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  • 1
    Call number: SF77:110/2
    Type of Medium: Book
    Pages: 212 p. : , ill. ; , 27 cm.
    ISBN: 0-8493-4390-9
    Language: English
    Location: DKFZ
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  • 2
    Online Resource
    Online Resource
    Baton Rouge : : CRC Press LLC,
    Description / Table of Contents: Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choice of animal species and strains in different research disciplines. Efficient and humane experimental work with animals, in which subjects experience no avoidable pain and mental distress, requires skillful and conscientious staff. To this end, scientists apply the three R's: replacing experiments on live animals with alternative methods, reducing the number of animals necessary to obtain valid results within experiments, and refining techniques to minimize the discomfort experienced by the animal participants.
    Type of Medium: Online Resource
    Pages: 1 online resource (469 pages)
    Edition: 3rd ed.
    ISBN: 9781420084580
    Language: English
    Note: Front Cover -- Contents -- Preface -- Editors -- Contributors -- Chapter 1 - Animal Models -- Chapter 2 - Animal Models for Human Behavior -- Chapter 3 - Animal Models for Psychological Disorders -- Chapter 4 - Animal Models in Neuroscience -- Chapter 5 - Induced Animal Models of Parkinson's Disease -- Chapter 6 - Animal Models in Aging and Alzheimer's Disease -- Chapter 7 - Animal Models in Pain Research -- Chapter 8 - Animal Models in Pharmacology and Toxicology -- Chapter 9 - Animal Models for Otolaryngological Disorders -- Chapter 10 - Animal Models of Lung Physiology during Anesthesia -- Chapter 11 - Animal Models of Female Reproduction and Fetal Growth and Development -- Chapter 12 - Animal Models in Vaccinology -- Chapter 13 - Animal Models in AIDS Research -- Chapter 14 - Animal Models for the Study of Helicobacter Infection -- Chapter 15 - Animal Models in Mycology -- Chapter 16 - Animal Models in Biodefense Research -- Chapter 17 - Animal Models in Oral Health Sciences -- Chapter 18 - Animal Models of Hearing Loss and Tinnitus -- Back Cover.
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  • 3
    Online Resource
    Online Resource
    Baton Rouge : : Taylor & Francis Group,
    Description / Table of Contents: Praise for the previous volumes: "The strength of these volumes is in their ability to cover a broad range of topics, yet in such detail. This set would be an asset to the graduate student and researcher needing an excellent reference manual."-Sandra L. Jex, Animal Lab News.
    Type of Medium: Online Resource
    Pages: 1 online resource (334 pages)
    Edition: 3rd ed.
    ISBN: 9781466555136
    Language: English
    Note: Front Cover -- Contents -- Preface -- About the Editors -- Contributors -- Chapter 1: Animal Models of Spinal Cord Injury -- Chapter 2: Animal Models for Tropical Parasitic Diseases -- Chapter 3: Animal Models of Cardiovascular Disease -- Chapter 4: Animal Models of Sudden Infant Death Syndrome -- Chapter 5: Animal Models of Developmental Processes and Developmental Disorders for Social Genomics and Beyond -- Chapter 6: Animal Models of Metabolic and Inflammatory Diseases -- Chapter 7: Animal Models for Eye Diseases -- Chapter 8: Animal Models of Human Cancer -- Chapter 9: Reduction and Refinement Applied to Animal Models -- Back Cover.
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  • 4
    Online Resource
    Online Resource
    Baton Rouge : : Taylor & Francis Group,
    Description / Table of Contents: Laboratory animal testing provides most of our current knowledge of human physiology, microbiology, immunology, pharmacology, and pathology. From studies of genetics in fruit flies to studies of cellular processes in genetically modified mice to recent dramatic developments in genetics, translational research, and personalized medicines, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences and all rely on access to high-quality laboratory animals as models for humans. Rooted in the principle that good science can only be performed in environments that promote good animal welfare, this third edition of the bestselling Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices emphasizes the importance of implementing the three R's: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort, and integrates these humane principles into almost every chapter. See what's new in the Third Edition: New chapters: Applications of Radio-Telemetry in Small Laboratory Animals, Generation and analysis of genetically modified mice, and Physiological, Hematological, and Clinical Chemistry Parameters Additional mateiral on the international harmonization of practices and on the continued implementation of the refinement, reduction, and replacement of animal usage in laboratories Sixteen page color insert Relevant to virtually all areas of laboratory science and forming the cornerstone of laboratory animal science, each individual chapter focuses on an important subdiscipline of laboratory animal science including humane laws and guidelines; non-surgical, surgical, microsurgical, and post-mortem procedures; genetic modification; nutrition, feeding, and
    Description / Table of Contents: environmental factors; experiment design and alternative methods; and analgesia, anesthesia, and euthanasia. Each chapter can be read in series or as a stand alone text. A truly international effort from world renowned contributors, Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices, Third Edition is useful as a textbook in laboratory animal science courses for postgraduate and undergraduate students, as a handbook for scientists who work with animals in their research, and for university veterinarians, regulators, and other specialists in laboratory animal science.
    Type of Medium: Online Resource
    Pages: 1 online resource (758 pages)
    Edition: 3rd ed.
