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  • 1
    Keywords: evaluation ; Germany ; LUNG ; EMPHYSEMA ; VENTILATION ; DISEASE ; NEW-YORK ; computed tomography ; PATIENT ; NITRIC-OXIDE ; PATTERNS ; tomography ; PRESSURE ; COMPUTED-TOMOGRAPHY ; ATTENUATION ; CINE-CT ; DENSITOMETRY ; FUNCTION TESTS ; OBSTRUCTIVE PULMONARY-DISEASE ; QUANTITATIVE CT ; THIN-SECTION CT ; X-ray computed tomography,lung,densitometry,comparative studies,ventilation,airways dimensions
    Abstract: The aim of this study was to improve the understanding of interdependencies of dynamic changes in central airway dimensions, lung area and lung density on HRCT. The HRCT scans of 156 patients obtained at full inspiratory and expiratory position were evaluated retrospectively. Patients were divided into four groups according to lung function tests: normal subjects (n=47); obstructive (n=74); restrictive (n=19); or mixed ventilatory impairment (n=16). Mean lung density (MLD) was correlated with cross-sectional area of the lung (CSA(L)), cross-sectional area of the trachea (CSA(T)) and diameter of main-stem bronchi (D-B). The CSA(L) was correlated with CSA(T) and D-B. MLD correlated with CSA(L) in normal subjects (r=-0.66, p〈0.0001) and patients with obstructive (r=-0.62, p〈0.0001), restrictive (r=-0.83, p〈0.0001) and mixed ventilatory impairment (r=-0.86, p〈0.0001). The MLD correlated with CSA(T) in the control group (r=-0.50, p〈0.0001) and in patients with obstructive lung impairment (r-0.27, p〈0.05). In patients with normal lung function a correlation between MLD and D-B was found (r=-0.52, p〈0.0001). CSA(L) and CSA(T) correlated in the control group (r=0.67, p〈0.0001) and in patients with obstructive lung disease (r=0.51, p〈0.0001). The CSA(L) and D-B correlated in the control group (r=0.42, p〈0.0001) and in patients with obstructive lung disease (r=0.24, p〈0.05). Correlations for patients with restrictive and mixed lung disease were constantly lower. Dependencies between central and peripheral airway dimensions and lung parenchyma are demonstrated by HRCT. Best correlations are observed in normal subjects and patients with obstructive lung disease. Based on these findings we postulate that the dependencies are the result of air-flow and pressure patterns
    Type of Publication: Journal article published
    PubMed ID: 12811503
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  • 2
    ISSN: 1432-1084
    Keywords: Key words: CT – High-resolution CT – Comparative studies – Lung – Lung function – Ventilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. This study was undertaken to determine prevalence, extent, and severity of focal airtrapping at expiratory high-resolution CT, and to compare focal airtrapping with age, gender, pulmonary function tests, and blood gas analysis. Two-hundred seventeen patients with and without pulmonary disease underwent paired inspiratory/expiratory high-resolution CT. Six scan pairs with corresponding scan levels were visually assessed for focal – not diffuse – airtrapping using a four-point scale. Pulmonary function tests and blood gas analysis were available for correlation in all patients (mean interval 5 days). Focal airtrapping with lower lung predominance was observed in 80 % of patients. Twenty-six of 26 patients with restrictive lung function impairment exhibited focal airtrapping (mean score 2.4), whereas only 72 of 98 (74 %) patients with obstruction did (mean score 1.5; p 〈 0.05). Fifty-eight of 70 (83 %) patients with normal lung function (mean score 1.8) and 19 of 23 (83 %) patients with mixed impairment (mean score 1.8) had focal airtrapping. Focal airtrapping showed negative correlations with static lung volumes (–0.27 to –0.37; p 〈 0.001) in all patients and moderate positive correlations with dynamic parameters (0.3–0.4; p 〈 0.001) in patients with obstruction. No significant correlations were found with age, gender, and blood gas analysis. Visual assessment of focal – not diffuse – airtrapping at expiratory high-resolution CT does not correlate with physiological evidence of obstruction as derived from pulmonary function tests since the perception of focal airtrapping requires an adequate expiratory increase in lung density.
    Type of Medium: Electronic Resource
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