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  • 1
    ISSN: 0942-0940
    Keywords: Haemangiopericytoma ; intracranial ; outcome ; proliferation indices ; p53
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cell proliferation indices of 31 primary intracranial haemangiopericytomas (HPC) and their recurrences and metastases were correlated with the long-term recurrence, metastasis and survival rates. Paraffin-embedded specimens were used for K-67, PCNA and p53 immunostainings and for estimation of S-phase fraction (S-PF) in flow cytometry. The median Ki-67 and PCNA indices and S-PFs were 10.4, 3.2, and 4.0 for primary HPCs and 14.1, 14.1, and 5.5 for recurrences, respectively. High indices were associated with higher recurrence, metastasis and death rates, but not at the p ≤ 0.5 level. Consequently, these indices do not seem useful in planning of treatment and follow-up of meningeal HPCs. Meningeal HPCs, in contrast to meningiomas, recur almost always despite seemingly complete removal and often metastasize elsewhere in the body. This difference between two sharply demarcated tumours must reflect particularly adhesive and infiltrative properties of HPC cells and not just higher proliferation potential.
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  • 2
    ISSN: 0942-0940
    Keywords: Keywords: Schwannoma; neurofibromatosis 2; comparative genomic hybridization.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ Background. Schwannomas occur sporadically or in association with neurofibromatosis 2 (NF2), an autosomal dominant disorder, which predisposes to multiple schwannomas, meningiomas and spinal ependymomas, with bilateral vestibular schwannomas as the classic hallmark. As NF2 and sporadic schwannomas differ in some respect in their clinical and biological behavior we evaluated whether there are any differences in the distribution of genetic aberrations between NF2 and sporadic schwannomas. Our interest was also to verify whether secondary genetic alterations besides the loss of 22q could be detected in schwannomas.  Methods. We investigated DNA copy number changes in 25 schwannomas (12 NF2 and 13 sporadic schwannomas) using the comparative genomic hybridization (CGH) technique. Some chromosomal regions were further studied by LOH or FISH analysis.  Findings. CGH detected genomic abnormalities in 15 of 25 schwannomas (60%). The most common alteration was loss on 22q, found in 32% (8/25) of schwannomas. No consistent changes were detected in other chromosomal regions. The overall number of genetic aberrations was similar in NF2 and in sporadic schwannomas.  Interpretation. Our results support the present view that loss of chromosome 22q harboring the NF2 gene plays a universal role in the pathogenesis of schwannomas without consistent involvement of other chromosomal regions.
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  • 3
    ISSN: 1432-0827
    Keywords: Bone mineral ; Dual energy x-ray absorptiometry ; Unilateral activity ; Squash ; Young women
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract We examined 19 female Finnish national level squash players and 19 healthy female controls with a dual energy x-ray absorptiometric (DXA) scanner for the determination of the association between long-term unilateral activity and bone mineral density (BMD) and content (BMC) of the upper extremities. In players, the BMDs and the BMCs were significantly higher in each bone site of the playing extremity. The side-to-side difference was largest in the proximal humerus (BMD 15.6%, BMC 17.8%) and smallest in the ulnar shaft (BMD 5.6%, BMC 7.3%). In sex-, age-, weight-, and height-matched controls, the side-to-side differences were significantly smaller, ranging from 1.6% to 4.1%. The number of training years and elbow flexion strength correlated positively with the relative BMD and BMC in the humerus of the playing arm (r=0.632–0.685). The starting age training in turn correlated negatively (r=-0.483 to-0.577) with these bone parameters. Significantly larger side-to-side differences (average 22%) were found in players who had started their career before or during menarche than in those who had begun the training 1 year or more after the menarche (9%). These findings suggest that the bones of the playing extremity clearly benefit from active squash playing. The benefit is largest in humerus and smaller in the bone of the forearm. The benefit of playing is stronger if the athlete has started the training at or before menarche than after it. Thus, physical activity seems to best enhance bone mineralization at childhood and puberty, the time when the natural rapid increase in bone mass also occurs.
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  • 4
    ISSN: 1434-0879
    Keywords: Superficial bladder cancer ; MIB-1 ; S-phase fraction ; M/V index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cell proliferation of transitional cell bladder cancer (TCC) was determined by MIB-1 immunolabeling, volume-corrected mitotic index (M/V index) and S-phase fraction measurement in 207 patients with superficial (Ta-T1) bladder cancer. The results were compared to T category, WHO grade and DNA-ploidy. The MIB-1 score was related to T category (P〈0.001), WHO grade (P〈0.001), DNA ploidy (P〈0.0001), M/V index (P〈0.0001) and fraction of cells in S phase (P〈0.0001). The mean MIB-1 score was 6.37% for G1, 14.59% for G2 and 28.59% for G3 carcinomas (P〈0.001). The MIB-1 score for Ta tumors was 9.24% and for T1 tumors 25.34% (P〈0.001). The M/V index was 3.9 for G1, 11.5 for G2 and 25.9 for G3 tumors (P〈0.0001). The M/V index for Ta tumors was 6.4 and 25.3 for T1 tumors (P〈0.0001). WHO grade 1 tumors had 7.7%, grade 2 tumors 13.8% and grade 3 tumors 21.8% of cells in S phase (P〈0.001). Of grade 1 tumors, 97% were diploid and 3% aneuploid, and 78% of grade 2 tumors were diploid and 22% aneuploid. Of grade 3 tumors, 30% were diploid and 70% aneuploid (P〈0.001). Of Ta tumors, 92% were diploid and 8% aneuploid, respectively, whereas 40% of T1 tumors were diploid and 60% aneuploid (P〈0.0001). The results show that quantitative cell proliferation indices are associated with T category and WHO grade in superficial bladder cancer. The prognostic value of the S-phase fraction and mitotic index has been demonstrated in several previous analyses of prognostic factors while the value of MIB-1 score on bladder cancer prognosis remains to be established in further follow-up studies.
