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  • 1
    ISSN: 1432-069X
    Keywords: Sézary syndrome ; Monoclonal antibodies ; T lymphocytes ; Langerhans cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using an immunoperoxidase (skin biopsy) and an immunofluorescence (peripheral blood, bone marrow punctate) technique, and monoclonal antibodies raised against peripheral mature lymphocytes, T helper subsets, T suppressor subsets, and Langerhans cells, we found a predominant dermal infiltration with lymphocytes of the suppressor phenotype and a predominant epidermal infiltration with Langerhans cells in a patient with Sézary syndrome (cutaneous T-cell lymphoma, CTCL). Repeated peripheral blood examinations showed an increased percentage of lymphocytes of the helper phenotype. A bone marrow examination revealed a ratio of suppressor/helper subsets of 1:4. The findings in the skin seem to be inconsistent with most of the results of previous studies in patients with CTCL; the significance of these findings is discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einem Gesamtkollektiv von 1431 Speicheldrüsentumoren des Speicheldrüsenregisters (1965–1976) wurde eine Beobachtung registriert, welche als „Carcinom in einem papillären Cystadenolymphom“ klassifiziert wurde. In Parallele zum „Carcinom in einem pleomorphen Adenom“ der WHO-Klassifikation der Speicheldrüsentumoren wird der Begriff „Carcinom in einem Cystadenolymphom“ näher definiert. Zugleich werden auch 6 weitere Beobachtungen des Weltschrifttums zusammengestellt. Die mögliche Rolle von Epithelmetaplasien und der Einfluß einer vorausgegangenen Strahlentherapie auf die Carcinomentstehung in Cystadenolymphomen werden diskutiert. Differentialdiagnostisch müssen folgende andere Tumorformen vom Carcinom in einem Cystadenolymphom abgegrenzt werden: Metastasen eines anderen Primärtumors außerhalb eines Cystadenolymphoms mit Metastasierung in ein Cystadenolymphom; maligne lymphoepitheliale Läsionen (vorwiegend maligne Lymphome bei einer vorbestehenden Immun-Sialadenitis vom Typus einer myoepithelialen Sialadenitis, seltener Carcinome) und Lymphoepitheliome.
    Notes: Summary Within a collective of 1431 salivary gland tumors of the salivary gland register (1965–1976) an observation has been done, which has been classified as a “carcinoma in a papillary cystadenolymphoma”. Corresponding to the “carcinoma in a pleomorphous adenoma” of the WHO-classification of salivary gland tumors the terminus “carcinoma in a cystadenolymphoma” is further defined. 6 additional cases from the literature are reviewed. The possible role of epithelial metaplasia and of a preceding radiation in the development of carcinomas in cystadenolymphomas are discussed. The following other tumors have to be differentiated from a carcinoma in a cystadenolymphoma: Metastases of other tumors beyond a cystadenolymphoma; malignant lymphoepithelial lesions (predominantly malignant lymphomas in a preexisting immune-sialadenitis of the myoepithelial sialadenitis type; rare carcinomas), and lymphoepitheliomas.
    Type of Medium: Electronic Resource
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