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  • 1
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    Philadelphia : Lippincott Williams & Wilkins
    Call number: D0200:109 ; ATV-ONK:109(6)a ; D0900:15
    Keywords: Neoplasms
    Pages: lxxii, 3235, 164 p. : ill.
    Edition: 6th ed.
    ISBN: 0-7817-2229-2
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    D0200:109 departmental collection or stack – please contact the library
    ATV-ONK:109(6)a departmental collection or stack – please contact the library
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  • 2
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    Philadelphia : Lippincott Williams & Wilkins
    Call number: ATV-ONK:109(7)
    Keywords: Neoplasms
    Pages: lxxv, 2898, I 158 p. : ill. + 1 CD-ROM
    Edition: 7th ed.
    ISBN: 0-7817-4450-4
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  • 3
    Call number: F065:14
    Keywords: Neoplasms
    Notes: Prev. ed. has title: Cancer : principles & practice of oncology.
    Pages: xxiv p., p.1487-3039, I-112 p. : ill.
    Edition: 8th ed.
    ISBN: 0-7817-7207-9
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  • 4
    Call number: F065:13
    Keywords: Neoplasms
    Notes: Prev. ed. has title: Cancer : principles & practice of oncology.
    Pages: lxxii, 1485, I-112 p. : ill.
    Edition: 8th ed.
    ISBN: 0-7817-7207-5
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  • 5
    Call number: QZ200:527(11)
    Keywords: Neoplasms
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php)
    Pages: xli, 2390 p. : ill.
    Edition: 11th ed.
    ISBN: 9781496394637
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  • 6
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    Philadelphia : Lippincott Williams & Wilkins
    Call number: E050:21
    Keywords: Neoplasms
    Notes: Prev. ed. has title: Cancer : principles & practice of oncology.
    Pages: xlv, 2638 p. : ill.
    Edition: 9th ed.
    ISBN: 9781451118131
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  • 7
    ISSN: 1573-7217
    Keywords: angiogenesis ; age ; breast cancer ; immunohistochemistry ; neovascularization ; prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The search for prognostic markers is important both to identify those patients with occult metastases and also to spare chemotherapy in those patients whose tumors have not developed the capacity for distant spread. Angiogenesis, the formation of new blood vessels, is necessary for breast cancer growth and metastasis. Good correlation has been demonstrated between intratumoral vascularization and outcome in patients with breast cancer. Intratumoral vascularization in human breast cancer can be measured by using standard immunohistochemical methods. Strict guidelines for scoring need to be followed. Although attempts are being made to automate the reading, visual scoring remains superior. We studied a population of women with small node-negative breast cancer who received no adjuvant therapy and have a median follow-up of 15 years. We have found intratumoral vascularization, as measured by microvessel count, to be an independent prognostic factor for disease-free survival. Low microvessel count identifies a group of patients with a 20 year disease free survival of 93%. The proportion of women with low microvessel count decreases with increase in tumor size and increases with patient age. But even in mammographically detected nonpalpable breast cancer, that is, the smallest breast cancer we currently detect, the majority already have high microvessel count. Intratumoral vascularization appears to be an early event that is necessary but not sufficient for metastatic progression. Microvessel count seems to be an excellent marker to identify patients with good prognosis because those with low microvessel count have a 93% disease-free survival irrespective of size, grade, or estrogen receptor status, but is less good at predicting those at high risk since the 20-year disease-free survival is still 67-70% in those with high microvessel count. Thus, the higher risk group needs to be further stratified using additional prognostic factors.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 121 (1984), S. 275-283 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Hematopoietic stem cells with high proliferative capacity can be assayed when stromal bone marrow cultures are overlaid with limiting dilutions of marrow samples. This leads to hematopoietic growth after 4 weeks in a fraction of cultures, consistent with expectations based on Poisson statistics. It will be shown that monoclonal cultures are obtained that last from 2 to 15 weeks and that can generate up to several million mature granulocytes. The originating clone-forming cell is named adherent stem cell (ASC) because of its adherence to plastic or stromal surfaces. The ASC is comparable to the CFU-S in frequency, proliferative capacity and in its ability to give rise to CFU-S. As an unexpected additional finding we report that a mode of “clonal succession” was apparent in cultures which expressed more than one clone.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 112 (1982), S. 345-352 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Residual radiation injury was demonstrated in long-term primary cultures of mouse bone marrow. Control cultures underwent three phases of hematopoietic activity as distinguished by initial establishment, steady high (plateau) production of granulocytes, and gradual decline. Irradiation with 50, 300, or 550 rads, given at the end of the initial phase, did not prevent any culture flasks from entering the plateau phase. However, actual production levels and the time they were maintained varied inversely with the radiation dose so that the accumulated postradiation cell production corresponded to an exponential dose-response relationship at any time after treatment. The accumulated cell productions were found to be similar in all groups when expressed by the number of stem cell doublings necessary to produce them. The findings cannot be explained by reproductive cell death and are consistent with the notion of a limited division capacity in hematopoietic stem cells.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature medicine 1 (1995), S. 400-402 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] These are extraordinary times in medicine. There is both a revolution in the biology relevant to medicine and a revolution in the delivery of health care. We must translate laboratory discoveries into clinical practice, and we must do so in an increasingly cost-conscious environment. Faced with ...
    Type of Medium: Electronic Resource
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