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  • 5
    ISSN: 0942-0940
    Keywords: Keywords: Haemangioblastoma; von Hippel-Lindau disease; surgery; survival.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ The aim was to assess the frequency of von Hippel-Lindau disease (VHL) and the long-term prognosis of VHL and non-VHL patients among 110 consecutive patients with haemangioblastoma (HB) of the CNS treated between 1953 and 1993 at one neurosurgical unit.  To reveal VHL manifestations we performed a detailed clinical and radiological examination (neuraxis and abdomen) (61/110), VHL-gene mutation analysis (40/110), and collection of all available clinical, imaging, operative and autopsy data from the hospitals involved. All patients were followed-up with a median of 14 years (excluding 14 operative deaths), and no patient was lost to follow-up. Altogether 49 patients died during the follow-up.  In the 14 VHL patients (13%), HB(s) of the CNS were detected at a median age of 33 years, retinal HB(s) at 39 years, and renal cell carcinoma (RCC) at 43 years. The frequency of VHL in patients operated on for HB(s) was 29% before the age of 25 years, 19% between 25 and 45 years, and only 2% after 45 years. HB patients not meeting the VHL criteria had internal organ cysts in 14%. One non-VHL patient (4%) had two adjacent HBs in the same cyst wall. The growth rates of non-VHL and VHL-related HBs were similar as indicated by the median time to recurrence and the proliferation indices (MIB-1). Recurrence of the HB in patients whose primary operation was considered radical developed in four of the 10 VHL patients at a median of 19 years, and in nine of the 74 non-VHL patients at a median of 11 years. The median length of life of all VHL and non-VHL patients was 46 and 63 years, respectively. In VHL, RCC and HBs were equal causes of death.
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  • 6
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The prognostic value of subjective histological and morphometric grading was studied in 75 primary ovarian carcinomas. Histological grading methods recommended by Czernobilsky and by Russell and the morphometric method of Baak and co-workers were compared in a two-observer system. The 5-year survival could be correctly predicted in about two-thirds of the patients with all three methods. When mitotic counting (volume corrected mitotic index, M/V-index) was compared with the above grading methods by using a receiver operating characteristic curve) the M/V-index was generally superior in its prognostic power regardless of the sensitivity/specificity level chosen. The morphometric grading method and the grading method based on the M/V index were also shown to be readily reproducible.
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 15 (1989), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Prognosis of ovarian carcinomas: prediction by histoquantitative methodsPrediction of prognosis of ovarian carcinomas by morphometric, histopathological and clinical indices was estimated in 105 tumours. Morphometric parameters included mitotic activity index, volume-corrected mitotic index (M/V index), volume fraction of neoplastic epithelium, nuclear area, nuclear perimeter, shortest and longest nuclear axis and form factor of nucleus. Cox's multivariate regression model showed that the clinical stage was the best predictor of prognosis followed by the M/V index, which expresses the mitotic activity as the number of mitotic figures per square millimeter of neoplastic epithelium in the microscope field. In all tumour subgroups studied the M/V index was the best prognostic factor and for stage I tumours it was the only parameter selected by the Cox's model as a significant and independent prognostic predictor. We conclude that the M/V index can be used as a significant prognostic factor in ovarian carcinomas.
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  • 8
    Electronic Resource
    Electronic Resource
    Three Cambridge Center, Suite 208, Cambridge, MA 02142, USA : Blackwell Scientific Publications Inc.
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Prognostic variables predictive of survival in ovarian carcinoma were studied in 91 patients with stage I–IV disease. Univariate analysis showed that clinical stage (FIGO), presence of ascites, age of patient, histologic type and grade, cellular DNA content, morphometric grade, mitotic activity index, and volume corrected mitotic index (M/V index) were prognostic. Multivariate analysis using a Cox model showed that the stage (best predictor in total material), the M/V index (best predictor in stage I tumors), the DNA content (best predictor in advanced stages), and ascites were independently prognostic. Morphometry and/or DNA cytometry should be standard in the histo-pathological evaluation of ovarian carcinomas.
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  • 9
    ISSN: 1432-1335
    Keywords: Transitional cell ; Bladder tumour ; Nuclear image analysis ; Mitotic index ; WHO grade ; Papillary status ; Clinical stage ; Progression ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A retrospective histological analysis has been carried out on 537 cases of transitional-cell bladder carcinoma, followed-up over a period of 9 years. In the first part of the study WHO grade 2 tumours were analysed and a number of independent factors predictive for survival identified. In a multivariate analysis the T category and M/V index (number of mitotic figures/mm2 neoplastic epithelium) were the most important prognostic factors. In a subsequent analysis of the whole series of 537 cases, overall the M/V index was not as important in predicting survival as the stage of the tumour. However, in superficial tumours (Ta−T1) subsequent analysis showed that the M/V index alone could be used to predict survival.
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