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  • 1
    Keywords: Medicine ; Cancer Research ; Cell Biology ; Biomedicine ; Cancer Research ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Chap. 1 The Dawning of Translational Breast Cancer: from Bench to Bedside -- Chap. 2 Biomarker Studies in Early Detection and Prognosis of Breast Cancer -- Chap. 3 The Preventive Intervention of Hereditary Breast Cancer -- Chap. 4 Predicting and Overcoming Chemotherapeutic Resistance for Breast Cancer -- Chap. 5 Studies on DNA Damage Repair and Precision Radiotherapy for Breast Cancer -- Chap. 6 Targeted Therapies against Growth Factor Signaling in Breast Cancer -- Chap. 7 Targeting Stemness: Implications for Precision Medicine in Breast Cancer -- Chap. 8 Disrupting Tumor Angiogenesis and “the Hunger Games” for Breast Cancer -- Chap. 9 Key Factors in Breast Cancer Dissemination and Establishment at the Bone: Past, Present and Future Perspectives -- Chap. 10 Perspectives of Reprogramming Breast Cancer Metabolism -- Chap. 11 Metabolic Changes during Cancer Cachexia Pathogenesis -- Chap. 12 Cell Cycle Regulation in Treatment of Breast Cancer -- Chap. 13 BRCA Gene Mutations and Poly (ADP-ribose) Polymerase Inhibitors in Triple-negative Breast Cancer -- Chap. 14 Targeting the Epigenome as a Novel Therapeutic Approach for Breast Cancer -- Chap. 15 Progress in Vaccine Therapies for Breast Cancer -- Chap. 16 Tumor Associated Macrophages as Therapeutic Targets for Breast Cancer -- Chap 17 New Approaches in CAR-T Cell Immunotherapy for Breast Cancer -- Chap 18 Immune Checkpoint Blockade in Breast Cancer Therapy
    Abstract: This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. ℗ With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. ℗ ℗ As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research. ℗
    Pages: VIII, 418 p. 15 illus. in color. : online resource.
    ISBN: 9789811060205
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  • 2
    Dordrecht : Springer Science+Business Media
    Keywords: Medicine ; Oncology ; Cell receptors ; Cytokines ; Cytology ; Biomedicine ; Cancer Research ; Molecular Medicine ; Cytokines and Growth Factors ; Receptors ; Cell Biology ; Springer eBooks
    Pages: : digital
    ISBN: 9789048195220
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  • 3
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Biomedicine general ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: Imaging Platforms and Drug Development:℗ An Introduction -- Imaging in Drug Development: Animal Models, Handling and Physiological Constraints -- Considerations for Pre-Clinical Laboratory Animal Imaging Center Design, Setup, and Management suitable for Biomedical Investigation for Drug Discovery -- Pharmaco-Imaging in Translational Science and Research -- The Role of Pharmacokinetics and Allometrics in Imaging: Practical Issues and Considerations -- Quantitative Imaging Using Autoradiographic Techniques -- Pre-Clinical Imaging in Oncology: Considerations and Recommendations for the Imaging Scientist -- Use of Radiolabelled Leukocytes for Drug Evaluation in Man -- Application of Bioluminescence Imaging (BLI) to the Study of the Animal Models of Human Infectious Diseases -- Pre-Clinical Imaging in BSL-3 and BSL-4 Environments:℗ Imaging Pathophysiology of Highly Pathogenic Infectious Diseases -- Magnetic Resonance as a Tool for Pharmaco-Imaging -- Technologies and Principles of Mass Spectral Imaging -- Regulatory Considerations Involved In Imaging
    Abstract: Advances in drugs and biologics to mitigate or cure some of natur這s most complex medical problems have been incredible to behold.℗ These accomplishments are due to the actions of a wide theatre of participants from biologists, pharmacologists, geneticists, chemists and manufacturers, molecular biologists, toxicologists, clinicians, nurses, program managers, quality assurance personnel, regulatory professionals and ́€” a new group of innovators ́€” the Imaging Scientists.℗ Imaging has grown from the microscopy sections put on slides with special stains to now in vivo ́€œsliceś€ created with innovative physics, imaging tracers and contrast agents, and incredibly fast and accurate computational systems.℗ The world of biology has become one of witnessing the actions of drugs and biologics through the window of mechanical and electrical engineering ́€” creating℗ instruments and reporter molecules that can help us ́€œse逝 into our bodies and ́€œpaint́€ them with medical information needed to resolve disease. This book will inspire imagination and elicit even more innovations in the development of new and novel drugs and biologics through imaging
    Pages: XVII, 401 p. 125 illus., 101 illus. in color. : online resource.
    ISBN: 9781461482475
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  • 4
    Call number: C060:77
    Keywords: Random Allocation ; Clinical Trials
    Pages: xiii, 218 p. : ill.
