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  • 1
    facet.materialart.
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  48. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 55. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie, 22. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20170914-20170916; Graz, Österreich; DOC017 /20170816/
    Publication Date: 2017-08-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    facet.materialart.
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  46. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 20. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20151001-20151003; Berlin; DOC173 /20150928/
    Publication Date: 2015-09-29
    Keywords: bariatric surgery ; abdominoplasty ; intra- and postoperative complications ; retrospective ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
    facet.materialart.
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  48. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 55. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie, 22. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20170914-20170916; Graz, Österreich; DOC050 /20170816/
    Publication Date: 2017-08-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
    facet.materialart.
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  48. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 55. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie, 22. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20170914-20170916; Graz, Österreich; DOC045 /20170816/
    Publication Date: 2017-08-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    facet.materialart.
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  46. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 20. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20151001-20151003; Berlin; DOC226 /20150928/
    Publication Date: 2015-09-29
    Keywords: Mammareduktionsplastik ; Komplikationen ; Clavien-Dindo-Klassifikation ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
    facet.materialart.
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  45. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 19. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC), 52. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie (ÖGPRÄC); 20140911-20140913; München; DOC236 /20140903/
    Publication Date: 2014-09-04
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 7
    ISSN: 1432-1912
    Keywords: 3H-Catecholamines ; Perfused rat heart ; Stereoselectivity ; Extraneuronal O-methylating system ; Catechol-O-methyl transferase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a comparative study, the handling of five catecholamines by the extraneuronal O-methylating system of the rat heart was determined; all rats were pretreated with reserpine, monoamine oxidase and neuronal uptake were inhibited in all experiments. 1. Hearts were perfused for 7 min with a tracer concentration of 3H-(±)-isoprenaline, either in the absence or in the presence of unlabelled catecholamines (which reduced the O-methylation of the tracer amine). IC50's were determined for unlabelled catecholamines and then converted to “half-saturating outside concentrations”, i.e., to those concentrations in the perfusion fluid that halfsaturate the intracellular catechol-O-methyl transferase (COMT). The values for the (-)-isomers of dobutamine, isoprenaline, adrenaline and noradrenaline and that for dopamine were low and rather similar (between 0.67 and 2.7 μmol/l). Stereoselectivity for isoprenaline probably reflected the preference of uptake2 for the (-)-isomer. 2. The effects of (-)- and (+)-dobutamine indicated that both isomers are a) transported by uptake2 and b) good substrates of COMT. 3. The V max for O-methylation [determined for 3H-(±)-isoprenalina, 3H-(±)-adrenaline, 3H-(±)-noradrenaline and 3H-dopamine] was rather similar for all four catecholamines. 4. It is concluded that the extraneuronal O-methylating system of the rat heart handles the five catecholamines in a similar manner, although the K m for uptake2 had been found to increase substantially in the order: dobutamine 〈 isoprenaline 〈 adrenaline 〈 noradrenaline 〈 dopamine (Grohmann and Trendelenburg 1984b).
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  • 8
    ISSN: 1432-1912
    Keywords: Neuronal deamination ; Extraneuronal deamination ; Isotope effects ; 3H-catecholamides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The neuronal and extraneuronal disposition of3H-7,8-and3H-7-labelled (−)-noradrenaline and dopamine was compared in in vitro studies. 1. In agreement with earlier studies, the present results show that the presence of a tritium label in position 8 (i.e., on the alpha-carbon) has two consequences: a) the rate of deamination declines and b) part of the deamination results in the formation of an unlabelled aldehyde plus tritium water; tritium water is recovered from the OMDA-fraction of the column chromatographic procedure of Graefe et al. (1973). 2. Whenever the deamination of a3H-catecholamine is reduced (by tritium in position 8), the intraneuronal3H-catecholamine concentration is increased. This increase, in turn, partly masks the decline in neuronal deamination (rat vas deferens). Irrespective of whether one dertermines the spontaneous efflux, the release of3H-noradrenaline by nerve stimulation or the release of3H-(−)-noradrenaline by the reserpine-like compound Ro 4-1284, the presence of tritium in position 8 distorts the results (experiments with rat vasa deferentia and/or rabbit aorta). 3. In the extraneuronal system of the rat heart, two intracellular enzymes inactivate3H-(−)-noradrenaline and3H-dopamine: catechol-O-methyl transferase (COMT) and monoamine oxidase (MAO). Any hindrance of deamination (by tritium in position 8, COMT intact) leads to a shift of the metabolism of the3H-catecholamines from the exclusively deaminated to the exclusively O-methylated metabolites. 4. No differences between3H-7,8-and3H-7-labelled catecholamines were found after inhibition of MAO and COMT (extraneuronal accumulation and rate constant for efflux from the extraneuronal compartment III of the rat heart). 5. These results indicate that the presence of tritium in position 8 of catecholamines introduces errors, if monoamine oxidase is active. This is important for the interpretation of earlier results, since virtually all samples of “3H-(−)-noradrenaline” and “3H-dopamine nominally labelled in position 7” were contaminated with varying amounts of tritium in position 8. 6. In some experiments, also3H-7-(−)-adrenaline was used. For adrenergic nerve endings, the rate of metabolism (deamination) declined in the order:3H-7-dopamine 〉 3H-7-(−)-noradrenaline 〉 3H-7-(−)-adrenaline. For the extraneuronal disposition the ranking order was:3H-7-(−)-adrenaline 〉 3H-7-(−)-noradrenaline=3H-7-dopamine. However, in the extraneuronal disposition of3H-(−)-adrenaline, O-methylation predominated over deamination.
