Springer Online Journal Archives 1860-2000
Abstract Posttransplant lymphoproliferative disorders (PTLD), developing after immunosuppressive therapy in human organ-graft recipients, are, for the most part, Epstein-Barr virus-induced. The earlier the diagnosis is made, the greater the potential for reversibility. The chest radiographs and CT scans of 10 patients with thoracic locations of PTLD were reviewed. Mediastinal (n = 3) and hilar adenopathy (n = 2), pulmonary nodules (n = 8), and pleural thickening or effusion (n = 4) were encountered. The incidence of partial resolution with clinical remission (n = 4) appears to be noteworthy, and in all likelihood is related to the extensive necrosis (n = 5) that is frequently seen. Slow regression, transitory deterioration in one case, and localization only on the graft side in two cases, were observed. These morphological and evolutionary peculiarities must be known in order to optimize the diagnosis, and thus the prognosis, of these very original disorders.
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