    ISBN: 9780471653967
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    C060:77 departmental collection or stack – please contact the library
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  • 5
    Keywords: Biomedical Engineering ; Medical records / Data processing ; Biomedical Engineering/Biotechnology ; Health Informatics ; Health Informatics ; Biomedical Engineering and Bioengineering ; Springer eBooks
    Description / Table of Contents: 1. A literature Review of Social Media-based Data Mining for Health Outcomes Research -- 2. Social Media-Based Health Interventions: Where Are We Now? -- 3. Quantifying and Visualizing the Research Status of Social Media & Health Research Field -- 4. Social Media in Health Communication -- 5. Consumers' Selection of Sources in Searching for Health Information -- 6. Understanding and Bridging the Language and Terminology Gap between Health Professionals and Consumers using Social Media -- 7. Dissemination of Information on Stigmatized Health Issues on Social Media -- 8. Learning Wellness Profiles of Users on Social Networks: The Case of Diabetes -- 9. Social Media and Psychological Disorder -- 10. Content Analysis of the 2015 #SmearForSmear Campaign Using Deep Learning -- 11. How to Improve Public Health via Mining Social Media Platforms: A Case Study of Human Papillomaviruses (HPV) -- 12. Learning Hormonal Therapy Medication Adherence from an Online Breast Cancer Forum -- 13. Ethics in Health Research using Social Media
    Abstract: This book presents state-of-the-art research methods, results, and applications in social media and health research. It aims to help readers better understand the different aspects of using social web platforms in health research. Throughout the chapters, the benefits, limitations, and best practices of using a variety of social web platforms in health research are discussed with concrete use cases. This is an ideal book for biomedical researchers, clinicians, and health consumers (including patients) who are interested in learning how social web platforms impact health and healthcare research
    Pages: XIII, 272 p. 31 illus., 19 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030147143
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  • 6
    Keywords: Medicine ; Emerging infectious diseases ; Oncology ; Pathology ; Medicine & Public Health ; Pathology ; Molecular Medicine ; Oncology ; Infectious Diseases ; Health Promotion and Disease Prevention ; Springer eBooks
    ISBN: 9781461421702
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  • 7
    Cambridge, MA : Academic Press/Elsevier
    (The enzymes, vol. 42)  
    Call number: B200:3
    Pages: xvi, 172 p. : ill.
    ISBN: 9780128126387
    Signatur Availability
    B200:3 departmental collection or stack – please contact the library
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  • 8
    Keywords: Biochemistry ; Protein Science ; Springer eBooks
    Description / Table of Contents: Nitrogenases -- Bacteriochlorophyll and Coenzyme F430 -- Carbon Monoxide Dehydrogenases -- Molybdenum-Containing Enzymes -- Hydrogenases -- Genomic Manipulations of the Diazotroph Azotobacter vinelandii -- Purification of Nitrogenase Proteins -- Expression, Purification and Activity Analysis of Chlorophyllide Oxidoreductase and Ni2+-Sirohydrochlorin a,c-Diamide Reductase -- Reconstitution of Molybdoenzymes with Bis-Molybdopterin Guanine Dinucleotide Cofactor -- Crystallization of Nitrogenase Proteins -- X-Ray Crystallography of Carbon Monoxide Dehydrogenases -- X-Ray Absorption Spectroscopy of Metalloproteins -- Electron Paramagnetic Resonance Spectroscopy of Metalloproteins -- Magnetic Circular Dichroism Spectroscopy of Metalloproteins -- Chemical Synthesis of an Asymmetric Mimic of the Nitrogenase Active Site -- Computational Methods for Modeling Metalloproteins
    Abstract: This volume provides an up-to-date, in-depth overview of the methods that have been applied to studying the complex metalloproteins at a molecular level. Chapters cover a wide range of approaches focusing on genetic, biochemical, spectroscopic, chemical methods, and theoretical calculations. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metalloproteins: Methods and Protocols aims to be useful for anyone who is interested in metalloprotein research and wants to address the unanswered mechanistic and biosynthetic questions of these fascinating enzyme systems
    Pages: X, 275 p. 62 illus., 40 illus. in color. : online resource.
    ISBN: 9781493988648
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  • 9
    Call number: YY Diss Nick/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 69 p.
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    YY Diss Nick/Mag departmental collection or stack – please contact the library
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  • 10
    Publication Date: 2018-05-02
    Description: p21WAF1/CIP1 is a broad-acting cyclin-dependent kinase inhibitor. Its stability is essential for proper cell-cycle progression and cell fate decision. Ubiquitylation by the multiple E3 ubiquitin ligase complexes is the major regulatory mechanism of p21, which induces p21 degradation. However, it is unclear whether ubiquitylated p21 can be recycled. In this...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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