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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    ISSN: 0304-4165
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Animal Behaviour 37 (1989), S. 429-443 
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: IS481v1 and IS481v2 are two copies of a Bordetella pertussis insertion sequence element. We have shown that IS481V1 is located within 3kbp of the start of the adenylate cyclase gene whilst IS481v2 is immediately adjacent to the end of the agglutinogen 2 gene and provides the stop codon for that gene. In addition, IS481v1 and IS481v2 were present at these two specific sites in nine strains of B. pertussis, including two Phase IV strains which expressed neither adenylate cyclase nor agglutinogen 2 and three Phase I strains which did not express agglutinogen 2. The loss of expression in these strains is not the result of DNA rearrangements at the sites of IS481 v1 or IS481v2.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two patients are described whose clinical features are interpreted as resulting from simple deletion of, respectively, bands p12 and q242 of chromosome 8.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1238
    Keywords: Key words Fluid resuscitation ; Haemodynamic monitoring ; Stroke distance ; Doppler ultrasound ; Hypovolaemic shock ; Severe sepsis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: To assess the feasibility of constructing left ventricular response curves non-invasively during the fluid resuscitation of critically ill patients in the emergency department (ED) using a portable suprasternal Doppler ultrasound (PSSDU) device.¶Design: Prospective case series.¶Setting: Emergency department, Catholic University of Leuven, Belgium. Patients: Shocked patients in the ED were diagnosed by predefined criteria. Only those thought to require standardised intravenous colloid challenges were observed i. e., sequential boluses of 3.5 ml/kg/10 min titrated against changes in stroke distance (Doppler surrogate for left ventricular stroke volume).¶Results: A total of 50 shocked patients were studied. Stroke distance was measurable in 45 patients. 35 patients were fluid responders in terms of stroke distance. Group mean stroke distance increased during resuscitation (8.6 ± 4.1 cm to 19.5 ± 4.6 cm, P 〈 0.001) and then reached a plateau value (19.6 ± 4.6 cm, P = 0.488). No response to fluid was seen in nine patients of which eight had severe sepsis. Alternative therapeutic approaches increased stroke distance for all of these patients. Evidence for right ventricular dysfunction was found as a cause for fluid non-response in the majority of patients with sepsis.¶Conclusions: Previous experimental work has shown that changes in central blood flow can be derived using the PSSDU device. This clinical feasibility study suggests that the PSSDU can help tailor haemodynamic therapy for an individual patient and give an early indication of treatment failure in the ED.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 7 (1997), S. 161-172 
    ISSN: 1432-1084
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. This article outlines the ability of imaging techniques to stage intrathoracic non-small-cell lung cancer, particularly the extent of primary tumour (T stage), and the presence of nodal metastases (N stage). The detection of hilar and mediastinal lymph-node metastases by CT is covered initially, followed by an appraisal of MRI and radionuclide imaging techniques. Finally, the evaluation of mediastinal and chest-wall invasion by CT and MRI is described, and note is made of developing applications of ultrasound and endosonography. Computed tomography remains the standard technique, but its limitations are discussed, as is the value of other complementary imaging techniques.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-2965
    Keywords: Key words:Body composition – Bone density – Densitometry – Femur – Spine – Total body
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: We assessed a new dual-energy bone densitometer, the PRODIGY, that uses a narrow-angle fan-beam (4.5°) oriented parallel to the longitudinal axis of the body (i.e., perpendicular to the usual orientation). High-resolution scans across the body can be stepped at 17 mm intervals. The energy-sensitive array detector uses cadmium zinc telluride, which allowed rapid photon counting. Spine and femur scans required 30 s, and total-body scans required 4–5 min; the dose was only 3.7 mrem and 0.04 mrem respectively, or about 5 to 10 times lower than conventional fan-beam densitometry. We found only a small influence of soft-tissue thickness on bone mineral density (BMD) results. There was also a small ( ± 