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  • 9
    ISSN: 1432-1912
    Keywords: 3H-catecholamines ; Neuronal deamination ; Extraneuronal deamination ; Extraneuronal O-methylation ; k enzyme rat heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a comparative study the neuronal and extraneuronal metabolism of several 3H-catecholamines (all of which were tritiated in the C-7 position of the side chain only) was determined in isolated rat hearts perfused at a concentration of the 3H-amines of 50 nmol/1. While the neuronal MAO activity was determined after inhibition of extraneuronal uptake (100 μmol/1 OMI) and COMT (10 μmol/1 U-0521), the extraneuronal MAO activity was estimated after inhibition of neuronal uptake (30 μmol/1 cocaine) and COMT. The extraneuronal COMT activity was determined under conditions of inhibition of both neuronal uptake and MAO (pretreatment with pargyline). Hearts were perfused with the 3H-catecholamines until the rate of appearance of the various 3H-metabolites in the venous effluent has reached a steady state. From these rates (v st-st) and the steady-state content of the unchanged 3H-catecholamines in the tissue (S i), the rate constants (V max/K m) for the unsaturated intracellular enzymes COMT (κCOMT) and MAO (κMAO) were calculated. The κCOMTvalues for all four catecholamines, (−)-noradrenaline, dopamine, (−)-adrenaline and (±)-isoprenaline exhibit a range from 0.24 to 0.78 min−1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine 〈 (−)-adrenaline 〈 (±)-isoprenaline. The extraneuronal MAO activity was low for all three catecholamines, (−)-adrenaline, (−)-noradrenaline and dopamine (range of κMAOfrom 0.05 to 0.28 min−1) and declined in the order: (−)-adrenaline 〈 (−)-noradrenaline 〈 dopamine. The neuronal MAO activity for (−)-adrenaline, (−)-noradrenaline and dopamine was slightly higher than that in the extraneuronal cells (range of kMAO from 0.08 to 0.35 min−1), but the ranking order showed the same pattern: (−)-adrenaline 〈 (−)-noradrenaline = dopamine.
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  • 10
    ISSN: 1432-1912
    Keywords: Extraneuronal monoamine oxidase ; Uptake2 ; Rat heart ; Extraneuronal deaminating system ; Catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The handling of five amines by the extraneuronal deaminating system was studied in perfused hearts of rats (pretreated with reserpine; COMT and neuronal uptake inhibited). Hearts were perfused with 50 nmol/l 3H-noradrenaline for 30 min, in the presence of increasing concentrations of unlabelled (−)-adrenaline, (−)-noradrenaline, dopamine, tyramine and 5-HT. IC50's were determined as those concentrations of unlabelled amines which halved the steady-state rate of deamination of 3H-noradrenaline. After correction for changes in the tissue/medium ratio for 3H-noradrenaline, “half-saturating outside concentrations” were obtained. They increased in the order (−)-adrenaline (15 μmol/l) — tyramine — dopamine — noradrenaline —5-HT (53 μmol/l). The V max for extraneuronal deamination was determined for 3H-(−)-adrenaline, 3H-(−)-noradrenaline and 3H-dopamine, as well as (by HPLC and electrochemical detection) for tyramine and 5-HT. It was low for (−)-adrenaline, intermediate for (−)-noradrenaline, dopamine and 5-HT, high for tyramine. For the three catecholamines the half-saturating outside concentrations of the extraneuronal deaminating system clearly exceeded those for the extraneuronal O-methylating system of the same organ (see Grohmann and Trendelenburg 1985), although the two enzymes appear to co-exist in the same cells, so that the same transport system is involved.
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