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  • 1
    Call number: QZ200:530/12(4) ; QZ340WW101:49(4) ; M110:26
    Keywords: Eye Neoplasms ; Eye Neoplasms / classification
    Notes: The WHO Classification of skin tumours presented in this book reflects the views of a Working Group that convened for a Consensus and Editorial Meeting at the International Agency for Research on Cancer, Lyon 11-13 January 2018.
    Pages: 223 p. : ill.
    Edition: 4th. ed.
    ISBN: 9789283244974
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    QZ200:530/12(4) available
    QZ340WW101:49(4) available
    M110:26 departmental collection or stack – please contact the library
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  • 2
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bilateral serous retinal detachments are rare complications of thrombotic thrombocytopenic purpura (TTP). We report the case of a 28-year-old woman with chronic relapsing TTP with bilateral serous retinal detachments, which resolved after prompt aggressive medical therapy. Unlike serveral previous reports, the retinal detachments in our patient were unrelated to systemic hypertension.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0851
    Keywords: Key words Drug therapy ; T cells ; Apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Noscapine, a phthalideisoquinoline alkaloid derived from opium, has been used as an oral anti-tussive agent and has shown very few toxic effects in animals or humans. Recently, we reported that noscapine binds stoichiometrically to tubulin and promotes microtubule polymerization. Noscapine causes growth arrest of tumor cells in mitosis and induces apoptosis of tumor cells in vitro. Previous experiments also showed that noscapine has potent antitumor activity in mice when administered parenterally or by gastric lavage. Here, we report that the anti-mitotic effect was specific to noscapine since closely related compounds did not inhibit the growth of a lymphoma cell line. In addition, noscapine was shown to be effective in reducing the growth of the lymphoma and increasing the survival of tumor-bearing mice when administered in the drinking water. It is noteworthy that, noscapine showed little or no toxicity to kidney, liver, heart, bone marrow, spleen or small intestine at tumor-suppressive doses. Furthermore, oral noscapine did not inhibit primary immune responses, which are critically dependent upon proliferation of lymphoid cells. Thus, our results indicate that noscapine has the potential to be an effective chemotherapeutic agent for the treatment of human cancer.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2630
    Keywords: cornea ; conjunctiva ; enucleation ; eyelid ; incidence ; lacrimal gland ; lens ; optic nerve ; pathology ; uvea ; vitreous
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: To summarize the pathologic diagnoses of a large number of surgically-obtained specimens over an extended time period in a single ophthalmic pathology laboratory. Methods: We analyzed the records of 24,444 surgically obtained specimens accessioned in the L.F. Montgomery Ophthalmic Pathology Laboratory, Emory University, Atlanta, GA between May 1941 and December 1995. Age, sex, topography,clinical procedure, and histologic diagnosis were entered into a database using the modified SNOMED coding system. The diagnosis of the surgically enucleated eyes were analyzed with respect to years of enucleation. Results: The most common topographic area associated with a histologic diagnosis was the cornea (39.3%), followed by lens (16.0%), vitreous (12.0%),uvea (9.8%), eyelids (8.0%), conjunctiva(7.7%), retina (7.7%), and orbit(2.1%). The relative proportion of vitreous specimens has continuously increased and became the most common surgical specimen in 1995. The most common underlying disease of surgically enucleated eyes is trauma (40.9%), followed by ocular neoplasia (24.2%), ‘surgical‘ diseases of the cornea,lens and retina including glaucoma (17.3%), vascular diseases(6.7%), and inflammatory conditions (6.7%). The relative frequency of trauma and ocular inflammation as a cause of enucleation decreased significantly (p < 0.05) over the time of the study period while the relative proportion of ocular neoplastic processes increased (p < 0.0001).Conclusions: The availability of new surgical techniques has caused a change in the relative frequencies of different ocular specimens submitted for histologic examination.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1433-0423
    Keywords: Key words Age-related macular degeneration • Basal laminar deposit • Bruch's membrane • Drusen • Histology ; Schlüsselwörter Altersabhängige Makuladegeneration • Basal laminar deposit • Bruch-Membran • Drusen • Histologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Hintergrund: Unterschiedliche Drusenarten sowie Veränderungen der Bruch-Membran wurden in der Vergangenheit häufig mit der altersabhängigen Makuladegeneration (AMD) assoziiert. Material und Methode: Wir verglichen lichtmikroskopisch 51 Augen mit unterschiedlichen Stadien der altersabhängigen Makuladegeneration mit 40 Augen ohne AMD. Der Grad der Kalzifikation sowie die Fragmentierung der Bruch-Membran und die Anzahl der verschiedenen Drusenarten einschließlich „basal laminar deposit“ (BLD) wurden bestimmt. Ergebnisse: Im Bereich der Makula zeigten Augen mit AMD einen signifikant höheren Grad an BLD im Vergleich zu Augen ohne AMD. Zusätzlich fanden sich bei Augen mit AMD – insbesondere bei Augen mit der exsudativen Form der AMD – deutlich mehr Kalzifikationen sowie Fragmentierungen der Bruch-Membran im Vergleich mit Augen ohne AMD. Augen mit AMD wiesen signifikant mehr weiche, konfluierende und große Drusen auf im Vergleich mit Augen ohne AMD. Schlußfolgerungen: Die Anzahl von weichen, konfluierenden und großen Drusen sowie der Grad an „basal laminar deposit“ korrelierten mit dem histologischen Vorhandensein einer altersabhängigen Makuladegeneration. Harte Drusen hingegen scheinen keinen Risikofaktor für die Entwicklung einer AMD zu bedeuten. Veränderungen der Bruch-Membran im Sinn von Kalzifikationen und Fragmentierungen scheinen für die Entwicklung der exsudativen Form der AMD zu prädisponieren.
    Notes: Background: Different types of drusen and changes in Bruch's membrane have been associated with age-related macular degeneration (AMD). Methods: We compared 51 eyes with different stages of AMD with 40 age-matched controls using light microscopy. The degree of calcification of Bruch's membrane, fragmentation of Bruch's membrane, number of different types of drusen, and basal laminar deposit (BLD) were assessed. Results: In the macular area, the presence of basal laminar deposit was most strongly associated with the presence of AMD. There was a statistically significant difference observed in the degree of calcification and fragmentation of Bruch's membrane in eyes with AMD as compared to controls. Eyes with AMD displayed significantly more soft, confluent, and large drusen as compared to controls. Conclusion: Calcification and fragmentation of Bruch's membrane, soft, confluent, and large drusen and BLD but not hard drusen correlated strongly with the histologic presence of AMD. Calcification and fragmentation of Bruch's membrane seem to facilitate ingrowth of choroidal neovascular membranes with consecutive development of exudative AMD.
    Type of Medium: Electronic Resource
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