1%) influence of height above the tabletop on BMD results. A software correction for object height allowed a first-order correction for the large magnification effects of position on bone mineral content (BMC) and area. Consequently, the results for BMC and area, as well as BMD, with PRODIGY corresponded closely to those obtained using the predecessor DPX densitometer, both in vitro and in vivo; there was a generally high correlation (r= 0.98–0.99) for BMD values. Spine and femur values for BMC, area and BMD averaged within 0.5% in vivo (n= 122), as did total-body BMC and BMD (n= 46). PRODIGY values for total-body lean tissue and fat also corresponded within 1% to DPX values. Regional and total-body BMD were measured with 0.5% precision in vitro and 1% precision in vivo. The new PRODIGY densitometer appears to combine the low dose and high accuracy of pencil-beam densitometry with the speed of fan-beam densitometers.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1433-7339
    Keywords: Key words Xerostomia ; Mouth pain ; Cancer ; Intensity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  An 11-item face-to-face survey was conducted in 99 consecutive patients with advanced cancer to determine the prevalence, intensity, reporting and treatment, presumed cause(s), and importance of mouth pain and dryness. Sixteen of the 99 patients (16%) reported experiencing mouth pain at a mean intensity corresponding to 5.5±SD 2.21 on a 0 (no pain) to 10 (worst possible pain) numerical scale, and 88 (88%) patients reported dry mouth at a mean intensity corresponding to 6.2±SD 2.21. Nine (56%) of the 16 patients with mouth pain and 39 (44%) of the 88 patients with mouth dryness reported these symptoms to their attending physician(s). Sixty-nine percent (27/39) of patients who reported having a dry mouth were advised by their physician(s) to pursue one or more treatments. The most common treatments recommended (and frequencies) were drinking water/taking sips of fluid (13), gargling with bicarbonate mouthwash (4), using an artificial saliva spray (4), and using an oral fungal suspension for thrush (4). The most common findings on oral examination included: possible thrush (53 patients), upper and lower dentures (33 patients), and multiple dental restorations (23 patients). The causes most frequently assumed to be responsible were ill-fitting dentures for mouth pain, and medications and possible oral fungal infections for mouth dryness. The mean values given for the importance of the symptoms of mouth pain and dryness relative to other symptoms or problems experienced by the patients were 4.4±SD 1.84 and 3.6±SD 1.67, respectively, on a Likert scale ranging from 1 (not important) to 7 (great importance). Mouth dryness was more frequently reported than mouth pain. The mean rating for the intensity of mouth pain was higher than that for mouth dryness, although both were of moderate importance to patients relative to other symptoms or problems experienced at the time. Patients tended to underreport mouth pain and dryness, and physicians tended to address such complaints inadequately.
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Experimental Cell Research 3 (1952), S. 65-78 
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das LDH-Isoenzymmuster von 40 menschlichen Tonsillen wurde elektrophoretiseh untersucht. Im Durchschnitt ergibt sich bei den Tonsillen eine etwa gleichstarke Beteiligung des aeroben wie anaeroben Energiestoffwechsels. Eine geschlechtliche Differenzierung war nicht zu erkennen. Mit zunehniendem Alter tritt im paratonsillaren Gewebe and im Kryptenepithel eine leichte Verschiebung zugunsten des anaeroben Stoffwechsels ein In Fallen chronisch rezidivierender Tonsillitis mit Fokalerkrankung war der aerobe Charakter des Energiestoffwechsels besonders im paratonsillaren Gewebe deutlich erhöht, bei Paratonsillitiden deutlich vermindert, ebenso im Kryptenepithel letzterer. Wesentliche Abweichungen von der Norm wurden bei einem Patienten mit einem Morbus Langdon-Down gefunden.
    Notes: Summary The distribution of the LDH isoenzymes of 40 human tonsils has been investigated electrophoretically. The aerobic and anaerobic metabolism was observed without any sex predominance. With the advance of age the paratonsil tissue and the epithelial crypts showed a small displacement towards the anaerobic metabolism. In cases of chronic relapsing tonsillitis with vocal disease the aerobic character especially in the paratonsil tissue was distinctly increased, and in paratonsillitiden and their epithelial crypts were distinctly decreased. Abnormal results were obtained in one patient who suffered from Langdon-Down's disease.
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