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  • 1
    ISSN: 1432-1076
    Keywords: Key words Sacral dysgenesis ; Anal stenosis ; Currarino syndrome ; Chromosome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Most cases of sacral dysgenesis are considered to be sporadic events. We present two families in whom the presence of associated clinical features prompted specific investigation of chromosome 7, leading to the identification of an underlying chromosome 7q deletion causing sacral dysgenesis. All affected individuals had microcephaly and developmental delay. Detailed cytogenetic studies confirmed that all three affected individuals had a deletion of chromosome 7q associated with their sacral dysgenesis, developmental delay and related problems. The three affected patients were studied clinically, radiologically and cytogenetically. Eleven unaffected individuals from the two families were also investigated by genetic studies, specifically evaluating chromosome 7. Conclusion It is important that detailed family history, evaluation of associated malformations and the overall clinical picture be considered in identifying the underlying diagnosis in cases of anal stenosis/sacral agenesis. The cases we present demonstrate the value of detailed chromosome studies in such situations.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 20 (1991), S. 117-119 
    ISSN: 1432-2161
    Keywords: Skeletal dysplasia ; Congenital defects ; Autosomal recessive inheritance ; Osteosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A neonate is described with a lethal sclerosing bone dysplasia associated with prenatal fractures and craniofacial abnormalities including microcephaly, exophthalmos, hypoplastic nose and mid-face, small jaw and nodular hyperplasia of the gums. Parental consanguinity suggests that an autosomal recessive mutation is the likely aetiology.
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  • 3
    ISSN: 0992-7689
    Keywords: Ionosphere (auroral ionosphere; ionosphere-atmosphere interactions) ; Meteorology and atmospheric dynamics (turbulence)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Strong wind shears may result in dynamic instability, often characterised by the Richardson number lying between zero and 0.25. The extent to which electric-field driven ion flow may induce such neutral wind shears is examined. Further, it is proposed that, in the ionosphere, it is possible for electric fields to drive ion winds such that the collisionally induced neutral air response may be comparable to viscous damping of neutral motion. We shall present an analogy to the Reynolds Number Re to quantify this effect. In the same way that Re may be used to evaluate the likelihood of a flow being turbulent, the analagous metric may also indicate where in the atmosphere plasma dynamics may be strong enough to destabilise the neutral dynamics.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Annales geophysicae 16 (1998), S. 1607-1618 
    ISSN: 0992-7689
    Keywords: Meteorology and atmospheric dynamics (middle atmosphere dynamics; turbulence; waves and tides)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The spring of 1997 has represented a stable period of operation for the joint University of Tromsø/University of Saskatchewan MF radar, being between refurbishment and upgrades. We examine the horizontal winds from the February to June inclusive and also include estimates of energy dissipation rates derived from signal fading times and presented as upper limits on the turbulent energy dissipation rate, ɛ. Here we address the periodicity in the dynamics of the upper mesosphere for time scales from hours to one month. Thus, we are able to examine the changes in the spectral signature of the mesospheric dynamics during the transition from winter to summer states.
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  • 5
    ISSN: 1615-6110
    Keywords: Fabaceae ; Arachis ; Arachis hypogaea ; Seed storage proteins ; systematics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 55 accessions of wild peanuts (Arachis spp.) introduced from South America were analyzed for seed storage protein composition using SDS-PAGE electrophoresis. The objectives of the study were to evaluate variability within sect.Arachis and to classify taxa based on protein composition. 25 different band positions were resolved. Individual accessions had 11 to 18 bands which included the conarachin region (MW 〉 50 kD), two to five bands in the acidic arachin region (MW 38–49.9 kD), three to seven in the intermediate MW region (23 to 37.9 kD), two to five bands in the basic arachin region (18–22.9 kD), and one to three bands in the low MW protein region (14–17.9 kD). These data were utilized in a principal coordinate analysis based on the matrix of genetic distances between all pairs of the 55 accessions. Several groups of accessions conformed to expected species classification includingA. batizocoi, A. stenosperma, andA. monticola; whileA. duranensis, A. cardenasii, A. helodes, andA. correntina did not form good groups. The study showed that great diversity exists for protein profiles and seed storage proteins have potential for aiding species classification and for serving as markers for interspecific hybridization studies.