    ISBN: 9781420084566
    Language: English
    Note: Front cover -- Contents -- Preface -- Editors -- Contributors -- Chapter 1. The Contribution of Laboratory Animals to Medical Progress-Past, Present, and Future -- Chapter 2. Ethics of Animal Research -- Chapter 3. An Overview of Global Legislation, Regulation, and Policies -- Chapter 4. Assessment of Animal Care and Use Programs and Facilities -- Chapter 5. Education and Training -- Chapter 6. Laboratory Animal Science and Service Organizations -- Chapter 7. Laboratory Animal Allergies and Zoonoses -- Chapter 8. Laboratory Animal Facilities and Equipment for Conventional, Barrier, and Containment Housing Systems -- Chapter 9. Laboratory Animal Genetics and Genetic Quality Control -- Chapter 10. Health Status and Health Monitoring -- Chapter 11. Nutrient Requirements, Experimental Design, and Feeding Schedules in Animal Experimentation -- Chapter 12. Impact of the Biotic and Abiotic Environment on Animal Experiments -- Chapter 13. Experimental Design and Statistical Analysis -- Chapter 14. Common Nonsurgical Techniques and Procedures -- Chapter 15. Applications of Radiotelemetry in Small Laboratory Animals -- Chapter 16. Immunization for Production of Antibodies -- Chapter 17. Laboratory Animal Analgesia, Anesthesia, and Euthanasia -- Chapter 18. Welfare Assessment and Humane End Points -- Chapter 19. Surgery: Basic Principles and Procedures -- Chapter 20. Microsurgical Procedures in Experimental Research -- Chapter 21. Postmortem Procedures -- Chapter 22. Alternatives: Refinement, Reduction, and Replacement of Animal Uses in the Life Sciences -- Chapter 23. Generation and Analysis of Genetically Modified Mice -- Chapter 24. Physiological, Hematological, and Clinical Chemistry Parameters, Including Conversion Factors -- Index -- Back cover.
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  • 5
    Call number: SF77:110/1
    Type of Medium: Book
    Pages: 435 p. : , ill. ; , 27 cm.
    ISBN: 0-8493-4378-X
    Language: English
    Location: DKFZ
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  • 6
    Call number: SF77:110(3)/1
    Type of Medium: Book
    Pages: xv, 723 p. : , ill.
    Edition: 3rd ed.
    ISBN: 9781420084559 (hardcover : alk. paper)
    Language: English
    Note: v. 1. Essential principles and practices.
    Location: DKFZ
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  • 7
    Book
    Book
    Boca Raton, FL : : Taylor & Francis,
    Call number: SF77:110(3)/2
    Type of Medium: Book
    Pages: xii, 465 p. : , ill. ; , 27 cm.
    ISBN: 9781420084573
    Language: English
    Location: DKFZ
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  • 8
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The murine model of mycotic mastitis was used to study the efficacy of amphotericin B (AmB). Twenty-four BALB/cJ mice at the fifth day of lactation were anesthetized and inoculated through the teat canal (two glands) with 50 μl suspension containing 5.0×107 cfu ml−1Candida albicans blastospores. Mice were randomly divided into two groups: untreated controls and AmB treated. Animals were euthanized 3 and 6 days after infection and treatment (4 mg kg−1 per day intraperitoneally). The fungal burden of the mammary gland was determined by quantitative cultures. The number of C. albicans cells recovered from mammary gland homogenates were significantly lower in the AmB treated animals (both 3 and 6 days post-infection) than in the untreated controls (P〈0.007 and P〈0.003, respectively). The mammary glands of all untreated control animals showed marked neutrophilic infiltration, severe necrosis, and presence of blastospores, hyphae and pseudohyphae. In contrast, 10 of 12 animals treated with AmB showed only a mild neutrophilic infiltration which was restricted to alveoli and excretory ducts. All extra-mammary organs were free of infection in both groups. The results demonstrate that the murine mycotic mastitis model is suitable for investigations of new antifungal compounds. In addition, this model is more lenient than the systemic candidiasis models.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A small animal model of localised candidiasis is needed for the evaluation of new antifungal compounds. Mammary glands of immunocompetent (BALB/cJ) and immunodeficient (SCID and athymic nude) mice were infected with a wild-type of Candida albicans. Some of the animals were treated with amphotericin B (AmB) while others were treated with saline and acted as controls. The histologic changes of infected mammary gland tissues and a number of other organs were evaluated. Complement (C) activation was analysed by immunoelectrophoretic quantification of molecules with C3c epitopes (C3, C3b, iC3b, and C3c) in serum. In all animals the organisms were confined to the mammary glands. Serum C3c levels were significantly higher (P〈0.05) in infected untreated BALB/cJ and SCID mice, which also had severe mammary gland tissue inflammation, compared with control mice treated with AmB (4 mg kg−1 i.p. once daily for 4 days). Both treated and control nude mice showed less tissue inflammation compared to BALB/cJ and SCID mice, and revealed insignificant activation of the complement system. It is concluded that innate immune response is important in the control of candidiasis and that the murine mastitis model is useful for immunopathological studies as well as evaluation of potential antifungal compounds.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Candida albicans strains with a deletion of the mitogen-activated protein kinase CEK1 gene are defective in the yeast to hyphal transition on solid surfaces in vitro. The virulence of a cek1Δ/cek1Δ null mutant strain was compared with its wild-type parent strain (WT) in a novel model of localized candidiasis. The mammary glands of lactating mice (at day 5 postpartum) were infected for 2, 4 and 6 days with 50 μl suspension containing 1×105, 1×106 and 1×107 blastospores before death. Infected and non-infected control glands were evaluated pathologically. All animals infected with cek1Δ/cek1Δ null mutant strains showed no lesions while 65% of animals infected with the WT strain had severe lesions characterized by widespread heterophilic infiltration, necrosis, and abscess formation. As an additional control, animals infected with the disrupted strain complemented with the WT CEK1, on a replicating plasmid, also showed severe pathological changes similar to the WT strain. These results clearly demonstrate that the CEK1 gene codes for a virulence determinant of C. albicans and that the mouse mastitis model is well suited for the discriminative study of the pathogenicity of different C. albicans strains.
    Type of Medium: Electronic Resource
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