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  • 1
    Keywords: CANCER ; tumor ; CELL ; Germany ; liver ; SAMPLE ; SAMPLES ; TISSUE ; TUMORS ; SURGERY ; PATIENT ; IMPACT ; ACID ; ACIDS ; MALIGNANCIES ; PATTERNS ; PLASMA ; AGE ; GAS ; fatty acids ; DIET ; IMPROVES ; SMALL-INTESTINE ; nutrition ; COMPLICATIONS ; FATTY-ACID ; MALIGNANCY ; PATTERN ; FRACTION ; LEADS ; PHOSPHOLIPIDS ; WEIGHT ; SUPPLEMENTATION ; TUMOR TISSUE ; LEVEL ; methods ; PLASMA-LEVELS ; TISSUE SAMPLES ; USA ; phospholipid ; uptake ; EICOSAPENTAENOIC ACID ; ENTERAL NUTRITION ; EVALUATE ; GUT ; IMMUNONUTRITION ; MAJOR SURGERY ; PARENTERAL FISH-OIL ; POSTOPERATIVE TRAUMA ; TREATED RATS
    Abstract: Background: The uptake of omega-3 polyunsaturated fatty acids (PUFAs) into the liver, gut mucosa, and tumor tissue and plasma levels after preoperative administration of supplemented enteral nutrition was investigated in patients with malignancies of the upper gastrointestinal tract. The objective of the study was to evaluate the incorporation of preoperatively administrated PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) into cell phospholipids. Methods: Patients undergoing major gastrointestinal surgery (n = 40) were prospectively randomized to receive a PUFA-supplemented liquid oral diet 5 days preoperatively or an isocaloric control diet. The planned diet intake was 1000 mL/d providing 3.7 g of PUFA. The diet was given in addition to the usual hospital diet. The phospholipid fractions in plasma were analyzed on the day of surgery. Tissue samples of liver, gut mucosa (small intestine), and tumor were taken during surgery and homogenized. EPA and DHA content was analyzed using liquid gas chromatography. Results: Both patient groups (PUFA group: n = 20; control group: n = 20) were similar in age, weight, and surgical procedures. As compared with the control group, the PUFA group had significantly increased levels of EPA in liver tissue (0.4 vs 1.3 weight %), gut mucosa (0.3 vs 1.0 weight %), and tumor tissue (0.3 vs 0.8 weight %). Also, the DHA levels in the PUFA group were significantly higher than the control group: liver tissue (4.1 vs 7.5 weight %), gut mucosa (2.1 vs 3.7 weight %) and tumor tissue (1.9 vs 4.2 weight %). Conclusions: This study suggests that administration of PUFA-enriched diets leads to increased incorporation of EPA and DHA not only in liver and gut mucosa tissue, but also in tumor tissue in patients with solid gastrointestinal tumors. Thus, preoperative administration of oral PUFA-enriched diets could have an impact on the postoperative inflammatory response after major abdominal surgery
    Type of Publication: Journal article published
    PubMed ID: 15961678
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20031111-20031116; Berlin; DOC03dguK8-12 /20031111/
    Publication Date: 2003-11-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  68. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 90. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 45. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20041019-20041023; Berlin; DOC04dguO22-1979 /20041019/
    Publication Date: 2004-10-20
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  68. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 90. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 45. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20041019-20041023; Berlin; DOC04dguJ2-1978 /20041019/
    Publication Date: 2004-10-20
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    ISSN: 1433-0466
    Keywords: Key words Local injection therapy • Manual medicine • Low back pain ; Schlüsselwörter Therapeutische Lokalanaesthesie • Manuelle Therapie • Pseudoradikuläre Wirbelsäulensyndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Am Beispiel einer 30-Betten-Station der Orthopädischen Universitätsklinik Bochum wird das Aufkommen an Verfahren der TLA den manualtherapeutischen Handgriffen im Zeitraum eines Jahres gegenübergestellt. Es handelt sich um 191 ISG-Injektionen sowie 28 Facettengelenkinjektionen an der HWS und 315 an der LWS. Demgegenüber standen 122 manualtherapeutische Handgriffe, durchgeführt an HWS, BWS und LWS durch die jeweiligen Stationsärzte mit abgeschlossener Weiterbildung. Während sich die TLA auf die Hauptprädilektionsstelle des jeweiligen Krankheitsbildes (pseudoradikuläre HWS- und LWS-Syndrome) konzentrierte, bezog sich die manuelle Therapie vorrangig auf Nebenbefunde in anderen Wirbelsäulenetagen bei Patienten mit den genannten Diagnosen oder mit Postdiskotomiesyndrom. Die zunehmende Ausbildung des ärztlichen Personals läßt einen Wandel hin zur manualtherapeutischen Behandlung auch der Hauptbefunde erwarten, wird jedoch die TLA nicht ersetzen.
