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  • 1
    Publication Date: 2011-04-08
    Description: Regulatory mechanisms governing the sequence from progenitor cell proliferation to neuronal migration during corticogenesis are poorly understood. Here we report that phosphorylation of DISC1, a major susceptibility factor for several mental disorders, acts as a molecular switch from maintaining proliferation of mitotic progenitor cells to activating migration of postmitotic neurons in mice. Unphosphorylated DISC1 regulates canonical Wnt signalling via an interaction with GSK3beta, whereas specific phosphorylation at serine 710 (S710) triggers the recruitment of Bardet-Biedl syndrome (BBS) proteins to the centrosome. In support of this model, loss of BBS1 leads to defects in migration, but not proliferation, whereas DISC1 knockdown leads to deficits in both. A phospho-dead mutant can only rescue proliferation, whereas a phospho-mimic mutant rescues exclusively migration defects. These data highlight a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088774/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088774/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ishizuka, Koko -- Kamiya, Atsushi -- Oh, Edwin C -- Kanki, Hiroaki -- Seshadri, Saurav -- Robinson, Jon F -- Murdoch, Hannah -- Dunlop, Allan J -- Kubo, Ken-ichiro -- Furukori, Keiko -- Huang, Beverly -- Zeledon, Mariela -- Hayashi-Takagi, Akiko -- Okano, Hideyuki -- Nakajima, Kazunori -- Houslay, Miles D -- Katsanis, Nicholas -- Sawa, Akira -- DK-072301/DK/NIDDK NIH HHS/ -- DK-075972/DK/NIDDK NIH HHS/ -- G0600765/Medical Research Council/United Kingdom -- HD-04260/HD/NICHD NIH HHS/ -- MH-069853/MH/NIMH NIH HHS/ -- MH-084018/MH/NIMH NIH HHS/ -- MH-085226/MH/NIMH NIH HHS/ -- MH-088753/MH/NIMH NIH HHS/ -- MH-091230/MH/NIMH NIH HHS/ -- R01 DK072301/DK/NIDDK NIH HHS/ -- R01 DK075972/DK/NIDDK NIH HHS/ -- R01 DK075972-06/DK/NIDDK NIH HHS/ -- R01 HD042601/HD/NICHD NIH HHS/ -- R01 HD042601-10/HD/NICHD NIH HHS/ -- R01 MH091230/MH/NIMH NIH HHS/ -- R01 MH092443/MH/NIMH NIH HHS/ -- England -- Nature. 2011 May 5;473(7345):92-6. doi: 10.1038/nature09859. Epub 2011 Apr 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21471969" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; COS Cells ; Cell Movement/genetics ; Cell Proliferation ; Cercopithecus aethiops ; Cerebral Cortex/cytology/*embryology/physiology ; Gene Knockdown Techniques ; Glycogen Synthase Kinase 3/metabolism ; HEK293 Cells ; Humans ; Mice ; Microtubule-Associated Proteins/genetics/metabolism ; *Nerve Tissue Proteins/genetics/metabolism ; Neurons/*cytology/metabolism/*physiology ; PC12 Cells ; Phosphorylation ; Protein Binding ; Rats ; Signal Transduction ; Stem Cells/*cytology ; Wnt Proteins/metabolism ; beta Catenin/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    ISSN: 1573-5117
    Keywords: DOC ; bacteria ; fungi ; respiration ; Gammarus tigrinus ; Tipula caloptera ; biofilms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Glass-beads (diam. = 250 µm) were buried 10 cm deep in the sediment of a stream. After an exposure of eight weeks, bacterial densities on the beads varied between 2.7 × 105 and 2.4 × 107/cm2, and the length of the fungal mycelium between 0.2 and 5.3 mm/cm2. Bacterial densities did not show any correlation with the DOC content of the water, but were positively correlated with respiration on the beads. Fungal mycelium was negatively correlated with water temperature. Acid hydrolysis of stream-exposed beads released sugars and amino acids, whose combined carbon content exceeded that of the microbial cells by a factor of at least 4. Gut extracts of Gammarus tigrinus and Tipula caloptera released amino acids and sugars from stream-exposed beads.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The spectrum of the highest redshift QSO 2000−330 (z=3.78) contains four heavy-element absorption systems withz abs〉3.0. Interesting features include velocity structure atz abs=3.552 which suggests a cluster origin and a purely low ionization system atz abs=3.1881 typical of a galactic disk sightline.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Complex velocity structure is revealed in several absorption systems in the spectrum of 0215+015 (z=1.715) at resolutions of 20–30 km s−1 FWHM. Striking differences are found in the relative strengths of low to high ions among the components, reinforcing our interpretation of these systems as intervening galaxies.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 45 (1962), S. 1156-1161 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The preparation of two new π-olefin complexes, butadiene iron tetracarbonyl and butadiene di-iron octacarbonyl, is described and their structures are discussed. Butadiene iron tetracarbonyl adds hydrogen chloride with formation of an unstable cationic complex which decomposes easily, especially in polar solvents, with formation of π-methallyl iron tricarbonyl chloride.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 45 (1962), S. 1927-1933 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A general method for the synthesis of π-allyl-iron-tricarbonyl halides, enabling the preparation of the parent π-allyl complexes and also of π-allyl complexes with functional groups attached to the allyl ligand, is described. The method is equally applicable to the preparation of the chlorides, bromides and iodides. A series of such compounds have been prepared, and their physical properties and structures are discussed.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 47 (1964), S. 1517-1524 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reductive dehalogenation of halo-π-allyl-tricarbonyliron complexes affords bis-(π-allyl-tricarbonyliron) which coexists in solution with the paramagnetic π-allyl-tricarbonyliron. Similar paramagnetic complexes have also been obtained with substituted π-ally1 ligands and also with both one or two of the carbonyl groups replaced by t-phosphines. The elucidation of the structure of these products, based on analytical, electron spin resonance, and infrared data, is discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: From theoretical considerations, it can be predicted that electron-withdrawing substituents on an olefin will stabilize the π-bond formed by the latter with zerovalent transition metals in complexes such as π-olefin iron tetracarbonyl. In agreement with this iron tetracarbonyl complexes have been prepared with ligands such as maleic, fumaric, citraconic, acrylic, methacrylic and cinnarnic acids and their derivatives. The structures of these compounds have been confirmed by analytical, IR and NMR data.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 46 (1963), S. 1588-1594 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reactions of ethylene and hexatriene with di-iron enneacarbonyl give π-ethylene iron tetracarbonyl, and π-hexatriene iron tricarbonyl, π-hexatriene di-iron octacarbonyl, π-hexatriene di-iron heptacarbonyl, and π-hexatriene iron tetracarbonyl respectively. The compounds with the exception of the latter were isolated and characterised. Their structures are discussed on the basis of Ir.-, NMR.- and dipole moment data.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 47 (1964), S. 936-941 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reactions of allylic diols or allylic chloro-alcohols with di-iron-enneacarbonyl give, by elimination of water or HCL, π-allyl-acyl-iron-tricarbonyl complexes. The structures of these products are discussed on the basis of spectroscopic and chemical studies.
    Type of Medium: Electronic Resource
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