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  • 6
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of the non-steroidal anti-inflammatory drug, ibuprofen, on the progression of periodontal disease was studied in 22 beagle dogs over a 13-month period. Standardized radiographs were used to measure the rate of bone loss. Following a 6-month pretreatment baseline period. 6 dogs were treated daily with 4 mg/kg ibuprofen, 5 dogs were treated with 4 mg/kg ibuprofen in a sustained release preparation, 5 dogs were treated with 0.4 mg/kg ibuprofen and 6 untreated dogs served as controls. In the untreated control dogs the rate of bone loss in the treatment period did not change significantly from baseline, although the rate was increased. In both the 4.0 mg/kg and sustained release 4.0 mg/kg ibuprofen-treated dogs the rate of bone loss in the treatment period was significantly less than the pretreatment period rate. In the 0.4 mg/kg ibuprofen-treated dogs the rate of bone loss, although reduced, was not significantly less than the pretreatment rate. When the rate of bone loss in the control dogs was compared with the rate of bone loss in the ibuprofen-treated dogs, all three ibuprofen-treated groups of dogs had significantly less bone loss than the control dogs. The untreated control dogs lost 10 teeth during the treatment period, whereas the 4.0 mg/kg and 0.4 mg/kg ibuprofen-treated dogs lost 6 teeth and the sustained release 4.0 mg/kg ibuprofen-treated dogs lost 2 teeth during the treatment period. The data indicate that a propionic acid derivative, the non-steroidal anti-inflammatory drug, ibuprofen, can significantly inhibit alveolar bone loss in beagles. Sustained release ibuprofen. which gave consistently greater blood levels over 24 h, was overall more effective.
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  • 7
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of the non-steroidal anti-inflammatory drug flurbiprofen, topically applied, on the progression of periodontal disease was studied in 12 beagle dogs over a 13-month period. Standardized radiographs were used to measure the rate of bone loss. Following a 6-month pretreatment baseline period, 6 dogs were treated daily with 0.3 mg flurbiprofen gently applied to the gingival margin in 1 ml of gel vehicle. Six untreated dogs served as controls. In the untreated control dogs the rate of bone loss in the treatment period did not change significantly from baseline, although the rate was elevated by 38%. In contrast, the rate of bone loss significantly decreased by 71% from baseline in the flurbiprofen-treated dogs. The untreated control dogs lost 10 teeth during the treatment period whereas the topical flurbiprofen-treated dogs lost only 1 tooth. The data indicate that topical application of flurbiprofen in a gel vehicle significantly inhibits alveolar bone loss in beagles over a 7-month treatment period. The data also indicate that topical flurbiprofen is associated with the loss of considerably less teeth than in untreated control dogs over the 7-month treatment period.
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  • 8
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of the nonsteroidal anti-inflammatory drug flurbiprofen has been studied in the ligature-induced and spontaneous periodontitis model in the rhesus monkey, Macaca mulatta. Twenty-four adult monkeys with incipient periodontitis were divided into three disease-matched groups. Two groups received flurbiprofen at dosages of either 0.27 mg/kg/d or 7.1 mg/kg/d delivered systemically via osmotic minipump. A split-mouth approach was used, placing ligatures on one side and monitoring the progression of periodontitis at regular intervals for 6 months. Clinical measurements included standardized radiographs, Ramfjord attachment level determinations and assessments of redness, edema and bleeding on probing. There was a statistically significant inhibition of attachment loss (p 〈 0.05), gingival redness (p 〈 0.05) and bleeding on probing (p 〈 0.05) in ligatureinduced and spontaneous periodontitis in the flurbiprofen-treated animals at 6 months. Eight of 8 ligated control monkeys lost significant attachment (mean loss of 1.06 mm/site). Only 3 of 15 flurbiprofen-treated ligated monkeys lost any significant attachment, with an overall mean loss of 0.34 mm/site, which was significantly less than the control loss of 1.06 mm/site at p = 4.46 times 10-3. The odds of a control ligated monkey undergoing significant attachment loss in 6 months are elevated 29.3-fold, as compared to the flurbiprofen-treated, cohort monkey group. Flurbiprofen treatment also significantly inhibited spontaneous attachment loss for 6 months as compared to control monkeys, at p 〈 0.05. These data provide further evidence for the central role of cyclooxygenase products in the progression of periodontal disease. The ability of flurbiprofen to inhibit periodontal attachment loss, even in the presence of gross plaque accumulation, has significant implications for the potential use of flurbiprofen as an adjunctive periodontal therapeutic modality.
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 307 (1984), S. 352-354 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Komatiites have attracted widespread interest among earth scientists3 because of their unusual geochemistry and mineralogy, and because they are predominantly confined to the Archaean. The Barberton Greenstone Belt contains, in the Onverwacht Group at the base of the Swaziland Supergroup, one of ...
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 300 (1982), S. 52-53 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The direct dating of sulphides with the Rb-Sr technique was attempted by Reesman and Hurley2. The results showed promise, but the approach was never pursued. More recently, Luck and Allegre3 have shown that some deposits may be datable with the Re-Os method. Most promising is the pioneering work on ...
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