    Notes: Summary In a 30-beds-unit of the Orthopedic University Clinic in Bochum for an example we studied the frequency of combined injection therapy with local anesthesia and chirotherapy in a one year period. There have been done 191 injections into ileosacral joints as well as 28 injections into facett joints of the cervical spine and additionally 315 into facett joints of the lumbar spine. On the other side there have been done 122 chirotherapeutic maneuvers at cervical, thoracic or lumbar spine by senior doctors with education in manual medicine. The injection therapy however was done in mean predilection sites of the patients suffering from cervical spine disorders or low back pain, the chirotherapy was done in other spine areas. The growing number of doctors with an education in manual medicine seems to improve the chirotherapy of the mean pathology as well, but it is not able to reduce the number of local injection therapy.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0932
    Keywords: Percutaneous discectomy ; Osteomyelitis ; Haematogenous spondylodiscitis ; Aspiration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lumbar disc infection, either after surgical discectomy or caused by haematogenous spread from other infection sources, is a severe complication. Specific antibiotic treatment has to be started as soon as possible to obtain satisfactory results in conservative treatment or operative fusion. The aim of this study was to analyse 16 cases of lumbar disc infection, treated with percutaneous lumbar discectomy (PLD) to obtain adequate amounts of tissue for histological examination and microbial culture. Between 1990 and 1994, 26 patients with vertebral osteomyelitis were treated. Sixteen patients, with an average age of 41.4 years (range 14–59 years), underwent a diagnostic PLD. Eight of them showed only moderate changes on computed tomograms (CT scans) and magnetic resonance (MR) images in the initial stages of the disease. The other eight showed more or less extensive osteolytic lesions of one or both vertebral bodies adjacent to the involved disc. The histology results showed non-specific discitis in nine patients and tuberculosis in one. In two patients an open biopsy had been performed, which showed non-specific discitis. Microbiological analysis revealed specific infection in 45% of the patients. These patients received a specific antibiotic treatment after antibiogram for an average of 33 days. Only three patients were treated surgically, with evacuation of the disc space and interbody fusion; the whole group received a spondylitis brace. All patients obtained satisfactory clinical results at the last follow-up regarding pain, mobility and spontaneous fusion of the involved disc space. In conclusion, PLD is a very helpful minimally invasive procedure in conservative treatment of lumbar discitis.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0932
    Keywords: Pedicle fixation ; Posterior spine surgery ; Lumbar spine ; Complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Medial or lateral pedicle screw penetration with the potential to affect neural structures in a well-known and frequent problem associated with posterior spinal fusion. We evaluated the placement of pedicle screws (n = 141) in 36 patients following posterior lumbar spinal fusion with Socon or Kluger instrumentation via a lateral transpedicular approach. The examination was based on CT and MR images performed after removal of the instrumentation, on average 1 year after implantation. We found seven pedicle screws with lateral cortical penetration of the pedicle and five screws with medial cortical penetration of the pedicle (8.5% pedicle penetration overall). No severe radicular complications accompanied these pedicle penetrations. The mean insertion angles of the pedicle screws at the L4 level were 22.6° and 23.1° for the left and the right side, respectively. At the L5 level the mean insertion angle was 20.5° on the left side and 21.5° on the right, and at the S1 level the mean angle was 16.2° on the left and 15.2° on the right. The results of this study indicate that the lateral transpedicular approach is a safe procedure for pedicle screw insertion.
    Type of Medium: Electronic Resource
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