Description / Table of Contents:
Imaging Platforms and Drug Development:℗ An Introduction -- Imaging in Drug Development: Animal Models, Handling and Physiological Constraints -- Considerations for Pre-Clinical Laboratory Animal Imaging Center Design, Setup, and Management suitable for Biomedical Investigation for Drug Discovery -- Pharmaco-Imaging in Translational Science and Research -- The Role of Pharmacokinetics and Allometrics in Imaging: Practical Issues and Considerations -- Quantitative Imaging Using Autoradiographic Techniques -- Pre-Clinical Imaging in Oncology: Considerations and Recommendations for the Imaging Scientist -- Use of Radiolabelled Leukocytes for Drug Evaluation in Man -- Application of Bioluminescence Imaging (BLI) to the Study of the Animal Models of Human Infectious Diseases -- Pre-Clinical Imaging in BSL-3 and BSL-4 Environments:℗ Imaging Pathophysiology of Highly Pathogenic Infectious Diseases -- Magnetic Resonance as a Tool for Pharmaco-Imaging -- Technologies and Principles of Mass Spectral Imaging -- Regulatory Considerations Involved In Imaging
Advances in drugs and biologics to mitigate or cure some of naturé€™s most complex medical problems have been incredible to behold.℗ These accomplishments are due to the actions of a wide theatre of participants from biologists, pharmacologists, geneticists, chemists and manufacturers, molecular biologists, toxicologists, clinicians, nurses, program managers, quality assurance personnel, regulatory professionals and ́€” a new group of innovators ́€” the Imaging Scientists.℗ Imaging has grown from the microscopy sections put on slides with special stains to now in vivo ́€œsliceś€ created with innovative physics, imaging tracers and contrast agents, and incredibly fast and accurate computational systems.℗ The world of biology has become one of witnessing the actions of drugs and biologics through the window of mechanical and electrical engineering ́€” creating℗ instruments and reporter molecules that can help us ́€œseé€ into our bodies and ́€œpaint́€ them with medical information needed to resolve disease. This book will inspire imagination and elicit even more innovations in the development of new and novel drugs and biologics through imaging
XVII, 401 p. 125 illus., 101 illus. in color. : online resource.