle. Nasal patency was assessed by active anterior rhinomanometry and immediately followed by measuring CBF in biopsies taken from the posterior aspect of the inferior turbinates in 22 healthy volunteers. CBF was determined in three different cells of each biopsy by means of a phase-contrast microscope and a photoelectrical cell. The signal was analyzed by a computed power spectrum. The frequency and its shift were calculated for a period of 20 s. The results were as follows: (1) no correlation was found between CBF and nasal patency; (2) CBF in one cell is constant to a high degree; (3) CBF of different cells in the same biopsy specimen varies considerably.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-4726
    Keywords: Calcitonin gene-related peptide ; Ciliary beat frequency ; Human upper respiratory cilia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Calcitonin gene-related peptide (CGRP) is one of the neuropeptides that is released in the human nasal mucosa after trigeminal nerve stimulation. We investigated the in vitro effect of CGRP on the ciliary beat frequency (CBF) of human upper respiratory cilia. Ciliated epithelium of freshly removed adenoidal tissues was used in all experiments. CBF was measured using a computerized photo-electric method. The results showed that CGRP exerted a significant dose-dependent stimulation on CBF in concentrations of 10-9-10-6 M (n = 10), with a maximum of 23%. Our findings indicate that CGRP in vivo may help to protect the airway epithelium by directly stimulating ciliary beat.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-4726
    Keywords: Allergic rhinitis ; Histamine ; Leukotriene ; C4 ; Ciliary beat frequency ; Human upper respiratory cilia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Decreased mucociliary transport can occur in patients with type I (IgE-mediated) allergic rhinitis or allergic asthma. This study investigated if the allergic mediators histamine and leukotriene C4 (LTC4) could interfere with ciliary beat frequency (CBF) of in vitro human upper respiratory cilia and eventually result in decreased mucociliary transport. Ciliated epithelium of human adenoid tissue was used in the experiments and CBF was determined using a computer-assisted photoelectric method. Histamine in concentrations of 10−6–10−3 M (n = 12) and LTC4 as 10−9–10−6 M solutions (n = 10) showed no statistically significant dose-dependent effect on CBF in vitro.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-4726
    Keywords: Key words Cryopreservation ; Ciliary beat frequency ; Sphenoid sinus mucosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In vitro studies of human ciliary activity require relatively large quantities of specimens of healthy ciliated epithelium. For this reason we investigated whether cryopreserved healthy mucosa taken from the sphenoid sinus during pituitary surgery would meet the demands of this type of study. The sinus mucosa from ten patients was immersed in two different cryopreservatives. One solution contained 10% dimethylsulfoxide (DMSO) as cryoprotector. The other contained glycerol as a part of human sperm preservation medium (HSPM). The ciliary beat frequency (CBF) was measured sequentially by a photoelectrical method: when specimens were fresh and then at intervals of 1 week, 1 month and 3 months after cryopreservation in liquid nitrogen and thawing. Mean CBF values recorded after thawing did not differ significantly from the values measured before cryopreservation. Prior to cryopreservation and after thawing, CBF did not change during a period of 4 h. Epithelia preserved in DMSO demonstrated that the low mean CBF (5.4 Hz) found was caused by a reversible ciliostatic effect of the medium. After thawing and rinsing with a neutral medium, CBF showed normal values. We conclude that sphenoid sinus mucosa is an appropriate source of ciliated mucosa for in vitro experiments. Since non-pathological ciliated epithelium can be maintained in a “mucosa bank,” our finding makes further studies of CBF of normal human respiratory epithelium in vitro a realistic goal.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-4726
    Keywords: Key words Vestibular schwannoma ; Tumor activity ; Vestibular compensation ; Electronystagmography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Vestibular function was studied in a group of 121 patients with unilateral vestibular schwannomas who were referred to University Hospital Utrecht between 1986 and 1996. Testing included the caloric test, torsion test, saccade test, smooth pursuit test and the registration of spontaneous nystagmus. Each patient’s symptoms were taken from a chart review. The size of the tumor was expressed as the maximum extrameatal diameter in the axial plane parallel to the petrous ridge as seen in magnetic resonance imaging or computed tomography. Large tumors were significantly more often accompanied by a more severe paresis on caloric testing, a smaller gain on torsion testing, spontaneous nystagmus, an abnormal saccade test and an abnormal smooth pursuit test. The presence of spontaneous nystagmus was significantly more frequently combined with an abnormal smooth pursuit and saccade test. There was a significant correlation between the slow component’s velocity of the spontaneous nystagmus and the size and progression of tumor. However, a specific relation between tumor size and central vestibular compensation could not be demonstrated.
    Type of Medium: Electronic Resource
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